DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment neo and nompA

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_524831.2	Gene:	nompA / 45587	FlyBaseID:	FBgn0016047	Length:	1557	Species:	Drosophila melanogaster

Alignment Length:	586	Identity:	139/586 - (23%)
Similarity:	213/586 - (36%)	Gaps:	180/586 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 VKRTVSVASRRECFELCLGENDFTCRSANYDRTSGACELSELDRLTLAGSQAFQVNDGSDYLENH 285
            |:|.:.|.|..:|...|:...||.|||.|| |.|.|....:.||                   :.
  Fly   931 VRRALIVPSLIQCERECIESRDFVCRSFNY-RDSAASGYEDRDR-------------------DR 975

  Fly   286 CVDEPNKLCEFKRLPGRILKTVDSVYQEVSSIDECRELCLNSP--YRCHSYDYNDTGDMVCRLSH 348
            ..|.||  ||        |...||           |||.::.|  :...:||:
  Fly   976 DRDSPN--CE--------LSDRDS-----------RELDIHDPGTFDASNYDF------------ 1007

  Fly   349 HSRATLADVQEPFLEVPEASTYELT------SCYNVTIECGGGDMLARIRTSKLFNGKVYAKGSP 407
                                 ||.:      .|.:||..|....|...|||.:.|.|::|..|..
  Fly  1008 ---------------------YERSIGRSDGECMDVTQTCNEEGMEFTIRTPEGFLGRIYTYGFY 1051

  Fly   408 KSC-------SVDVKSALDFELRMN----YHDLECNVRQSTAGRY----VNDIIIQHHDMIVTSS 457
            ..|       :|:|       ||::    |.|  |..:     ||    .|.:::|..|.:.||.
  Fly  1052 DRCFFRGNGGTVNV-------LRLSGPQGYPD--CGTQ-----RYGDTLTNIVVVQFSDNVQTSR 1102

  Fly   458 DLGLALACQYDLTNKSV--------SNGVDLDVRGDIMPA---LSEEVIVESPNVIMRITSRDGS 511
            |....|.|.:....::|        .:|..:.:  :.:||   ||.:|         |::.....
  Fly  1103 DKRYNLTCIFRGPGEAVVSSGYIGAGSGSPIPI--EYLPAENTLSSKV---------RLSILYQG 1156

  Fly   512 DMMRSAEVGDPLALKFEIVDEQSPY-EIFIRELVAMDGVDNSEITLIDSNGCPTDHFIMGPIYKG 575
            ....:..|||||..:.|..|..:.. :||...:||.|......|.|||..|||.|.|:...:.|
  Fly  1157 RPTTTIAVGDPLTFRLEAQDGYNHVTDIFATNVVARDPYSGRSIQLIDRFGCPVDPFVFPELDK- 1220

  Fly   576 SVSGKMLLSNFDAFKFPSSEVVQFRALVTPCMPSCEPVQC-----EQEDTSGEFRSLLSYGRKRR 635
            ...|..|.:.|:|||.|.|..:.|.|.|..|...|:|..|     .||.         |:||:||
  Fly  1221 LRDGDTLEARFNAFKIPESNFLVFEATVRSCREGCQPAYCPGPAGRQEP---------SFGRRRR 1276

  Fly   636 SLNTTDDHPRPR------------------RDIDTSKKSAPSDMLLVQSIQITDKFGFKQDKQES 682
            ||||| :.|.|.                  ..::::..||....:.:...|:.:|....::.::.
  Fly  1277 SLNTT-EIPEPEALALEGSSQLEASTLDEVTVVNSTTVSATLGQVPLNETQLGEKTKETEEPEQV 1340

  Fly   683 GDFYDGNETTFTANEEGH---------GFCVNAI---GLITAATIFLLTQLAVIAIWTYCYQRRQ 735
            .:..:..||.....:|.:         ..|:...   |||||..:.::...::..:....|:|..
  Fly  1341 REMIEVFETREEIEKESYPRKLVAPVETVCMTPAEYHGLITAIILLMILLFSITLVAGLGYRRYW 1405

  Fly   736 K 736
            |
  Fly  1406 K 1406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453
		PAN_AP_HGF	211..285	CDD:238532	18/63 (29%)
		PAN_1	294..373	CDD:278453	13/80 (16%)
		ZP	381..615	CDD:214579	71/260 (27%)
nompA	NP_524831.2	PAN_AP_HGF	150..231	CDD:238532
		PAN_AP_HGF	244..>303	CDD:238532
		PAN_AP_HGF	349..424	CDD:238532
		PAN_AP_HGF	914..1011	CDD:238532	34/153 (22%)
		ZP	1025..1264	CDD:214579	72/264 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JEZ
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910