DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neo and nyo

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_651871.2	Gene:	nyo / 43716	FlyBaseID:	FBgn0039852	Length:	805	Species:	Drosophila melanogaster

Alignment Length:	743	Identity:	435/743 - (58%)
Similarity:	548/743 - (73%)	Gaps:	70/743 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 AKETSTEINRTERPVENVETRN--------------SGFDLPAA-SDLSSSLGSEEDSI------ 104
            |.:.::...:|:|||:.|:..|              ||...||: |..:::.||.:..:
  Fly    16 ASDAASAARKTKRPVKPVKQTNPRTNVTPSPPAVASSGSSTPASTSSTTTTEGSGDQEVATVGSA 80

  Fly   105 ----------------------YYDNAPV---DCNPELVGFEIVTGYVFSAPEKLMDSQPGTLML 144
                                  ..|.||.   :|:|:::||||:||||.|||.|::|:.||||||
  Fly    81 ALAGGGELPKPLVTPIEAQPEAKTDKAPALEEECDPDMIGFEIITGYVLSAPSKMLDTLPGTLML 145

  Fly   145 TDCLDTCRKNKTCQSVNYETGLCVLFSAHADQLPGALTKSQFPVFTIYAQKSCLAVKPCSRAWYV 209
            ||||:.|:.|::|.:|||||||||||...||:|||:|::|||||||||||||||.|:|||:||.:
  Fly   146 TDCLEACQSNESCSAVNYETGLCVLFKTTADKLPGSLSRSQFPVFTIYAQKSCLGVRPCSKAWCI 210

  Fly   210 DRVQNYKLKTEVKRTVSVASRRECFELCLGENDFTCRSANYDRTSGACELSELDRLTLAGSQAFQ 274
            ||||.|:|...||.:.:|.|||:|.||||||.:||||||||.|.||.||||::||:||:...:.:
  Fly   211 DRVQGYRLPEHVKSSQTVLSRRDCLELCLGETEFTCRSANYYRHSGLCELSDMDRITLSAGGSVE 275

  Fly   275 VNDGSDYLENHCVDEPNKLCEFKRLPGRILKTVDSVYQEVSSIDECRELCLNSPYRCHSYDYNDT 339
            ..||:|||||:|.:||:|||||||:.|:||||||||||::::|||||:|||||||||||||||||
  Fly   276 PYDGADYLENNCAEEPSKLCEFKRISGKILKTVDSVYQDINTIDECRDLCLNSPYRCHSYDYNDT 340

  Fly   340 GDMVCRLSHHSRATLADVQEPFLEVPEASTYELTSCYNVTIECGGGDMLARIRTSKLFNGKVYAK 404
            |||||||||||||||.||.:|:|:||||:||||::||||:|||..|:|:.:|||||||:||||||
  Fly   341 GDMVCRLSHHSRATLTDVMDPYLDVPEAATYELSACYNVSIECRSGEMITKIRTSKLFDGKVYAK 405

  Fly   405 GSPKSCSVDVKSALDFELRMNYHDLECNVRQSTAGRYVNDIIIQHHDMIVTSSDLGLALACQYDL 469
            |:||||:|:|.::|:|:.||.|:|||||||||..|||:|||:||||||||||||||||::|||||
  Fly   406 GAPKSCAVNVNNSLEFDFRMGYNDLECNVRQSAYGRYMNDIVIQHHDMIVTSSDLGLAVSCQYDL 470

  Fly   470 TNKSVSNGVDLDVRGDIMPALSEEVIVESPNVIMRITSRDGSDMMRSAEVGDPLALKFEIVDEQS 534
            |||:|.|.|||.|.|:|..:||||:.::||||||:|||||||||.|.|||||||||:||||:..|
  Fly   471 TNKTVLNDVDLGVTGEIESSLSEEITIDSPNVIMKITSRDGSDMKRMAEVGDPLALRFEIVEPNS 535

  Fly   535 PYEIFIRELVAMDGVDNSEITLIDSNGCPTDHFIMGPIYKGSVSGKMLLSNFDAFKFPSSEVVQF 599
            |||||:||||||||.|::||||||:||||||.:|||.|.|.:.:.|:|||.||||||||||||||
  Fly   536 PYEIFVRELVAMDGSDSAEITLIDANGCPTDQYIMGTIQKLAQNRKVLLSQFDAFKFPSSEVVQF 600

  Fly   600 RALVTPCMPSCEPVQCEQED-TSGEFRSLLSYGRKRRS-LNTTDD-----HPRPRRDIDTSKKSA 657
            |||||||:|.||||.|:.|| .|||.:||:|||||:|| ||.||.     ..|.|||:      .
  Fly   601 RALVTPCIPRCEPVICDSEDGASGELKSLVSYGRKKRSVLNGTDGAEFLISTRHRRDV------G 659

  Fly   658 PSD--MLLVQSIQITDKFGFKQDKQESGDFYDGN-----ETTFTANEEGHGFCVNAIGLITAATI 715
            |.|  :||:|||||||||||   :.|.|....||     |..:....:....|:|..|||.|..:
  Fly   660 PVDDNILLMQSIQITDKFGF---QPEDGTTTHGNDSGPHEKAYAGVAQDKLTCLNGYGLIMAGAL 721

  Fly   716 FLLTQLAVIAIWTYCYQRRQKLQ-PYQH 742
            |||.||::..||....:|..|.: .|||
  Fly   722 FLLAQLSIFGIWKTVQRRTSKERYLYQH 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453	54/76 (71%)
		PAN_AP_HGF	211..285	CDD:238532	43/73 (59%)
		PAN_1	294..373	CDD:278453	64/78 (82%)
		ZP	381..615	CDD:214579	171/233 (73%)
nyo	NP_651871.2	PAN_1	121..198	CDD:278453	54/76 (71%)
		PAN_AP_HGF	208..286	CDD:238532	45/77 (58%)
		PAN_1	295..374	CDD:278453	64/78 (82%)
		ZP	382..618	CDD:214579	172/235 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469583
Domainoid	1	1.000	78	1.000	Domainoid score	I5679
eggNOG	1	0.900	-	-		E1_28JEZ
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	106	1.000	Inparanoid score	I3502
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28231
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005301
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_115610
Panther	1	1.100	-	-	P	PTHR47327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X161
	10	9.800