DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neo and mey

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_001287622.1	Gene:	mey / 43715	FlyBaseID:	FBgn0039851	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	783	Identity:	418/783 - (53%)
Similarity:	544/783 - (69%)	Gaps:	78/783 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 INLLRHLFLALMLYSAATAKEHLRIRRQAAESVTAAAPNASKVMASEEIKDKTEWPGAKETSTEI 68
            ::::..|.|.|:|...:.|...|..|.......|....||:.:..:          ||.......
  Fly    12 VSMMALLGLMLLLVDTSVAARKLPKRPAVKPLKTFPRNNATPIPPT----------GAGSGVATP 66

  Fly    69 NRTERP----VENVET----------RNSGFDL-----PAASDLSSSLGSEEDSIYYDNAPV--- 111
            |.:|.|    ||..|.          .:||...     |||:..::...::.|.:  |..|:
  Fly    67 NGSELPKPLSVEPAEAIAASPPGSIGDSSGASAAAPVPPAAASAAAVAETKADDL--DPTPMATP 129

  Fly   112 --------DCNPELVGFEIVTGYVFSAPEKLMDSQPGTLMLTDCLDTCRKNKTCQSVNYETGLCV 168
                    ||.|:::|||::||||.|||.|.:::.||||||||||:.|:.|::|.:|||||||||
  Fly   130 SGSSSVDEDCEPDMIGFELITGYVLSAPSKQLETLPGTLMLTDCLEACQANESCSAVNYETGLCV 194

  Fly   169 LFSAHADQLPGALTKSQFPVFTIYAQKSCLAVKPCSRAWYVDRVQNYKLKTEVKRTVSVASRREC 233
            :|.:.||||||:|::||:||||:||||||..|:|||:||.:||||.|:|....|.:.|||:||:|
  Fly   195 MFRSTADQLPGSLSRSQYPVFTVYAQKSCFGVRPCSKAWCIDRVQGYRLPERAKASQSVATRRDC 259

  Fly   234 FELCLGENDFTCRSANYDRTSGACELSELDRLTLAGSQAFQVNDGSDYLENHCVDEPNKLCEFKR 298
            .||||||.:||||||||...||.||||::||:||:........||:|||||:|.:||:|||||||
  Fly   260 IELCLGETEFTCRSANYYAHSGLCELSDMDRITLSDEANIAAYDGADYLENNCAEEPSKLCEFKR 324

  Fly   299 LPGRILKTVDSVYQEVSSIDECRELCLNSPYRCHSYDYNDTGDMVCRLSHHSRATLADVQEPFLE 363
            :.||||||||||:|.|.::||||:|||.:|:||||||||:||::||||||||||||.|:.||:|.
  Fly   325 VAGRILKTVDSVHQNVQTLDECRDLCLTAPFRCHSYDYNETGELVCRLSHHSRATLTDLSEPYLS 389

  Fly   364 VPEASTYELTSCYNVTIECGGGDMLARIRTSKLFNGKVYAKGSPKSCSVDVKSALDFELRMNYHD 428
            :.||:|||.::||||:|:|..|:|:.:|||||||:|||||||:||||:|:|.::|:|:|:|.|:|
  Fly   390 IEEAATYEQSACYNVSIDCRSGEMITKIRTSKLFDGKVYAKGAPKSCAVNVNNSLEFDLKMRYND 454

  Fly   429 LECNVRQSTAGRYVNDIIIQHHDMIVTSSDLGLALACQYDLTNKSVSNGVDLDVRGDIMPALSEE 493
            ||||||||..|||:|||:||||||||||||||||::||||||||:|.|.|||.|.|:|...||||
  Fly   455 LECNVRQSAYGRYMNDIVIQHHDMIVTSSDLGLAVSCQYDLTNKTVVNNVDLGVTGEIESTLSEE 519

  Fly   494 VIVESPNVIMRITSRDGSDMMRSAEVGDPLALKFEIVDEQSPYEIFIRELVAMDGVDNSEITLID 558
            :||:||||||:||:||||||.|.|||||||||:|||||..||||||:||||||||.|::||||||
  Fly   520 IIVDSPNVIMKITARDGSDMKRIAEVGDPLALRFEIVDANSPYEIFVRELVAMDGTDSAEITLID 584

  Fly   559 SNGCPTDHFIMGPIYKGSVSGKMLLSNFDAFKFPSSEVVQFRALVTPCMPSCEPVQCEQEDTSGE 623
            :||||||.:||..:.|.:.:.|:|||.||||||||||:||||||||||:|.||||.|: .|.:||
  Fly   585 ANGCPTDQYIMSAMQKLANNRKVLLSQFDAFKFPSSELVQFRALVTPCIPRCEPVICD-NDENGE 648

  Fly   624 FRSLLSYGRKRRS-LNTTD------DHPRPRRDIDTSKKSAPSDMLLVQSIQITDKFGFKQDKQE 681
            .:|||||||::|| ||.||      ...|.:||: :.:.:...::||||||||||||.|
  Fly   649 LKSLLSYGRRKRSVLNGTDGVELAIKSERQKRDV-SHQAAGDENILLVQSIQITDKFAF------ 706

  Fly   682 SGDFYDGNETTFTANEEGHGF----------------CVNAIGLITAATIFLLTQLAVIAIWTYC 730
                 :|.:....:..|..|.                |:|..|.|.|..:|||.||.|||:|...
  Fly   707 -----NGADAPGGSGSEAGGLDGLAKLQLDLGTKSDTCINGYGFIIAGALFLLLQLTVIAVWDNM 766

  Fly   731 YQR 733
            .:|
  Fly   767 QKR 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453	50/76 (66%)
		PAN_AP_HGF	211..285	CDD:238532	42/73 (58%)
		PAN_1	294..373	CDD:278453	56/78 (72%)
		ZP	381..615	CDD:214579	169/233 (73%)
mey	NP_001287622.1	PAN_1	146..223	CDD:278453	50/76 (66%)
		PAN_AP_HGF	233..311	CDD:238532	44/77 (57%)
		PAN_AP_HGF	319..>380	CDD:238532	46/60 (77%)
		ZP	408..642	CDD:214579	169/233 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469582
Domainoid	1	1.000	78	1.000	Domainoid score	I5679
eggNOG	1	0.900	-	-		E1_28JEZ
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	106	1.000	Inparanoid score	I3502
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005301
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_115610
Panther	1	1.100	-	-	P	PTHR47327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X161
	9	8.790