DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neo and MATN3

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_002372.1	Gene:	MATN3 / 4148	HGNCID:	6909	Length:	486	Species:	Homo sapiens

Alignment Length:	351	Identity:	75/351 - (21%)
Similarity:	126/351 - (35%)	Gaps:	104/351 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AATAKEHLRIRRQAAESVTAAAPNASKVMASEEIKDK--TEWPGAKETSTEINRTE------RPV 75
            |.|.|:.|   :||...:|..:......:|.:...|:  |...||:|.|:.|.:..      ||.
Human   139 AYTDKQSL---KQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDGRPQ 200

  Fly    76 ENV-----ETRNSGFDLPAA----SDLSS--SLGSE--EDSIYYDNAPVDCNPELVGFEIVTGYV 127
            :.|     ..:.||.:|.|.    :|::|  .:.||  |:.::|..                  .
Human   201 DQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVE------------------T 247

  Fly   128 FSAPEKLMDSQPGTLMLTDCLDTC-RKNKTCQSVNYETGLCVLFSA---HADQLPGALTKSQFPV 188
            :...|||......|..   .||.| .....||.|      |:....   |.:...|
Human   248 YGVIEKLSSRFQETFC---ALDPCVLGTHQCQHV------CISDGEGKHHCECSQG--------- 294

  Fly   189 FTIYA-QKSCLAVKPC---------------SRAWYVDRVQNYKLKTEVKRTVSVASR-----RE 232
            :|:.| :|:|.|:..|               |.:::.:..:.|.| .|.::|.|...:     ..
Human   295 YTLNADKKTCSALDRCALNTHGCEHICVNDRSGSYHCECYEGYTL-NEDRKTCSAQDKCALGTHG 358

  Fly   233 CFELCLGENDFT----CR-----SANYDRTSGACELSELDRLTLAGSQAFQVNDGS-----DYLE 283
            |..:|:  ||.|    |.     :.|.|:.:  |.:.:...|...|.|...|:||:     |...
Human   359 CQHICV--NDRTGSHHCECYEGYTLNADKKT--CSVRDKCALGSHGCQHICVSDGAASYHCDCYP 419

  Fly   284 NHCVDEPNKLCEFKRLPGRILKTVDS 309
            .:.::|..|.|.......|::.|.|:
Human   420 GYTLNEDKKTCSATEEARRLVSTEDA 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453	16/81 (20%)
		PAN_AP_HGF	211..285	CDD:238532	21/92 (23%)
		PAN_1	294..373	CDD:278453	4/16 (25%)
		ZP	381..615	CDD:214579
MATN3	NP_002372.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..75
		vWFA	80..303	CDD:320736	43/202 (21%)
		FXa_inhibition	310..346	CDD:317114	5/36 (14%)
		FXa_inhibition	352..388	CDD:317114	8/39 (21%)
		FXa_inhibition	394..430	CDD:317114	9/35 (26%)
		Matrilin_ccoil	441..483	CDD:313592	2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X161
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000