DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neo and MATN1

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_002370.1	Gene:	MATN1 / 4146	HGNCID:	6907	Length:	496	Species:	Homo sapiens

Alignment Length:	369	Identity:	67/369 - (18%)
Similarity:	127/369 - (34%)	Gaps:	119/369 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 DFTCRSANYDRTSG----ACELSELDRLTLAGSQAFQVNDGSDYLENHCVDEPNKLCEFKRLPGR 302
            |.:.|:    |.||    |..:..:|:.||....:...::..||:|::.|.|            :
Human   163 DVSARA----RASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIE------------K 211

  Fly   303 ILKTVDSVYQEVSSI-----DECRELCLNSP--YRC---HSYDYNDTGDM--VCRLSHHSRAT-- 353
            :.:.....:..||.:     .:|.::|::||  |.|   ..:..|..|..  ||.....|.||
Human   212 LSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDL 276

  Fly   354 --LAD----VQEPFLEVPEASTYELTSCYNVTIECGGGDMLARIRTSKLFNGKVYAKGSPKS--- 409
              |.|    |:....|:.:....::....:|:      |.||::       |.|....|.:.
Human   277 VFLIDGSKSVRPENFELVKKFISQIVDTLDVS------DKLAQV-------GLVQYSSSVRQEFP 328

  Fly   410 -----CSVDVKSALDFELRMNYHD--------LECNVRQS------------------TAGR--- 440
                 ...|:|:|:   ..|:|.:        |:..:..|                  |.||
Human   329 LGRFHTKKDIKAAV---RNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQD 390

  Fly   441 YVNDIIIQHHDMIVTSSDLGLALACQYDLTNKSVSNGVDLDVRGDIMPALSEEVIVESPNVIMRI 505
            |:||...:       :.|||      :.:....|.|.|:.::|......::|.....
Human   391 YINDAAKK-------AKDLG------FKMFAVGVGNAVEDELREIASEPVAEHYFYT-------- 434

  Fly   506 TSRDGSDMMRSAEVGDPLALKFEIVDEQSPYEIFIRELVAMDGV 549
                 :|.....::|..|..|..:.::....|..::....::|:
Human   435 -----ADFKTINQIGKKLQKKICVEEDPCACESLVKFQAKVEGL 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453
		PAN_AP_HGF	211..285	CDD:238532	12/46 (26%)
		PAN_1	294..373	CDD:278453	19/98 (19%)
		ZP	381..615	CDD:214579	33/206 (16%)
MATN1	NP_002370.1	vWA_Matrilin	38..261	CDD:238752	24/113 (21%)
MATN1	NP_002370.1	vWA_Matrilin	272..496	CDD:238752	40/244 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X161
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000