DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment neo and cutl-25

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_497651.2	Gene:	cutl-25 / 190305	WormBaseID:	WBGene00021919	Length:	385	Species:	Caenorhabditis elegans

Alignment Length:	396	Identity:	88/396 - (22%)
Similarity:	151/396 - (38%)	Gaps:	66/396 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 PFLEV------PEASTYELTSCYNVTIECGGGDMLARIRTSKLFNGKVYAKGS--PKSCSVD--- 413
            |||.:      .||.|:|........:.|....:.....|...|.|::|.|||  ..|||..
Worm     7 PFLLIFITISSSEAKTFENRIVGKPFVSCRSDAISLVAETEDFFEGQIYVKGSRGTPSCSKSYQI 71

  Fly   414 VKSALDFELRMNYHDLE-CNVR-----QSTAGRYVNDIIIQHHDMIVTSSDLGLALACQYDLTNK 472
            .:::...||::|..:|| |..|     .|........:|:..|..:||.||......|:::...:
Worm    72 TQNSTALELKINAQELEKCGFRAWPKPNSKMWLLSGQVIVAFHPTLVTPSDRAFRAHCEFEDFKR 136

  Fly   473 SVSNGVDLDVR------GDI-MPALSEEVIVESPNVIMRITSRDGSDMMRSAEVGDPLALKFEIV 530
            ....|::..::      |:. :|.:|..::......:...|....::..:...||||:..::::.
Worm   137 KTEIGIENLIQEHELILGNFQLPKISMHILPAGEESLTTKTQNFEANEQKVLNVGDPIMFEWKLE 201

  Fly   531 DEQSPYEIFIRELVAMDGVDNSEITLIDSNGCPTDHFIMGPIYKGSVSGKMLLSNFDAFKFPSSE 595
            .|...:.|.:....|..  :|.:...|..|||..|..::..........|:..::. |||||...
Worm   202 QEHGIFGIQLERCSAES--ENGKGMKILENGCSLDEELISDTTYSQDFSKIYATSL-AFKFPEEY 263

  Fly   596 VVQFRALVTPCMPSCEPVQC---EQEDTSGE-----FRSLLSYGRKRRSLNTTDDHPRPRRDIDT 652
            .|..|..|..|:...|.::.   |:||....     |.|..|..|.||.|            :..
Worm   264 EVFIRCAVRTCVKKTEHLEIINGEEEDLCSASNNCGFVSFESSQRSRRQL------------VGK 316

  Fly   653 SKKSAPSDMLLVQSIQITDKFGFKQDKQESGDFYDGNETTFTANEEGHGFC----VNAIGLITAA 713
            :..:..:|::.|..       .|:.:||.|     ..|...|:..|   ||    :..:||.|..
Worm   317 NNNNTRTDIIYVNG-------RFRVEKQSS-----PQEARATSQTE---FCMPDVIYYLGLSTVV 366

  Fly   714 TIFLLT 719
            ..:|:|
Worm   367 ICYLIT 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453
		PAN_AP_HGF	211..285	CDD:238532
		PAN_1	294..373	CDD:278453	7/18 (39%)
		ZP	381..615	CDD:214579	55/251 (22%)
cutl-25	NP_497651.2	Zona_pellucida	35..276	CDD:391783	54/243 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910