DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment neo and cutl-1

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_506321.3	Gene:	cutl-1 / 186168	WormBaseID:	WBGene00009979	Length:	399	Species:	Caenorhabditis elegans

Alignment Length:	422	Identity:	92/422 - (21%)
Similarity:	165/422 - (39%)	Gaps:	107/422 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 ILKTVDSVYQEVSSIDECRELCLNSPYRCHSYDYNDTGDMVCRLSHHSRATLADVQEPFLEVPEA 367
            |.:|::..:.:...|.|      :|.|.||..|.:    :|.:|   ..||||....|.    :.
Worm     6 IRRTLEDYFPKGFLISE------SSKYDCHLEDMH----LVLQL---LLATLAVNPVPI----QN 53

  Fly   368 STYELTSCYNVTIECGGGDMLARIRTSKLFNGKVYAK--GSPKSCSV----DVKSALDFELRMNY 426
            |.|.     :|.:||....:..:|:|.|.|.|.::.|  .|.:.|:.    .:.:.|:.|:.:
Worm    54 SLYG-----DVQVECDSRTISVQIKTEKPFVGVIFVKDFASEEVCTSRGTGRLSAFLEIEIGL-- 111

  Fly   427 HDLECN-VRQSTAGRYVN--------DIIIQHHDMIVTSSDLGLALACQYDLTNKSVSNGVDLDV 482
                |. :||    |.:|        .|.|..|...:|..|....|.|.|..:..:|:|.:.:|.
Worm   112 ----CGALRQ----RVLNPKGLAVRTTITISFHPYFITKVDRTYNLLCLYRESQVTVANNISVDE 168

  Fly   483 RGDIMPALSEEVIVESPNVIMRITSRDGSDMMRSAEVGDPLALKFEIV------------DEQSP 535
                :..:|..|.:..|....:|.|        ....|:|  ::|.::            |::..
Worm   169 ----ISTISYNVNLTMPTCTYQILS--------GGPFGEP--VEFGLIGQQVYHQWKCDNDKEDS 219

  Fly   536 YEIFIRELVAMDGVDNSEITLIDSNGCPTDHFIMGPI-YKGSVSGKMLLSNFDA--FKFPSSEVV 597
            :.:.:......||...:.. |||||||..|.|::..: |.|:     ||:..:|  :||...:.:
Worm   220 FCMVVHTCSVDDGRGETSF-LIDSNGCSIDKFLLSNLEYPGN-----LLAGQEAHVYKFADRDAL 278

  Fly   598 QFRALVT--------PCM-PSCEPVQCEQEDTSG------EFRSLLSYG-RKRRSLNTTDDHPRP 646
            .|:..::        .|: |.||.|:.......|      ..::.:|:. |.:||..:.|:....
Worm   279 FFQCQISITVKEPDQECVRPICEDVEGGGAPVVGPPPYGFSQKTQVSFNQRAKRSETSLDEQITD 343

  Fly   647 RR---------DIDTSKKSAPSDMLLVQSIQI 669
            .|         ||.|:........:|:.::.|
Worm   344 VRTRFSVSYHFDIQTNSIEIIESCVLLSTMSI 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453
		PAN_AP_HGF	211..285	CDD:238532
		PAN_1	294..373	CDD:278453	18/69 (26%)
		ZP	381..615	CDD:214579	61/272 (22%)
cutl-1	NP_506321.3	ZP	62..300	CDD:214579	58/267 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X161
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910