DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment neo and ram-5

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_510422.2	Gene:	ram-5 / 181550	WormBaseID:	WBGene00004301	Length:	711	Species:	Caenorhabditis elegans

Alignment Length:	359	Identity:	76/359 - (21%)
Similarity:	134/359 - (37%)	Gaps:	82/359 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 IRTSKLFNGKVYAKGSPK-SCS-----VDVKSALDFELRMNY----------HDLECNVRQSTAG 439
            :.||..|: ..:..|.|: :||     |...:.:.|:.|::.          ||...|::::..
Worm    18 LATSTDFD-NAHVMGVPQVTCSAKLITVSFNTNIPFQGRISVFDKLFIPACNHDYSTNIQKNAT- 80

  Fly   440 RYVNDII--------------------IQHHDMIVTSSDLGLALACQYDLTNKSVSNGVDLDVRG 484
             :..||:                    |..|.:::|:||....:.|              ||  .
Worm    81 -FQMDILKCANPMFLKNGSRLLRAYVEIGFHPLVMTNSDRTFLVEC--------------LD--N 128

  Fly   485 DIMPALSEEVIVESPNVIMRITSRDGSDMMRSAEVGDPLALKFEI-VDEQSPYEIFIRELVAMDG 548
            .|||.::..........::|:.|...|  |...:|||.:..::.. :...:..:.|:....|:.
Worm   129 TIMPIVNRAQSFADCTHLVRMASEWSS--MSEFQVGDAIVHEWSCKLPNPAKTQTFLTNCNALS- 190

  Fly   549 VDNSEIT-LIDSNGCPTDHFIMGPI-YKGSVSGKMLLSNFDAFKFPSSE------VVQFRALVTP 605
             .|.:|. |||.|||..|..:||.| |...|  ..|.:....|||.:.:      .::|....:|
Worm   191 -QNGQIIHLIDENGCVIDSELMGDIVYSDHV--PKLYARARIFKFLTDDKYRIECTLEFCNNGSP 252

  Fly   606 CMPSCEPVQC---EQEDTSGEFRSLLSYGRKRRSLNTTDDHPRPRRDIDTSKKSAPSDMLLVQSI 667
            |.....|.:|   ::|.||...::.|    ::..:.|....|....|   |:....|..|.::..
Worm   253 CKDRVFPPKCAFTKEEITSRSTKNQL----EQSGMTTMPGIPSSAYD---SRLKISSAWLTIKLN 310

  Fly   668 QITDKFGFKQDKQESGDFYDGN-ETTFTANEEGH 700
            |.|:..|. ..:.....|.|.. ..|.:.|:..|
Worm   311 QYTETKGL-HPRYHLKTFLDPTLHETISPNDADH 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453
		PAN_AP_HGF	211..285	CDD:238532
		PAN_1	294..373	CDD:278453
		ZP	381..615	CDD:214579	57/268 (21%)
ram-5	NP_510422.2	Zona_pellucida	36..264	CDD:391783	53/251 (21%)
ram-5	NP_510422.2	PRK13042	522..>590	CDD:183854
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910