DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neo and H03E18.1

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_509443.2	Gene:	H03E18.1 / 181103	WormBaseID:	WBGene00019148	Length:	1147	Species:	Caenorhabditis elegans

Alignment Length:	821	Identity:	144/821 - (17%)
Similarity:	246/821 - (29%)	Gaps:	285/821 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 QAAESVTAAAPNASKVMA-SEEIKDKTEWPGAKETSTEINRTERPVE--NVETRNSGFDLPAASD 92
            :.|.:.|...|...|..| :||:|..|  ..||.:.......|.|||  ::||::|
Worm   386 KTAAASTKRPPTTEKPTATTEEVKSTT--AAAKPSERPTGHDETPVEENSLETKSS--------- 439

  Fly    93 LSSSLGSEEDSIYYDNAPVDCNPELVGFEIVTGYVFSAPEKLMDSQPGTL----MLTDCLDTCRK 153
                    |..|..|..          ||::       .:.||.|..|.|    .:.:|...|..
Worm   440 --------EMIIKRDGC----------FEVI-------DDHLMVSVAGGLEHDMSIEECQCMCAN 479

  Fly   154 NKTCQSVNYETGLCVLFSAHAD--------QLPGALTKSQF-PVFTIYAQKSC-----------L 198
            :||.:...::......:.|..|        .:...|.:.|| .|...|...:|           |
Worm   480 SKTSRRYEFQCRSATYYHAERDCILNLEDRNIKSKLFEKQFTDVNVTYIGLACEVDETVKSLGSL 544

  Fly   199 AVKPCSRA-----------------------WYVDRVQNYKLKTEVKRTVSVASRRECFELC--- 237
            |:..|.|.                       .||: :.::.|:.......:..:..||...|
Worm   545 ALTECRRKVEATTGEPTKETSTKKNGLKSDDCYVE-LNDFVLEGTAIAVETAVTPEECKCKCAEG 608

  Fly   238 ---LGENDFTCRSANYDRTSGACELSELDRLTLAGSQAF--QVNDGSDYLENHCVD--------- 288
               .||.   |.|..|...|..|.:::.:|.:......|  .:|....|.|..|.:
Worm   609 HKLYGEE---CASFLYYYDSKTCLINKQNRFSNPEKFNFVPSINQSRSYFEWTCANKDEARHKYR 670

  Fly   289 ------EPNKL------------------------CEFKRLPGR-ILKTVDSVYQEVSSIDECRE 322
                  ||.|:                        ...|||..: .|..:|.|.:.....::.::
Worm   671 ADVCKVEPEKVDGNLLNNESEPVVVKQDVKITEEPVPMKRLDEKAFLDKIDQVVESQEETEKKKK 735

  Fly   323 LCLNSPYRCHSYDYNDTGDMVCRLSHHSRATLADVQEPFL------------------------- 362
            :...     :|....||.:::.::......:..:.::|..
Worm   736 VTTK-----NSEHILDTDEVLKKIEKVEATSTTETEKPTTETTPATTTVTTTTEETTTPKKQEVK 795

  Fly   363 ----------------------------EVPEASTYELTSCY---------------------NV 378
                                        ||.||:|..:|:..                     :|
Worm   796 MKHMDEKALMEKINEASEKLEKSQEVTEEVTEATTEAITTTEESTTTAKLILNKKKNPTKDSGSV 860

  Fly   379 TIECGGGDMLARIRTSK-----LFNGKVYAKGSPKSCSVDVKSALDF------------ELRMNY 426
            :...|.|..:|..:|.:     |...|:     |:|.:||.:...|.            |.::..
Worm   861 SSASGNGKTVAMKKTDQKTIETLLKAKI-----PESSNVDSQEKEDINKDPRLVEMKKVEAQVLE 920

  Fly   427 HDLECNVRQSTAGRYVNDIIIQHHDMIVTSSDLGLALACQYDLTNKSVSNGV-DLDVRGDIMPAL 490
            ...:..:.:|||....:..|.::.:...|||::....|.....::...:.|: |.:|..||...|
Worm   921 KLAKMEITESTAPDSTSSTIPENIETESTSSEITKQTAKTSMKSSIPEAEGLEDDEVETDIGQEL 985

  Fly   491 S-----EEVIVESPNVIMRITSRDGSDMMRSAEVGDPLALKFEIVDEQSPYEIFIRELVAMDGVD 550
            |     ....|.:|...:.|||........:........:|....||:          :...|:.
Worm   986 STGLNDAPASVPAPESTISITSTTEKVTTTTTTQAKASGVKSHKFDEK----------IDKSGMP 1040

  Fly   551 NSEITLIDSNGC------PTDHFIMGPIYKGSVSGKMLLSNFDAFKFPSSEVVQFRALVTP--CM 607
            ...||.......      |........:|:.|..|:.||           :.|:.:   ||  |.
Worm  1041 LPRITTTTEPSTTTAGYPPAGRCSYSALYQTSFLGRRLL-----------KAVRVK---TPADCF 1091

  Fly   608 PSCEPVQCEQED--TSGEFRSLLSYGRKRRSLNTTDDHPRP 646
            .:|..::|...:  ..|||.|...|   |.||   .|:.||
Worm  1092 AACYALRCRSANLIAQGEFNSCELY---RDSL---IDYRRP 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453	18/89 (20%)
		PAN_AP_HGF	211..285	CDD:238532	16/81 (20%)
		PAN_1	294..373	CDD:278453	15/132 (11%)
		ZP	381..615	CDD:214579	49/264 (19%)
H03E18.1	NP_509443.2	PAN_AP	32..100	CDD:214680
		PAN_AP	238..316	CDD:214680
		PAN_AP_HGF	444..527	CDD:238532	18/99 (18%)
		PAN_AP	572..656	CDD:214680	17/87 (20%)
		PAN_1	1063..1139	CDD:278453	22/84 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005301
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000