DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment neo and H42K12.3

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_508240.1	Gene:	H42K12.3 / 180474	WormBaseID:	WBGene00019272	Length:	522	Species:	Caenorhabditis elegans

Alignment Length:	312	Identity:	67/312 - (21%)
Similarity:	107/312 - (34%)	Gaps:	77/312 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 SQAFQVNDGSDYLENHCVDEPNKLCEFKRLPGRILKTVDSVYQEVSSIDECRELC------LNSP 328
            |:|.:..|..:..:.|          |.......|::.|.:..:.:|.:||...|      .:.|
Worm    17 SKAVKAKDSCEESKTH----------FFVTDNASLQSADPIVYKATSEEECLSACTKNRDKFDRP 71

  Fly   329 YRCHSYDYNDTGDMVCRLSHHSRATLADVQEPFLEVPEASTYELTSC--YNVTIECGGGDMLARI 391
            ..|||:.| |.....|.:.....|.:...|   :|......|....|  :|:..:|.....: |:
Worm    72 IVCHSFTY-DHASFSCTIHKEKSAPVGSAQ---IENSVGKRYFEKICLSHNIPQQCAQTQFI-RV 131

  Fly   392 RTSKLFNGKVYA-----KGSPKSCS------VDVKSALDFELRMNYHDLECNVRQSTAGRYVNDI 445
            ..|.|..   ||     ..|.:||:      .|.|||:.|     |.|.||...:.:|.......
Worm   132 DQSVLVG---YAVNMTLTDSIESCAAQCVQEADCKSAMYF-----YEDGECITNKESAMTKPAGF 188

  Fly   446 IIQHHDMIVTSSDLGLALACQYDLTNKSVSNGVDLDVRGDIMPALSEEVIVESPN-----VIMRI 505
            ..:.:|.::                  ...||.||:.:.:  |.:..|.:.|...     :|...
Worm   189 TKEENDKVI------------------YFQNGCDLNKKNE--PTVETEEVQEEVRPVAHVLISET 233

  Fly   506 TSRDGSDMMRSA-EVGDPLALKFEIVDEQSPYEIF---IRELVAMDGVDNSE 553
            |.:..|.:.:.. |||:      |:..|..|.|.|   ..|..|..|.|..|
Worm   234 TPKPDSPVEKVVEEVGE------EVKPEMKPEEQFDEKQEETNAQTGEDEEE 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453
		PAN_AP_HGF	211..285	CDD:238532	3/14 (21%)
		PAN_1	294..373	CDD:278453	18/84 (21%)
		ZP	381..615	CDD:214579	43/193 (22%)
H42K12.3	NP_508240.1	PAN_AP	28..113	CDD:214680	19/98 (19%)
		PAN_1	127..203	CDD:278453	20/102 (20%)
		TSP1	385..424	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005301
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000