DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neo and cutl-18

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_505875.2	Gene:	cutl-18 / 179565	WormBaseID:	WBGene00009830	Length:	801	Species:	Caenorhabditis elegans

Alignment Length:	706	Identity:	141/706 - (19%)
Similarity:	245/706 - (34%)	Gaps:	188/706 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 ELVGFEIVTGYVFSAPEKLMDSQPGTLMLTDCLDTCRKNKTCQSVNYETGLCVLFSAHADQLPGA 180
            ::|.|:.:.   .....::.:...|   |..|::.|   |.|..|.|..|....:|...|. .|.
Worm   190 KMVAFDAIE---IRGESRIFNGSDG---LGKCMEKC---KDCDVVMYNEGFSECYSVWNDP-SGQ 244

  Fly   181 L---TKSQFPVFT---IYAQKSCLAVKPCSRAWYVDRVQNYKLKTEVKRTVSVASRRECFELCLG 239
            |   ...::.:.|   .|.:|:|.:    ..:.|:    :|....|       :.:.||.|.|..
Worm   245 LLDFVNDEYQILTNACSYQKKTCNS----RNSLYI----SYSNPDE-------SLKSECLEKCTM 294

  Fly   240 ENDFTCRSANYDRTSGACELSELDRLT---LAGSQAFQVN---DGSDYLENH---CVDEPNKLCE 295
            ..:  ||.|...:....|.:|. .|:.   ||......||   |||..|.:.   |.:|..:|
Worm   295 SEE--CRFAYQSKDMNNCLISR-RRMALPMLAQKICADVNDLSDGSAILFDELGGCKNENGQL-- 354

  Fly   296 FKRLPGRILKTVDSVYQEVSSIDECRELCLNSPYR-CHSYDYNDTGDMVCRLSHHSRATLAD--- 356
                   |.|.::        :.:|.:||...|.| |.|..|..:.|  |.|  |..|...|
Worm   355 -------ISKDLE--------LHQCMQLCATHPTRSCESISYTKSRD--CYL--HDGAVETDNEN 400

  Fly   357 ----------------------------VQEPF-------------LEVPEASTYELTSC----- 375
                                        |::|.             .:|.|...|...|.
Worm   401 TNCSVFTLNVITFEQELKPTTIAPGDSKVKKPHKAKTFSTGNKKDQKKVEERKLYVKKSSKLGSS 465

  Fly   376 ---YNVTIECGGGDMLARIR-----TSKLFNGKVYAKGSPKSCSVDVKSALDFELRMNYHDLECN 432
               ..::.:|..|.:..::.     ...|..|::|.:....:||..:.:..:..|::.::|..|.
Worm   466 PLDVKISTQCTFGFISVKVSPGNPDNHNLVGGEIYVRNGHSNCSKTIGTDGEAILKIRHNDTTCI 530

  Fly   433 VRQSTAGRYVNDIIIQHHDM-------IVTSSDLGLALACQYDLTNKSVSNGVDLDVRGDIMPAL 490
            .:.   |.....:::...::       ::|..|....:.|.|.....:|:....:::|......|
Worm   531 TKN---GDIYETVVVVTQNVESVGNATVITIDDQLFKVRCDYSNQKNAVAVAKTMNLRTTQFNKL 592

  Fly   491 SEEVIVESPNVIMRITSRDGSDMMRSAEVGDPLALKFEIVDEQSPYEIFIRELVAMDGVDNSEIT 555
            .....|....:.|.:..:......|:.::|..|.|.|.:.:..|...:|:::..|.|...:.:|.
Worm   593 DIYGKVNVKPMSMELRGKREIIKARTVKLGQSLDLVFTVDNSTSARHVFVKKCTAYDQNGDEKII 657

  Fly   556 LIDSNGCPTDH---FIMGPIYKGSVSGKMLLSNFDAFKFPSSEVVQFRALVTPCMPSCEPVQCEQ 617
            || .|||.|.|   :::....|.:.:|.:|  .|.||:|...|.|:....|..| ..|:...|.
Worm   658 LI-KNGCATQHAKEYVLRDEIKETATGFVL--PFRAFRFKQGEAVKIECEVKYC-EKCKKANCP- 717

  Fly   618 EDTSGEFRSLLSYGRKRRSLNTTDDHPRPRRDIDTSKKSAPSDMLLVQSIQITDKFGFKQDKQES 682
                       |..|:..:.:.::|......: ||.|..|.   ||||:|
Worm   718 -----------SRNRRFTTFDESEDTTLTGNE-DTEKVHAE---LLVQTI--------------- 752

  Fly   683 GDFYDGNETTFTANEEGHGFCVNA---IGLITAATIFLLTQ-LAVIAIWTYCYQRR 734
               .|..:.        .|:|:..   |.||:...|.:..| |.||.|   |.:.|
Worm   753 ---VDSTQL--------DGYCLQLNRWIALISLTVIIISIQFLLVIYI---CLRNR 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453	17/82 (21%)
		PAN_AP_HGF	211..285	CDD:238532	20/79 (25%)
		PAN_1	294..373	CDD:278453	21/123 (17%)
		ZP	381..615	CDD:214579	49/248 (20%)
cutl-18	NP_505875.2	PAN_AP_HGF	105..177	CDD:238532
		PAN_AP	187..258	CDD:214680	15/77 (19%)
		ZP	474..719	CDD:214579	50/263 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.970