DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment neo and noah-2

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_502699.1	Gene:	noah-2 / 178365	WormBaseID:	WBGene00009926	Length:	741	Species:	Caenorhabditis elegans

Alignment Length:	769	Identity:	166/769 - (21%)
Similarity:	281/769 - (36%)	Gaps:	230/769 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 PEKLMDSQPGTLM-----LTDCLDTCRKN--------KTCQSVNY---ETGLCVLFS-----AHA 174
            |...:|..|..:.     || |...||.|        :.|.|.|:   ||  |..|.     |..
Worm    33 PRARLDGTPVVISTAGHDLT-CAQYCRNNIEPTTGAQRVCASFNFDGRET--CYFFDDAATPAGT 94

  Fly   175 DQLPGALTKSQFPVFTIYAQKSCL----AVKPCS-RAWYVDRVQNYKLKTEVKRTVSVASRRECF 234
            .||....:.:.|     |.:|:|:    |.:.|: |::..:|.:|.:|:..||::|:|.:|..|.
Worm    95 SQLTANPSANNF-----YYEKTCIPNVSAHEACTYRSFSFERARNTQLEGFVKKSVTVENREHCL 154

  Fly   235 ELCLGENDFTCRSANYDRTSGACELSELDRLTLAGSQAFQVNDGSDYLENHCVDEPNKLCEFKRL 299
            ..||.|.:|.|:|.|:...:..||||..|:  .:.....::::..||.:|:|:...|: |.
Worm   155 SACLKEKEFVCKSVNFHYDTSLCELSVEDK--RSKPTHVRMSEKIDYYDNNCLSRQNR-CG---- 212

  Fly   300 P--GRI--LKTVD---SVYQEVSSIDE----CRELCLNSPYR-CHSYDYNDTGDMVCRLSHHSRA 352
            |  |.:  :||.:   ..|....|::.    |.:.||:|... |.|.::|.. :..|.:|.....
Worm   213 PSGGNLVFVKTTNFEIRYYDHTQSVEAQESYCLQKCLDSLNTFCRSVEFNPK-EKNCIVSDEDTF 276

  Fly   353 TLADVQ---------EPFLEVPEAST--------------------------------------- 369
            :.||.|         ||.....:.|:
Worm   277 SRADQQGQVVGKDYYEPICVAADLSSSTCRQQAAFERFIGSSIEGEVVASAQGVTISDCISLCFQ 341

  Fly   370 --------YELT--SC----------------------YNVTIECGGGDMLAR------IRTSKL 396
                    |:.|  ||                      :|...:.||..:...      :.|.:.
Worm   342 NLNCKSINYDRTASSCFIYAVGRQDANIKANPSMDYYEFNCESQFGGMALCTNEGIRFIVNTKEP 406

  Fly   397 FNGKVYAKGSPKSCSVDVKSALDFELRMNYHDLECNVRQSTAGRYVND-----IIIQHHD----- 451
            :.|.:||.....:||..|::|....:......:     .|..|..:.|     :::...|
Worm   407 YTGAIYAAERFSTCSQVVENAKQISITFPPPTV-----SSDCGTVIRDGKMEALVVVSLDGVLPH 466

  Fly   452 MIVTSSDLGLALACQYDLTNKSVSNG---------------VDLDVRGDIMPALSEEVIV----E 497
            .:.|..|....::|...: :|.|..|               ..|||.  ..|.:|.|:.:    |
Worm   467 QVTTEWDRFYRVSCDVSM-DKMVKEGSVVVTTIYEASSQNTTVLDVA--TPPPVSAELQILNQLE 528

  Fly   498 SPNVIMRITSRDGSDMMRSAEVGDPLALKFEIVDEQS-PYEIFIRELVA--MDGV-DNSEITLID 558
            .|              :..|.:||||.|  .|..||: |:.:.:.|..|  :.|. |....|||:
Worm   529 EP--------------LHKASIGDPLLL--VITSEQAGPHNMMVTECTATRVGGFGDTVPFTLIE 577

  Fly   559 SNGCPTDHFIMGPIYKGSVSGKMLLSNFDAFKFPSSEVVQFRALVTPCM-PS-CEPVQCEQEDTS 621
             ||||....::||: :.......|.|:..||:...|..||....:..|. |: |....|....|:
Worm   578 -NGCPRYPALVGPV-EQDFDKNRLKSDLRAFRLDGSYDVQIVCSIMFCAGPNGCPVSNCLDSGTN 640

  Fly   622 GEFRSLLSYGRKRRSLNTTDDHPRPRRDIDTSKKSAPSDMLLVQSIQITDKFGFKQDKQESGDFY 686
            ..|   :|:|||:||           .|::..:    ::..|...|::   |...:|::|   ..
Worm   641 ELF---MSHGRKKRS-----------ADLEAGE----TEEKLSAIIRV---FAKGEDEEE---ME 681

  Fly   687 DGNETTFTA-NEEGHGFCVNA---IGLITAATIFLLTQLAVIAIWTYCYQRRQK 736
            ..|.|..|: ::.....|:..   :..:.:.::......|:||||. |:....|
Worm   682 MANNTMMTSMSDSTELLCIAEPFFVSSVVSLSVLCFALSAIIAIWG-CHSLHSK 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453	22/86 (26%)
		PAN_AP_HGF	211..285	CDD:238532	23/73 (32%)
		PAN_1	294..373	CDD:278453	23/146 (16%)
		ZP	381..615	CDD:214579	61/274 (22%)
noah-2	NP_502699.1	PAN_1	28..112	CDD:278453	22/86 (26%)
		PAN_AP_HGF	125..203	CDD:238532	24/79 (30%)
		PAN_AP_HGF	217..292	CDD:238532	16/75 (21%)
		PAN_1	310..382	CDD:278453	4/71 (6%)
		ZP	392..634	CDD:214579	59/267 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157397
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JEZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840