DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment neo and let-653

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_001021336.2	Gene:	let-653 / 178120	WormBaseID:	WBGene00002827	Length:	812	Species:	Caenorhabditis elegans

Alignment Length:	435	Identity:	83/435 - (19%)
Similarity:	140/435 - (32%)	Gaps:	155/435 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 LMLTDCLDTCR---------KNKTCQSVNYETG------LCVLFSAHADQLPGALTKSQFPVFTI 191
            |.|..|...|.         |...|.:||::..      ||.:|..|..|......::. ..||.
Worm    48 LSLKGCQSACSLGEDPVSPGKQLECAAVNHQASPDGFSHLCAVFQPHQLQNVDGYVEAD-DRFTF 111

  Fly   192 YAQKSCL-AVKPCSRAW--------YVDRVQNYKLKTEVKRTVSVASRRECFELCLGENDFTCRS 247
            | .|.|| :.:.||..:        |:|:      |:.:|.|.. |:..||...||.|..|.|||
Worm   112 Y-WKYCLPSTRKCSGEYAFTYLSDRYMDQ------KSVIKWTTK-ANLEECLSDCLDEKSFECRS 168

  Fly   248 ANYDRTSGACELSELDRLTLAGSQAFQVNDGS----DYLENHCVDEPNKLCEFKRLPGRILKTVD 308
            .:::||.|.|.:|:..:  ::..:|.::|:..    ||.||:|
Worm   169 ISFNRTDGGCHMSKDSQ--ISRPEAIRLNNNPNYRIDYYENNC---------------------- 209

  Fly   309 SVYQEVSSIDECRELCLNSPYRCHSYDYNDTGDMVCRLSHHSRATLADVQEPFLEVPEASTYELT 373
                                                                         |.|:
Worm   210 -------------------------------------------------------------YNLS 213

  Fly   374 SCYNVTIECGGGDMLARIRTSKLFNGKVYAKGSPKSCSVDVKSALDFELRMNYHDLECNVRQSTA 438
            ..:....||....:...:::...:.|.:|......:|..:.|.|.:|:....|..:..|...|.
Worm   214 ESFTFKHECRDNGISVSVKSRLPYTGAIYGLYDFFTCRTEPKEATEFDHFFPYQTVSKNCSDSI- 277

  Fly   439 GRYV-NDIIIQHHDMIVTSSDLG---LALACQYDLTNK--------------SVSNGVDLDVRGD 485
             :|. |:::::    :|.|:| |   |......|||.:              :..:...||.|..
Worm   278 -KYKGNEMVLE----VVLSTD-GIEPLYFITPEDLTYQAKCPISGVKAKDPANTKSSAHLDNRNK 336

  Fly   486 IMPALSEEVIVESPNVIMRITSRDGSDMMRSAEVGDPLALKFEIV 530
            .|.|        |.:.:..:.|:.|.|.........||....|::
Worm   337 AMEA--------SAHALFELLSKTGDDEALQNTFPLPLTTTTEVI 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453	17/69 (25%)
		PAN_AP_HGF	211..285	CDD:238532	23/77 (30%)
		PAN_1	294..373	CDD:278453	1/78 (1%)
		ZP	381..615	CDD:214579	33/168 (20%)
let-653	NP_001021336.2	PAN_AP_HGF	124..208	CDD:238532	26/92 (28%)
let-653	NP_001021336.2	ZP	<606..727	CDD:214579
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157398
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47327
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030