DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment neo and fbn-1

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_001263709.1	Gene:	fbn-1 / 176076	WormBaseID:	WBGene00022816	Length:	2781	Species:	Caenorhabditis elegans

Alignment Length:	842	Identity:	165/842 - (19%)
Similarity:	285/842 - (33%)	Gaps:	212/842 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VTAAAPNASKVMASEEIKDKTEWP--GAKETSTEINRTERPVENVETRNSGFDLPAASDLSSSLG 98
            :..|||:    ..:|...:.:|.|  .||.:.|:...|.:|.....|...    ||.:.......
Worm  2001 ILTAAPS----KPTESTTESSEAPTTPAKTSETKSLTTPQPPPTTTTTAK----PATTSGKRGPP 2057

  Fly    99 SEEDSIYYDNAPVDCNPELVGFEIVTGYVFSAPEKLMDSQPGTLMLTDCLD-TCRKNKTCQSVNY 162
            |.:........|....|...|:    |...:..|:.:.|...|...:.|.. ||....||:.
Worm  2058 SIQPPAEMFTTPAPPPPSNGGY----GEETNQEEEQVTSTTTTEAPSLCSTVTCHSLATCEQ--- 2115

  Fly   163 ETGLCVLFSAH-ADQLPGALTKSQFPVFTI-----------YAQKSCLAVKPCSRAWYVD----- 210
            .||:|:..... .|.......||.....::           .:.:||    .|...:..|
Worm  2116 STGVCICRDGFIGDGTTACSKKSTADCISLPSLCADKAKCDNSTRSC----ECDAGYIGDGYVCS 2176

  Fly   211 -RVQNYKLKTEVKRTVSVASRRECFEL----------------------------CLGENDFTCR 246
             ..|:..|:..:....:|...|.|..|                            |:|..  ||:
Worm  2177 PHPQDCVLRDNLCSPEAVCQNRRCQCLPGFTGDGVKCVSIHERASNCSQCDANAHCVGGT--TCK 2239

  Fly   247 -SANYDRTSGACELSELDRLTLAG-----------------SQAFQVNDGSDYLENHC-----VD 288
             :..|......|....||.:...|                 |..|..|..|.:.:..|     |.
Worm  2240 CNPGYFGNGLCCVPDPLDCVHFTGICHPNAVCNSESRQCQCSSGFSGNGVSCFPQKSCRTDKSVC 2304

  Fly   289 EPNKLC----------EFKRLP----GRILKTVDSVYQEVSSIDECRELCLNSPYRCHSYDYNDT 339
            ..|.:|          .||..|    ..::....:..|::|.:..|...|.:|...|.|
Worm  2305 AKNAICLPTGSCICRHGFKGDPFYKCSSLVSKEPANQQDLSDVSSCVTPCDSSTQLCIS------ 2363

  Fly   340 GDMVCRLSHHSRATLADVQEPFLEVPEASTY-----ELTSCYNV----TIECGGGDM------LA 389
            |:.:|:......:||:. .|...::.|.:..     .:.:|.|.    ...|..|.:      :.
Worm  2364 GECICKSGFRRNSTLSG-SETCADIDECAEKSHKCDRVATCRNTFGSHVCTCPDGHVGDGITCVP 2427

  Fly   390 RIRTSKL-------------------FNGKVYAKGSPKS--CSVDVKSALD------FELRMNYH 427
            .:...||                   |.||::.||..::  ||....|.|:      |::...:
Worm  2428 HVNQGKLSVYCEADGMTLVLGNETADFEGKIFVKGQAENPYCSKSFSSLLNSRKPYVFKVVFQH- 2491

  Fly   428 DLECNVRQSTAGRYVNDIIIQHHDMIVTSSDLGLALACQYDLTNKSVSNGVDLDVRGDIMPALSE 492
               |:|:........:.:::|.|.|.:|:......|.|||.:.:::|.:.|::.... ....|:|
Worm  2492 ---CDVQLLDNHTMASTVVVQKHAMFLTNKADSYDLRCQYPIGSRAVESHVNVSELA-TTSTLTE 2552

  Fly   493 EVIVESPNVIMRIT-SRDGSDMMRSAEVGDPLALKFEIVDEQSPYEIFIRELVAMDGVDNSEITL 556
            :....:|  |.|:: |.|....:.||.|||.|.|..|:...:: :.|..|...|::.......||
Worm  2553 KNSTLAP--ICRLSVSNDQHSSISSAMVGDTLKLALEVTPSEN-FGILPRNCFAINIESGERYTL 2614

  Fly   557 IDSNGCPTDHFIMGPIYKGSVSGKMLLSNFDAFKFPSSEVVQFRALVTPCMPSCEPVQCEQEDTS 621
            .|..||..|..:. |.:..:.|.| :.:.|..||:|.|.:::|:....||:..|....|
Worm  2615 TDDMGCAIDESLF-PQWSAATSSK-VQAVFRTFKWPDSSMIRFQCDCNPCVGQCSTPTC------ 2671

  Fly   622 GEFRSLLSYGRKRRSLNTT---DDHPRPRRDIDTSKKSAPSDMLL---VQSIQITDKFGFKQDKQ 680
                  :|..|.||...|:   :|..|             .:|:|   |:|:.::...    :..
Worm  2672 ------ISSARFRRHQTTSPVVNDEIR-------------QEMVLMSGVESLAVSSII----NVH 2713

  Fly   681 ESGDFYDGNETTFTA------NEEGHGFCVNAIGLITAATIFLLTQLAVIAIWTYCYQRRQK 736
            :|.|....::...|:      ::|....||....|:.|...|.:..    ||..|...::.|
Worm  2714 DSHDMNTSDDDDVTSSHVDATSKESKSICVKMAPLLIALGSFAVCS----AILLYLCSKKPK 2771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453	15/89 (17%)
		PAN_AP_HGF	211..285	CDD:238532	19/119 (16%)
		PAN_1	294..373	CDD:278453	17/97 (18%)
		ZP	381..615	CDD:214579	62/267 (23%)
fbn-1	NP_001263709.1	EGF_3	140..170	CDD:289699
		EGF_CA	172..210	CDD:214542
		EGF_CA	220..>255	CDD:284955
		EGF_3	309..342	CDD:289699
		EGF_CA	344..381	CDD:214542
		Herpes_BLLF1	<918..1383	CDD:282904
		DUF2413	1276..>1371	CDD:287302
		EGF_CA	1433..1472	CDD:284955
		EGF_CA	1475..1516	CDD:214542
		EGF_3	1571..1606	CDD:289699
		EGF_CA	1608..1642	CDD:238011
		EGF_CA	1701..1742	CDD:214542
		EGF_CA	1743..1783	CDD:214542
		EGF_CA	1881..>1914	CDD:284955
		EGF_3	2258..2291	CDD:289699	4/32 (13%)
		EGF_3	2390..2425	CDD:289699	4/34 (12%)
		ZP	2438..2674	CDD:214579	59/257 (23%)
		Zona_pellucida	<2578..2671	CDD:278526	27/95 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910