DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment neo and cut-1

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_496410.1	Gene:	cut-1 / 174720	WormBaseID:	WBGene00000851	Length:	424	Species:	Caenorhabditis elegans

Alignment Length:	438	Identity:	86/438 - (19%)
Similarity:	142/438 - (32%)	Gaps:	117/438 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   380 IECGGGDMLARIRTSKLFNGKVYAKG--SPKSCSVDV--KSALDFELRMNYHDLECNVRQSTA-- 438
            :|||...:.....|...|.|.||.||  ....|..|.  :.....||..:    .||..::.:
Worm    31 VECGPNSITVNFNTRNPFEGHVYVKGLYDQAGCRSDEGGRQVAGIELPFD----SCNTARTRSLN 91

  Fly   439 --GRYVN-DIIIQHHDMIVTSSDLGLALACQYDLTNKSVSNGVDLDVRGDIMPALSEEVIVESPN 500
              |.:|: .::|..|...||..|....:.|.|..::|:||..:::   .|:..|...:|:   |.
Worm    92 PKGVFVSTTVVISFHPQFVTKVDRAYRIQCFYMESDKTVSTQIEV---SDLTTAFQTQVV---PM 150

  Fly   501 VIMRITSRDG---SDMMRSAEVGDPLALKFEIVDEQSPYEIFIRELVAMDGVDNSEITLIDSNGC 562
            .:.:....||   ...::.|.:|..:..|:....|.:.....:.....:|..:...:.:::..||
Worm   151 PVCKYEILDGGPSGQPIQFATIGQQVYHKWTCDSETTDTFCAVVHSCTVDDGNGDTVQILNEEGC 215

  Fly   563 PTDHFIM--------------GPIYK--------------------GSVSGKMLLS---NFDAFK 590
            ..|.|::              ..:||                    ||...:...|   .|.|.|
Worm   216 ALDKFLLNNLEYPTDLMAGQEAHVYKYADRSQLFYQCQISITIKDPGSECARPTCSEPQGFGAVK 280

  Fly   591 -----------FPSSEVVQFRAL-VTPCMPSCEPVQCE------QEDTSGEFRSLLSYGRKRRSL 637
                       .|.:.|.:.:|. |....|...||...      ...|..:.|.|    ||:||.
Worm   281 QAGAGGAHAAAAPQAGVEEVQAAPVAAAAPVAAPVAAAAAAPAVPRATLAQLRLL----RKKRSF 341

  Fly   638 NTTDDHPRPRRDIDT------SKKSAPSDMLLVQSIQITDKFGFKQDKQESGDFYDGNETTFTAN 696
            ...:.....|.:|:|      :..|||....||                        :|.:....
Worm   342 GENEGILDVRVEINTLDIMEGASPSAPEAAALV------------------------SEESVRRR 382

  Fly   697 EEGHGFCVNAIGLITAATIFLLTQLAVIAIWTYCYQRRQKLQPYQHSY 744
            ....|.|:..||..:...|..:...|:.|  |..|..|    |..|.:
Worm   383 ATSTGICLTPIGFASFLGIGTIVATALSA--TIFYVAR----PTSHKH 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453
		PAN_AP_HGF	211..285	CDD:238532
		PAN_1	294..373	CDD:278453
		ZP	381..615	CDD:214579	58/294 (20%)
cut-1	NP_496410.1	ZP	32..271	CDD:214579	47/248 (19%)
cut-1	NP_496410.1	Zona_pellucida	<171..271	CDD:278526	12/99 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X161
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910