DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neo and cutl-9

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_496293.2	Gene:	cutl-9 / 174640	WormBaseID:	WBGene00010893	Length:	562	Species:	Caenorhabditis elegans

Alignment Length:	708	Identity:	144/708 - (20%)
Similarity:	232/708 - (32%)	Gaps:	253/708 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 GSEEDSIYYDNA----P-VDCNPELVGFEIVTGYVFSAPEKLMDSQPGTLMLTDCLDTCRKNKTC 157
            |:.:.:..:|||    | :.|..:.:..|::|..:|:....:    .|......|..|.| |...
Worm    23 GAGKSASAFDNAIIGQPYISCQRDRIVIEVITERLFTGKVFV----KGDYANPQCTKTFR-NGVA 82

  Fly   158 QS---VNYETGLCVLFSAHADQLPGALTKSQFPVFTIYAQKSCLAVKPCSRAWYVDRVQNYKLKT 219
            .|   :..||.|            |.:|||:.|    |.:....|.:..|.:...::.||.|..:
Worm    83 SSGGHIEDETFL------------GTVTKSREP----YVEDHLKASRGSSDSKISNQYQNQKATS 131

  Fly   220 EV------KRTVSVASRRECFELCLGENDFTCRSANYDRTSGACELSELDRLTLAGSQAFQVNDG 278
            ..      |....:.::.:.|.    |||                                :|..
Worm   132 NTNFEHASKSGTDLGTKSKTFH----END--------------------------------INSA 160

  Fly   279 SDYLENHCVDEPNKLC------EFKRLPG-----------------RIL-KTVDS---------- 309
            .|..|...:...|:..      |:|.:.|                 |:. |:|.|
Worm   161 PDIAETFLLPRKNETTSDTDEGEWKGIGGASAGGNAIFGGTRGEELRVFGKSVTSSSTRSRPGST 225

  Fly   310 VYQEVSSIDECRELCLNSPYRCHSYDYNDTGDMVCRLSHHSRATLADVQEPFLEVPEASTYELTS 374
            :....||..:|..|...:|..|                 ..|.|........||||      |.|
Worm   226 LPLSTSSSPDCPPLTTCAPCAC-----------------EERRTRRATNSIRLEVP------LNS 267

  Fly   375 CYNVTIECGGGDMLARIRTSKLFNGKVYAKGSPKSCSVDVKSALDFELRMNYHDLECNVRQSTAG 439
            |                      |.|...|.:|.|..|.:.:.:.|
Worm   268 C----------------------NTKRDRKLNPPSVVVSLIAVVSF------------------- 291

  Fly   440 RYVNDIIIQHHDMIVTSSDLGLALACQYDLTNKSVSNGVDLDVRGDIMPALSEEV--IVESPNVI 502
                      ||..:|..|....:.|.|....|:||..:|:::..:      :|:  .||.|:..
Worm   292 ----------HDSFITKLDKAYHIQCAYAEAEKTVSTDLDVNMTDE------QEINGTVEPPSCD 340

  Fly   503 MRITSRDGSDMMRSAEVGDPLALKFEIVDEQ--------SPYEIFIRELVAMDGVDNSEITLIDS 559
            ..|:.::|:.:..|. ||       |:|..|        :..::.:.:....||. ..:..:||.
Worm   341 YLISDQNGNSVQNSL-VG-------ELVRHQWVCKGGLTNKLKMLVHQCYVKDGA-GQQFEVIDQ 396

  Fly   560 NGCPTDHFIM-GPIYKGSVSGKMLLSNFDA--FKFPSSEVVQFRALVTPCMPSCEPVQC--EQED 619
            :||..|..:: .|.|  |..|  :.:..||  ||||....|.||..:|.|  |.:..:|  ....
Worm   397 HGCTLDQLMLQTPTY--SEDG--MSAQVDAYIFKFPDRSTVDFRCTITFC--SVDDAECLDMTPP 455

  Fly   620 TSGEFRSLLSYGRKRRS---LNTTDDHPRPRR--DIDTSKKSA----PSDMLLVQSIQITDKFGF 675
            ..|...:||.  ||:||   |::...|.....  |||:||...    |:..||.::
Worm   456 KCGANNNLLR--RKKRSSHGLSSMSLHANSLTVFDIDSSKTDTNQLLPTPALLRKT--------- 509

  Fly   676 KQDKQESGDFYDGNETTFTANEEGHGFCVNAIGLITAATIFLLTQLAVIAIWTYCYQR 733
                      ::..|.||..:....|.      ||:|:|.|....:||  |::|.:.|
Worm   510 ----------FEEYERTFCVSVASFGI------LISASTFFATISIAV--IFSYFFLR 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453	18/79 (23%)
		PAN_AP_HGF	211..285	CDD:238532	11/79 (14%)
		PAN_1	294..373	CDD:278453	19/112 (17%)
		ZP	381..615	CDD:214579	52/246 (21%)
cutl-9	NP_496293.2	ZP	244..460	CDD:214579	65/310 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X161
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910