DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neo and noah-1

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_001250022.1	Gene:	noah-1 / 172261	WormBaseID:	WBGene00016422	Length:	1052	Species:	Caenorhabditis elegans

Alignment Length:	821	Identity:	174/821 - (21%)
Similarity:	295/821 - (35%)	Gaps:	224/821 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 ASDLSSSLG-----SEEDSIYYDN----APVDCN--------PE--LVGFEIVTGYVFSAPEKLM 135
            |.:.|..||     :.|...|::.    :|..|.        |:  ||||...          :|
Worm   258 ADERSKPLGRADLIATEGFTYFEKKCFASPNTCRNVPSFKRVPQMILVGFAAF----------VM 312

  Fly   136 DSQPGTLMLTDCLDTCRK-------NKTCQSV--NYETGLCVLFSAHADQLPGALTKSQFPVFTI 191
            ::.|...|   |||.|..       ...|:||  .|....|:|.|...:..|.............
Worm   313 ENVPSVTM---CLDQCTNPPPETGDGFVCKSVMYYYNEQECILNSETRESKPELFIPEGEEFLVD 374

  Fly   192 YAQKSC-LAVKPCSRAWYVDRVQNY-------KLKTEVKRTVSVASRRECFELCLGENDFTCRSA 248
            |...:| |..:.|....::..::..       :.:..|.:..:....:||...|.|.....|||.
Worm   375 YFDITCHLKQEKCPTGQHLKAIRTINAALPEGESELHVLKASAAKGIKECVAKCFGLAPEKCRSF 439

  Fly   249 NYDRTSGACELSELDRLTLAGSQAF--QVNDGSDYLENHCVDEPNKLCE-------FKR------ 298
            |||:.:.:|:|..||     |....  ||..|.|..:.||:...|. |.       |.|
Worm   440 NYDKKTKSCDLLYLD-----GHNTLQPQVRQGVDLYDLHCLAVEND-CSANKDDALFSRYLHTKQ 498

  Fly   299 --LPGRILKTVDSVYQEVSSIDECRELCLNSPYRCHSYDYN------------------------ 337
              :|.::.|.|        |::.|.|:|..:| .|...:||
Worm   499 RGIPAKVYKVV--------SLNSCLEVCAGNP-TCAGANYNRRLGDCTLFDAIDDDAEINEHTDF 554

  Fly   338 ----------DTGDM----VCRLSHHSRATLAD-------------VQEPFLE------VPEAST 369
                      |||..    |....|....|:.:             |::|.::      .|| ||
Worm   555 YKNLCVTKEIDTGASAAANVPETKHRVSGTVVEGKDSKSQLLATKKVKKPTIKNTEHRRAPE-ST 618

  Fly   370 YELTSCYNVTIE-----CGGGDMLARIRTSKLFNGKVYAKGSPKSCSVDVKSA----------LD 419
            ..:.....|..|     |....:..:|...:.|:|.::.|....:|.|:|.::          .|
Worm   619 VPIGPPVEVKAEAIQTICNYEGIKVQINNGEPFSGVIFVKNKFDTCRVEVANSNAATLVLGLPKD 683

  Fly   420 FELRM----NYHDLE--------------------------------CNVRQSTAGRYVNDIIIQ 448
            |.:|.    |..|.|                                |.:.....|.|.:.::||
Worm   684 FGMRPISLDNIDDNETGKNKTKKGEETPLKDEIEEFRQKRQAAEFRDCGLVDLLNGTYKSTVVIQ 748

  Fly   449 HHDM----IVTSSDLGLALACQY-DLTNKSVSNGVDLDVRGDIMPALSEEVIVESPN-VIMRITS 507
            .:::    :|||.|....::|.| .:....|..|.::.|.|.....:.....:|..| |:|::.:
Worm   749 TNNLGIPGLVTSMDQLYEVSCDYSSMLGGRVQAGYNMTVTGPEANLIQPRGKIELGNPVLMQLLN 813

  Fly   508 RDGSDM-MRSAEVGDPLALKFEIVDEQSPYEIFIRELVAMDGV------DNSEITLIDSNGCPTD 565
            .||::. :..|::||.|.|::||:......:.|::...|..||      ...::.||| .||||.
Worm   814 GDGTEQPLVQAKLGDILELRWEIMAMDDELDFFVKNCHAEPGVAGGKAGAGEKLRLID-GGCPTP 877

  Fly   566 HFIMGPIYKGSV---SGKMLLSNFDAFKFPSSEVVQFRALVTPCMPSCEPVQCEQEDTSGEFRSL 627
             .:...:..|::   |..:..:...||:|.||..::....|..|...||||:|..  |.|..:
Worm   878 -AVAQKLIPGAIEIKSSAVKTTKMQAFRFDSSASIRVTCEVEICKGDCEPVECAL--TGGVKK-- 937

  Fly   628 LSYGRKRRSLNTTDDHPRPRRDIDTSKKSAPSDMLLVQSI-QITDKFG--FKQDKQESGDFY--D 687
             |:|||:|.::...:.....|.:...:..|.:.::::..: |:..|..  ....:..:.|..  |
Worm   938 -SFGRKKREVSNNIEEFETNRYLIPRRSHATTSIVIIDPLQQVCTKVNEPVAMSRASTLDLLRED 1001

  Fly   688 GNETTFTANEEGHGFCVNAI---GLITAATIFLLTQLAVIA 725
            .:|....  ||| ..|:|::   .:.....:.:|.|..|||
Worm  1002 AHEVQMI--EEG-SICLNSVTVFAIFGTLAVLILGQTVVIA 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453	17/85 (20%)
		PAN_AP_HGF	211..285	CDD:238532	20/82 (24%)
		PAN_1	294..373	CDD:278453	26/150 (17%)
		ZP	381..615	CDD:214579	67/300 (22%)
noah-1	NP_001250022.1	PAN_AP_HGF	107..189	CDD:238532
		PAN_AP_HGF	201..282	CDD:238532	6/23 (26%)
		PAN_AP_HGF	295..379	CDD:238532	21/96 (22%)
		PAN_AP_HGF	391..473	CDD:238532	20/86 (23%)
		PAN_APPLE	485..557	CDD:294081	13/80 (16%)
		Zona_pellucida	<818..920	CDD:278526	26/103 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I5679
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005301
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010