DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment neo and AgaP_AGAP002316

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	XP_312656.5	Gene:	AgaP_AGAP002316 / 1273654	VectorBaseID:	AGAP002316	Length:	795	Species:	Anopheles gambiae

Alignment Length:	771	Identity:	481/771 - (62%)
Similarity:	595/771 - (77%)	Gaps:	48/771 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LRHLFLALMLYSAATAKEHLRIRRQAAE---SVTAAAP---NASKVMASEEIKDKTEWPGAKETS 65
            ||.|.|..:|.::::.......||...:   |..|.||   |.:....:|...::.|.|.|
Mosquito     6 LRSLLLTCLLLASSSPSIDAAKRRSRLDLPISKPADAPLEDNLATASGAEPAYERVEAPAA---- 66

  Fly    66 TEINRTERPVENVETRNSGFDLPAASDLSSSLGSEEDSIYYDN-APVDCNPELVGFEIVTGYVFS 129
                  ..|.....:..:..:..::::.|.|..||..|...|. :..:|:|:.:.||:|||||||
Mosquito    67 ------ITPAAAATSAGTSAETESSANASGSGSSENSSQMIDEYSDEECDPDFIAFELVTGYVFS 125

  Fly   130 APEKLMDSQPGTLMLTDCLDTCRKNKTCQSVNYETGLCVLFSAHADQLPGALTKSQFPVFTIYAQ 194
            ||.||:||.||||||||||:.|:.|.:|.|||||||||||||:::|:||||||||||||||||||
Mosquito   126 APNKLLDSMPGTLMLTDCLEACQNNDSCASVNYETGLCVLFSSNSDKLPGALTKSQFPVFTIYAQ 190

  Fly   195 KSCLAVKPCSRAWYVDRVQNYKLKTEVKRTVSVASRRECFELCLGENDFTCRSANYDRTSGACEL 259
            ||||.::||.|||.:||||.|||...||||..|.|||:|.|:|||||:|||||||:.:|:..|||
Mosquito   191 KSCLKLRPCERAWCIDRVQGYKLNGHVKRTAQVVSRRDCIEMCLGENEFTCRSANFYQTTMTCEL 255

  Fly   260 SELDRLTLAGSQAFQVNDGSDYLENHCVDEPNKLCEFKRLPGRILKTVDSVYQEVSSIDECRELC 324
            |::||:|||||.|||.|||:|||||:|.:||.||||||||.||||||||||||:|:|:|||||||
Mosquito   256 SDMDRITLAGSSAFQTNDGADYLENNCAEEPTKLCEFKRLSGRILKTVDSVYQDVASVDECRELC 320

  Fly   325 LNSPYRCHSYDYNDTGDMVCRLSHHSRATLADVQEPFLEVPEASTYELTSCYNVTIECGGGDMLA 389
            |:||||||||||.|||||||||||||||||:|:|:|:|:||||:||||:|||||:|||..|||:|
Mosquito   321 LSSPYRCHSYDYGDTGDMVCRLSHHSRATLSDIQDPYLDVPEAATYELSSCYNVSIECRAGDMIA 385

  Fly   390 RIRTSKLFNGKVYAKGSPKSCSVDVKSALDFELRMNYHDLECNVRQSTAGRYVNDIIIQHHDMIV 454
            :|||||||:|||||||||.||||||||:|:|||||.|.|::|||||:..|||:||::|||||.||
Mosquito   386 KIRTSKLFDGKVYAKGSPNSCSVDVKSSLEFELRMGYQDIDCNVRQNGLGRYLNDVVIQHHDTIV 450

  Fly   455 TSSDLGLALACQYDLTNKSVSNGVDLDVRGDIMPALSEEVIVESPNVIMRITSRDGSDMMRSAEV 519
            ||||||||:.||||||||:|||.|||||.|||.|||||||:|:||||:|:||:||||:|||:|||
Mosquito   451 TSSDLGLAVTCQYDLTNKTVSNDVDLDVTGDIEPALSEEVVVDSPNVVMKITTRDGSEMMRTAEV 515

  Fly   520 GDPLALKFEIVDEQSPYEIFIRELVAMDGVDNSEITLIDSNGCPTDHFIMGPIYKGSVSGKMLLS 584
            ||||||:|||:|.|||||||:||||||||||:|||||||:.||||||||||||||.:.|||:|||
Mosquito   516 GDPLALRFEILDPQSPYEIFVRELVAMDGVDSSEITLIDARGCPTDHFIMGPIYKSASSGKILLS 580

  Fly   585 NFDAFKFPSSEVVQFRALVTPCMPSCEPVQCEQEDTSGEFRSLLSYGRKRRSLNTT-----DDHP 644
            :||||||||||:||||||||||||:||||||:|:|..||.||::||||||||:|.|     :...
Mosquito   581 HFDAFKFPSSEMVQFRALVTPCMPTCEPVQCDQDDFGGELRSMVSYGRKRRSVNATTSAVLEAVA 645

  Fly   645 RPRRDIDTSKKSAPSDMLLVQSIQITDKFGFKQDKQESGDFYDGNETTFTANEEGHGFCVNAI-- 707
            |.||  :|::::...||||||||||||||||:: :|.:......:||.|.|| :|.|.|||.:
Mosquito   646 RHRR--ETTRQAPQDDMLLVQSIQITDKFGFEK-QQGAKPKLSSSETVFVAN-DGQGICVNGLGK 706

  Fly   708 --------------------GLITAATIFLLTQLAVIAIWTYCYQRRQKLQPYQHS 743
                                |||.|..:|||.||||||||||.:|||:|.:.::::
Mosquito   707 YARTIDRLEPNANVPVLSSAGLIVAGAVFLLGQLAVIAIWTYLWQRRRKQRQFENA 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453	61/76 (80%)
		PAN_AP_HGF	211..285	CDD:238532	50/73 (68%)
		PAN_1	294..373	CDD:278453	66/78 (85%)
		ZP	381..615	CDD:214579	187/233 (80%)
AgaP_AGAP002316	XP_312656.5	PAN_1	115..193	CDD:278453	61/77 (79%)
		PAN_AP_HGF	200..281	CDD:238532	54/80 (68%)
		PAN_1	290..>352	CDD:278453	55/61 (90%)
		ZP	377..612	CDD:214579	188/234 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	516	1.000	Domainoid score	I1102
eggNOG	1	0.900	-	-		E1_28JEZ
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H16864
Inparanoid	1	1.050	961	1.000	Inparanoid score	I994
OMA	1	1.010	-	-		QHG28231
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005301
OrthoInspector	1	1.000	-	-		oto110552
Panther	1	1.100	-	-	O	PTHR47327
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.930