DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment neo and matn4

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	XP_002938060.3	Gene:	matn4 / 100492840	XenbaseID:	XB-GENE-990978	Length:	702	Species:	Xenopus tropicalis

Alignment Length:	698	Identity:	131/698 - (18%)
Similarity:	215/698 - (30%)	Gaps:	271/698 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 TEWPGAKETSTEINRTE------RPVEN-----VETRNSGFDLPAA----SDLSS--SLGSE--E 101
            ||..||:..|..|.|..      ||.:.     |:.|.:|.::.|.    :|:||  ::.|.  :
Frog   128 TEEEGARPLSKNIPRVAIIVTDGRPQDRVTEVAVQAREAGIEIYAVGVQRADVSSLRAMASHPLD 192

  Fly   102 DSIYYDNAPVDCNPELVGFEIVTGYVFSAPEKLMDSQPGTLMLTDCLDTCRK-NKTCQSVNYETG 165
            |.:::          :..|:::........:||           .|:|.|.: :..||.
Frog   193 DHVFH----------VESFDLIQHLSIQFQDKL-----------SCVDMCTEMDHGCQH------ 230

  Fly   166 LCVLFSAHADQLPGALTKSQFPVFTIYAQKSCLAVKPCSRAWYVDRVQNYKLKTEVKRTVSV--- 227
            .||       .:|.                          ::|.:..:.|||..:.| |.|:
Frog   231 KCV-------NIPS--------------------------SYYCECNEGYKLNADGK-TCSLIDL 261

  Fly   228 --ASRRECFELCL---GENDFTCRSA---NYDRTSGACELSELDRLTLAGSQAFQVNDGSDYLEN 284
              .....|.::|:   |....|||:.   |.|:.:  |.|.:|            .:.|:...|.
Frog   262 CAQGNHGCEQICVSSPGSYSCTCRAGYQLNEDKKT--CSLIDL------------CSQGNHGCEQ 312

  Fly   285 HCVDEPN----------KLCEFKRLPGRILKTVDSVYQEVSSID-------ECRELCLNS--PYR 330
            .||..|.          :|.|.|:              ..|.||       .|.:||::|  .|.
Frog   313 ICVSSPGSYSCACRAGYQLNEDKK--------------TCSMIDLCSQGNHGCEQLCISSLGSYT 363

  Fly   331 C---HSYDYND---TGDMV--CRLSHHSRATLADVQEPFLEVPEASTYELTSCYNVTIE---CGG 384
            |   ..|..|:   |..|:  |...:||      .|...:.:...........|.:..:   |..
Frog   364 CACRSGYQLNNDKKTCSMIDYCSYGNHS------CQHECVSILNGYYCRCNEGYTLQADGKTCVA 422

  Fly   385 GDMLARIRTSKLFN-----GKVYA--------KGSPKSCS------VDVKSALD---------FE 421
            .||...:.....|.     |..|.        :...|:|:      :|:...:|         ||
Frog   423 DDMCNIVDHGCEFKCVSTPGSYYCICPEGQELQADGKTCNKCSTGYIDLVFVIDGSKSVRPQNFE 487

  Fly   422 LRMNYHDLECNVRQSTA----GRYVNDIIIQHHDMIVTSSDLGLALACQYDLTNKSVSNGVDLD- 481
            |   ..:...|:..|:|    |.::.  ::|:...:.|...|.     ||       :||.|:.
Frog   488 L---VKEFVINIVDSSAISAQGTHIG--LVQYSSRVRTEFPLS-----QY-------TNGQDIKT 535

  Fly   482 -------VRGDIMPALSEEVIVES------------PNVIMRIT-SRDGSDMMRSAEVGDPLALK 526
                   :....|..|:.:.:||.            |.:.:..| .|...|:...|:......:.
Frog   536 AVKNIQYMEKGTMTGLALKHMVEQSFSEAEGARKNVPKIGLVFTDGRSQDDISEWAKKAKEAGIT 600

  Fly   527 FEIVDEQSPYEIFIRELVAMDGV--------DNSEITLIDS----NGCPTDHFIMGPIYKGSVSG 579
            ...|......|..:.| :|.|.|        |.|.:.||..    |.||.:       .||:...
Frog   601 MYAVGVGKAVEDELNE-IASDPVNKHSFYTADFSTMNLIAEDLKLNICPEE-------IKGTTET 657

  Fly   580 KMLLSNFDAFKFPSSEVVQFRALVTPCMPSCEPVQCEQEDTSGEFRSL 627
            |                       .||  .||.:...|..|..:..||
Frog   658 K-----------------------NPC--DCEHLVSFQTSTIAKLESL 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453	11/77 (14%)
		PAN_AP_HGF	211..285	CDD:238532	19/84 (23%)
		PAN_1	294..373	CDD:278453	19/95 (20%)
		ZP	381..615	CDD:214579	54/301 (18%)
matn4	XP_002938060.3	vWFA	33..255	CDD:412136	34/187 (18%)
		FXa_inhibition	262..297	CDD:405372	8/36 (22%)
		FXa_inhibition	303..338	CDD:405372	8/48 (17%)
		FXa_inhibition	344..379	CDD:405372	8/34 (24%)
		FXa_inhibition	385..420	CDD:405372	5/40 (13%)
		vWFA	<412..460	CDD:412136	6/47 (13%)
		vWFA	467..699	CDD:412136	50/264 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X161
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000