DRSC/TRiP Functional Genomics Resources

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Protein Alignment ca and NEK9

DIOPT Version :9

Sequence 1:NP_001287593.1 Gene:ca / 43518 FlyBaseID:FBgn0000247 Length:1961 Species:Drosophila melanogaster
Sequence 2:NP_001316166.1 Gene:NEK9 / 91754 HGNCID:18591 Length:991 Species:Homo sapiens


Alignment Length:828 Identity:167/828 - (20%)
Similarity:291/828 - (35%) Gaps:245/828 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   845 RYLGHPLLKGILGDIT-YRHSEDVRVI---------LPEKHEEEDVNSGV---------FCSDYH 890
            |.||    :|..|:.| ||.:||..::         |.||...:.:|..|         ..:.|:
Human    56 RVLG----RGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYN 116

  Fly   891 YGVDESISALQMSPSSQFHLANLLLITLAEKAVNDKNY---IPLWNFLVTNSKYHTNMTSIVLCQ 952
            :.:|.:...:::...:..:|.:.:|      ...||.:   :.:|        |...:.|.|.| 
Human   117 HFMDNTTLLIELEYCNGGNLYDKIL------RQKDKLFEEEMVVW--------YLFQIVSAVSC- 166

  Fly   953 SGLFSSAIILAKIRGVCLDTFNALIS----VVAQEFGWYNELNVCLYNLSENIFLETITYLPHVS 1013
              :..:.|:...|:     |.|..::    :...::|...:||      ||....||:...|:  
Human   167 --IHKAGILHRDIK-----TLNIFLTKANLIKLGDYGLAKKLN------SEYSMAETLVGTPY-- 216

  Fly  1014 MDYFA--FIQEKLHHIRP------CV------LQRLSKQLNPFSPALRPIVSHNSDCAMSNDNNP 1064
              |.:  ..|...::.:.      ||      |:|.....||.:..::.:....   ||..|:: 
Human   217 --YMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIR---AMEVDSS- 275

  Fly  1065 QLFEFCKSLIETYLAVLIHMESQRVKYDSIVN--ALSNFRINYEDNQFAIESSRFKPISAGC--A 1125
               ::...||:...:.|.....||...|.:::  .|...|...|:....:.:...:|.|:..  |
Human   276 ---QYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEA 337

  Fly  1126 YCACVVDGTA--YFWGSSGIPSYYSAQKSTEPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLIL 1188
            ..|.|...|:  |.||..         |||  |:....:||       ......:..|..|..::
Human   338 PIAVVTSRTSEVYVWGGG---------KST--PQKLDVIKS-------GCSARQVCAGNTHFAVV 384

  Fly  1189 T-NNGLYSLGNNNLCQLGIGRHMQMA-------LQPMLVTALDGMNITMLEAGQYHNAAVAD-GK 1244
            | ...||:..|   .|.|...|.|:.       .||..|..|.|..|..:..|......|.| |:
Human   385 TVEKELYTWVN---MQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQ 446

  Fly  1245 LYMWGWGIYGQLGQGSCENIATPQL-----VSFFKFKKILQISLGHAHTLVLCGAPNSHMEANHC 1304
            ||.:|...||.:|   .:.:|.|::     ::||....:.|:|.|..|.:||..           
Human   447 LYAFGSDYYGCMG---VDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTR----------- 497

  Fly  1305 GNELFVFGSNHFGQLGTGNSDHGDTKTNLPVRLEVGDCSLRLIHTKFFT-NLAVDEQDRLFTWGS 1368
            ..|::.:|.   |:.|.|:                      |:...||| .|.:|.::..:|   
Human   498 NKEVYSWGC---GEYGRGS----------------------LVSVHFFTGRLGLDSEEDYYT--- 534

  Fly  1369 SPQALRLANQIKRRANAKQKMEENQQRELLSKQ--LEATLLPAPIPSTSTLVEPTTSYAAVVAGS 1431
                             .||::..:...:::.|  .:.|.|             .|....|:|..
Human   535 -----------------PQKVDVPKALIIVAVQCGCDGTFL-------------LTQSGKVLACG 569

  Fly  1432 TPKSSVSDTKDCQD--VQNEA---APSDATETIAPASAKAAPPPVPVASPPVLVPEPDPTEHLTP 1491
            ..:.:......|..  :.:||   .|...:.|:|                          :.|:.
Human   570 LNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLA--------------------------KQLSF 608

  Fly  1492 HLVDTSEVAGRILQISSGLFHFCLISSSCTLYTWGKNLEHQLGTED-KDRRAV-LKPSPIDSIER 1554
            :.:.|         |:.|..|...|.....|.|:|.|...|||..: |.|..: |...|:.. ::
Human   609 YKIRT---------IAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGG-KQ 663

  Fly  1555 PMYVDCGSDFTLVMTTDHVVRAFGGNSNGQCGRDLGPSVERMRQRVVC 1602
            .:.|.||.:||:..|.|:.:.|:|...||:..  :.|: ||.....:|
Human   664 VIRVSCGDEFTIAATDDNHIFAWGNGGNGRLA--MTPT-ERPHGSDIC 708

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
caNP_001287593.1 ATS1 1158..1588 CDD:227511 92/453 (20%)
RCC1_2 1175..1200 CDD:290274 6/25 (24%)
RCC1 1193..1240 CDD:278826 14/53 (26%)
RCC1 1242..1291 CDD:278826 16/54 (30%)
RCC1_2 1503..1532 CDD:290274 8/28 (29%)
RCC1 1522..1568 CDD:278826 16/47 (34%)
RCC1_2 1558..1584 CDD:290274 10/25 (40%)
NEK9NP_001316166.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 18..43
STKc_Nek9 51..308 CDD:270860 55/294 (19%)
S_TKc 52..308 CDD:214567 55/294 (19%)
RCC1 1 388..444 15/58 (26%)
RCC1 389..441 CDD:278826 14/54 (26%)
RCC1 444..495 CDD:278826 15/53 (28%)
RCC1 2 445..498 17/66 (26%)
RCC1 500..559 CDD:278826 17/116 (15%)
RCC1 4 563..627 14/98 (14%)
RCC1 5 628..680 17/52 (33%)
RCC1 628..676 CDD:278826 16/48 (33%)
RCC1 6 681..738 8/31 (26%)
Interaction with NEK6. /evidence=ECO:0000269|PubMed:19001501 744..903
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 752..795
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 833..853
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 947..991
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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