DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ca and RCCD1

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	NP_001017919.1	Gene:	RCCD1 / 91433	HGNCID:	30457	Length:	376	Species:	Homo sapiens

Alignment Length:	250	Identity:	63/250 - (25%)
Similarity:	100/250 - (40%)	Gaps:	62/250 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1138 WGSSGIPSYYSAQKSTEPPEPAHAVKSLDLLS----------------QLNLQVHAIKCGRQHTL 1186
            |..:.:|   .|:...:|...|.|.: |.||.                ...|:...::.|.:|.|
Human   111 WAQNVVP---EAEGEDDPAGEAQAGR-LPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHAL 171

  Fly  1187 ILTNNG-LYSLGNNNLCQLGIGRHMQMALQPMLVTALDGMNITMLEAGQYHNAAVAD-GKLYMWG 1249
            :|...| ::|.|.....|||.|. ::..|:|.|:.||.|:.:..:.||.:|:..|:: |.:|:||
Human   172 LLDAAGQVFSWGGGRHGQLGHGT-LEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235

  Fly  1250 WGIYGQLG-----------------------------QGSCENIATPQLVSFFKFKKILQISLGH 1285
            |...|||.                             .|..|:.|....::...|..:|.:.:|.
Human   236 WNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGS 300

  Fly  1286 AHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTKTNL--PVRLE 1338
            ......||  :.|........||:.:|...:||||     |.|| |:|  |.|:|
Human   301 DAVKASCG--SRHTAVVTRTGELYTWGWGKYGQLG-----HEDT-TSLDRPRRVE 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	58/229 (25%)
		RCC1_2	1175..1200	CDD:290274	7/25 (28%)
		RCC1	1193..1240	CDD:278826	15/46 (33%)
		RCC1	1242..1291	CDD:278826	14/78 (18%)
		RCC1_2	1503..1532	CDD:290274
		RCC1	1522..1568	CDD:278826
		RCC1_2	1558..1584	CDD:290274
RCCD1	NP_001017919.1	Interaction with KDM8. /evidence=ECO:0000269\|PubMed:24981860	1..169		11/61 (18%)
		ATS1	<156..340	CDD:227511	50/192 (26%)
		RCC1 2	176..227		17/51 (33%)
		RCC1 3	229..317		17/89 (19%)
		RCC1 4	318..371		14/35 (40%)
		RCC1	319..366	CDD:395335	14/34 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143337
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840