DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and HERC1

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	XP_016878188.1	Gene:	HERC1 / 8925	HGNCID:	4867	Length:	4909	Species:	Homo sapiens

Alignment Length:	1287	Identity:	254/1287 - (19%)
Similarity:	435/1287 - (33%)	Gaps:	445/1287 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   796 KKITQALLTYN-KARVKPIRTALKLAMYGHTYALMQLSAMALKSTYLLRSRYLGHPLLKGILGDI 859
            :|.:.|...|. :..:.|:||   :|......||:......|.:.:.||.   |..|...::|.
Human  3780 RKSSGAKCVYQLRGHITPVRT---VAFSSDGLALVSGGLGGLMNIWSLRD---GSVLQTVVIGS- 3837

  Fly   860 TYRHSEDVRVILPEKHEEEDVNSGV-FCSDYHYGVDESISALQMSPSSQFHLANLLLITLAEKAV 923
               .:....|.:||        .|| .||      :.|...|.::.::::..||.:|.|
Human  3838 ---GAIQTTVWIPE--------VGVAACS------NRSKDVLVVNCTAEWAAANHVLAT------ 3879

  Fly   924 NDKNYIPLWNFLVTNSKYHTNMTSIVLCQSGLFSSAIILAKIRGV-------CLDTFNALISVVA 981
                                       |::.|        |.:||       |:..|...:.::.
Human  3880 ---------------------------CRTAL--------KQQGVLGLNMAPCMRAFLERLPMML 3909

  Fly   982 QEFGWYNELNVCLYNLSENIFLETITYLPHVSMDYFAFIQEKLHHIRPCVLQRLSKQLNPFSPAL 1046
            ||...|.:.:|        :..:.:.:.|:  |...|.:...||      |.:|  ..||
Human  3910 QEQYAYEKPHV--------VCGDQLVHSPY--MQCLASLAVGLH------LDQL--LCNP----- 3951

  Fly  1047 RPIVSHNSDC----AMSNDNNPQLFEFCKSLIETYLAV---------LIHMESQRVKYDSIVNAL 1098
             |:..|:.:|    |..|.|.....|...:.|:...|:         ....:.:.|..|.:|..:
Human  3952 -PVPPHHQNCLPDPASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFTVPDLEPVPEDELVFLM 4015

  Fly  1099 SNFR-INYEDNQ-FAIESSRFKPISAGCAYCACVVDGTAYFWGSSGIPSYYSAQKSTEPPEPAHA 1161
            .|.: ||..|.| .:..:||.:....| ..|      ..|.||:........|.::...|..|.:
Human  4016 DNSKWINGMDEQIMSWATSRPEDWHLG-GKC------DVYLWGAGRHGQLAEAGRNVMVPAAAPS 4073

  Fly  1162 VKSLDLLSQLNLQVHAIKCGRQHTLILTNNG-LYSLGNNNLCQLGIGRHMQM-------ALQPML 1218
            ..          |...:.||:..|.::..|| :.:.|..:..:||.|....:       |||..:
Human  4074 FS----------QAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFV 4128

  Fly  1219 VTAL------DGMNITMLEAGQYHNAAVADGKLYMWGWGIYGQLGQGSCENIATPQLVSFFKFKK 1277
            ||.|      ||.::.:.|:|:          ::.||.|.||:||.|:.:....|:.:...:.::
Human  4129 VTQLVTSCGSDGHSMALTESGE----------VFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEE 4183

  Fly  1278 ILQISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTKTNLPVRL----- 1337
            ::|:|.|..|:.|:..           ..:||.||:..:|:||.||:    :...||.|:
Human  4184 VVQMSCGFKHSAVVTS-----------DGKLFTFGNGDYGRLGLGNT----SNKKLPERVTALEG 4233

  Fly  1338 -EVGDCSLRLIHTKFFTNLAVD-EQDRLFTWGSSPQA-LRLANQIKRRANAKQKMEENQQRELLS 1399
             ::|..:..|.||     |||. :...::.:|..... |.|.|...:  ::.||::
Human  4234 YQIGQVACGLNHT-----LAVSADGSMVWAFGDGDYGKLGLGNSTAK--SSPQKID--------- 4282

  Fly  1400 KQLEATLLPAPIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKD------CQDVQNEAAPSDATET 1458
                              |........|..|:  :.||:.|||      .||
Human  4283 ------------------VLCGIGIKKVACGT--QFSVALTKDGHVYTFGQD------------- 4314

  Fly  1459 IAPASAKAAPPPVPVASPPVLVPEPDPTEHLTPHLVDTSEVAGRILQ-ISSGLFHFCLISSSCTL 1522
                             ..:.:||.....|..|..:..  :||.|:: ::.|..|...::|:..:
Human  4315 -----------------RLIGLPEGRARNHNRPQQIPV--LAGVIIEDVAVGAEHTLALASNGDV 4360

  Fly  1523 YTWGKNLEHQLGTEDKDRRAVLKPSPIDSIERPMYVDCGSDFTLVMTTDHVVRAFGGN----SNG 1583
            |.||.|.|.|||....:.  |.:|:.:..::                        |.|    |.|
Human  4361 YAWGSNSEGQLGLGHTNH--VREPTLVTGLQ------------------------GKNVRQISAG 4399

  Fly  1584 QCGRDLGPSVERMRQRVVCLPATKRLVRFESQCVEVPVEINLPRPRIRLDQDPVRYLKVMPPYQP 1648
            :|......:.          |...|     :..|.||:::.||      |..|.:| ..:.....
Human  4400 RCHSAAWTAP----------PVPPR-----APGVSVPLQLGLP------DTVPPQY-GALREVSI 4442

  Fly  1649 HFLQPANISFDQHCSVGTPNYKSSTEHAATGQDSDDMLSS--LENLSQN--DASFSYNA------ 1703
            |.:: |.:....|.                   ||.|.||  |.|||.|  :::..|||
Human  4443 HTVR-ARLRLLYHF-------------------SDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIV 4487

  Fly  1704 -----PVLGDAHSSLDM------------DYTPE-------------EQSYVPLPEQAVGSG--- 1735
                 |:|.....:|.|            :|.|:             :..:|.:..|.|...
Human  4488 QGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASD 4552

  Fly  1736 --MPANA--EQLLGRDDDDG-----STYTQSTEGMGESSLQHL-------RHYIHYCLYAFHGLY 1784
              :|:.|  .:|:|...||.     .|.|:..:.: |:.:..|       ...:.|....|  |:
Human  4553 LRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQEL-ETGIVDLLIPSPNATAEVGYNRDRF--LF 4614

  Fly  1785 NPDKIGECARPHRNEYRIRICMLNFRFVEAFRLCLQSCGSAQRT-----LKLFEYFSKDTGYVPL 1844
            ||   ..|...|         ::.|:|:...      .|.|.||     |.|.....|....|||
Human  4615 NP---SACLDEH---------LMQFKFLGIL------MGVAIRTKKPLDLHLAPLVWKQLCCVPL 4661

  Fly  1845 RRTDLKH--LIY----HLCLH-----FLERKF-DMLECERFFMGDLDYYLLEL-----AYVFYFN 1892
            ...||:.  |:|    :..||     ..|..| :|:..:.|.....|..::.:     :....|:
Human  4662 TLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFS 4726

  Fly  1893 NNNSTLEQNLNQKFKQLIAAADSNQAATSAG---------------QELEQL 1929
            |....:|:.:..:..::    |...||...|               ::|||:
Human  4727 NRKEYVERAIEYRLHEM----DRQVAAVREGMSWIVPVPLLSLLTAKQLEQM 4774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	95/462 (21%)
		RCC1_2	1175..1200	CDD:290274	6/25 (24%)
		RCC1	1193..1240	CDD:278826	14/59 (24%)
		RCC1	1242..1291	CDD:278826	13/48 (27%)
		RCC1_2	1503..1532	CDD:290274	9/29 (31%)
		RCC1	1522..1568	CDD:278826	10/45 (22%)
		RCC1_2	1558..1584	CDD:290274	3/29 (10%)
HERC1	XP_016878188.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143352
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750