DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and HERC2

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	NP_004658.3	Gene:	HERC2 / 8924	HGNCID:	4868	Length:	4834	Species:	Homo sapiens

Alignment Length:	1356	Identity:	251/1356 - (18%)
Similarity:	412/1356 - (30%)	Gaps:	527/1356 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   502 IQNLRSTFLLSALHSNSHSLTVHSIDISLKPLFVYKIPKHTQEILISSNILYGIHYVDLHCRSDS 566
            :|.|....:......:|||:...::|::...:       |...:..::....|..|  |...||:
Human  3303 VQGLEGQKITRVACGSSHSVAWTTVDVATPSV-------HEPVLFQTARDPLGASY--LGVPSDA 3358

  Fly   567 DHFTAASLLDDPLVANTEKENRDADIEKVDQSDVSAQKSDSTSATTTATSSLDQSD------MPS 625
            |...|::.:..   |:..|.||.:..:.:...|.:..|..:.|...||...:...|      ||:
Human  3359 DSSAASNKISG---ASNSKPNRPSLAKILLSLDGNLAKQQALSHILTALQIMYARDAVVGALMPA 3420

  Fly   626 TAINAVSVIS---------SAMAS--------LHTSDEDRFN-NLAQ------------------ 654
            ..|..|...|         |||||        |....|||.: |..|
Human  3421 AMIAPVECPSFSSAAPSDASAMASPMNGEECMLAVDIEDRLSPNPWQEKREIVSSEDAVTPSAVT 3485

  Fly   655 -----------------LGLFRFENETVLHLYQMAQYRNPSAEPETLTKEEKAKAFELKDIHTPM 702
                             ||......||:....:..:.:|.:|.||....:|........|....:
Human  3486 PSAPSASARPFIPVTDDLGAASIIAETMTKTKEDVESQNKAAGPEPQALDEFTSLLIADDTRVVV 3550

  Fly   703 DYIQ-------------------------FYETADVSSEFSLRQME----------------IMQ 726
            |.::                         :.:.||:..|..:.::|                :::
Human  3551 DLLKLSVCSRAGDRGRDVLSAVLSGMGTAYPQVADMLLELCVTELEDVATDSQSGRLSSQPVVVE 3615

  Fly   727 SEFP-----------KI------------------NYDPSYVITNKN------------------ 744
            |..|           ||                  .:||..|:...|
Human  3616 SSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLTVMDGVNRIVSVRSGREWSDWSSEL 3680

  Fly   745 -------------------------VYTIQLKKEPFELFLDAALQNEFNQCRDFCNTFDLSFEQC 784
                                     ||.|.....|.||..|        :|...|.:.||  ..|
Human  3681 RIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGPKELLSD--------RCVLSCPSMDL--VTC 3735

  Fly   785 IEFAGDYLLRRKKITQALLTYNKARVKPIRTALKLAMYGHTYALMQLSAMAL--KSTYLLRSRYL 847
            :.   |:.|.        |..|::.|.  |.|..||      |..||||:|.  :...|.|.|.|
Human  3736 LL---DFRLN--------LASNRSIVP--RLAASLA------ACAQLSALAASHRMWALQRLRKL 3781

  Fly   848 GHPLLKGILGDITYRHSEDVRV--ILPEKHEEEDVNSGVFCSDYHYGVDESISALQMSPSSQFHL 910
                       :|....:.:.:  :|.|.                   |....||..:.|:   |
Human  3782 -----------LTTEFGQSININRLLGEN-------------------DGETRALSFTGSA---L 3813

  Fly   911 ANLLLITLAEKAVNDKNYIPLWNFLVTNSKYHTNMTSIVLCQSGLFSSAIILAKIRGVC---LDT 972
            | .|:..|.|.......|   .:.:|...|.        |..|..|...:.||     |   |||
Human  3814 A-ALVKGLPEALQRQFEY---EDPIVRGGKQ--------LLHSPFFKVLVALA-----CDLELDT 3861

  Fly   973 FNALISVVAQEFGWYNELNVCLYNLSEN--IFLETITYLPHVSMDYFAFIQEKLHHIRPCVLQRL 1035
            ......  ..::.|:..     |.::..  :.|:..|.||.:      |:.|....||.  |...
Human  3862 LPCCAE--THKWAWFRR-----YCMASRVAVALDKRTPLPRL------FLDEVAKKIRE--LMAD 3911

  Fly  1036 SKQLNPFSPALRPIVSHNSDCAMSNDNNPQLFEFCKSLIE-----------------TYLAVLIH 1083
            |:.::         |.|.|......:.:.||.::.....:                 .:...|..
Human  3912 SENMD---------VLHESHDIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGG 3967

  Fly  1084 MESQRVKYDSIVNALSNFR----INYEDNQFAIESSRFKPISAGCAYCACVVDGTAYF--WGSSG 1142
            :|..:||..:...||:..|    |..|...||:                 ..||..|.  :|:.|
Human  3968 IEGAKVKVPTPCEALATLRPVQLIGGEQTLFAV-----------------TADGKLYATGYGAGG 4015

  Fly  1143 IPSYYSAQKSTEPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLILTNNG-LYSLGNNNLCQLGI 1206
            .......:..:.|       ..|:.:..:.::..|:..|.:|.|.|::.| :||.|.....:||.
Human  4016 RLGIGGTESVSTP-------TLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGH 4073

  Fly  1207 GRHMQMALQPMLVTALDGMNITMLEAGQYHNAAV-ADGKLYMWGWGIYGQLGQGSCENIATPQLV 1270
            |...... :|.::.:|.|:.:..:.||..|:|.| |.|.||.||.|.||:||....|:...|:||
Human  4074 GNRSPCD-RPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLV 4137

  Fly  1271 SFFKFKKILQISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHG-------D 1328
            ...:..:::.|:.|......||...:         :.::.:|...:|:||.|.|| |       |
Human  4138 EALQGHRVVDIACGSGDAQTLCLTDD---------DTVWSWGDGDYGKLGRGGSD-GCKVPMKID 4192

  Fly  1329 TKTNL-PVRLEVGDCSLRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEEN 1392
            :.|.| .|::|.|        ::|  ::|:.:...::|||..
Human  4193 SLTGLGVVKVECG--------SQF--SVALTKSGAVYTWGKG----------------------- 4224

  Fly  1393 QQRELLSKQLEATLLPAPIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKDCQDVQNEAAPSDATE 1457
                                          .|..:..||  ...|...:..|.:|.:
Human  4225 ------------------------------DYHRLGHGS--DDHVRRPRQVQGLQGK-------- 4249

  Fly  1458 TIAPASAKAAPPPVPVASPPVLVPEPDPTEHLTPHLVDTSEVAGRILQISSGLFHFCLISSSCTL 1522
                                                        :::.|::|..|....:....:
Human  4250 --------------------------------------------KVIAIATGSLHCVCCTEDGEV 4270

  Fly  1523 YTWGKNLEHQLGTEDKDRRAVLKPSPIDSIE--RPMYVDCGSDFTLVMTTDHVVRAFGGNSNGQC 1585
            ||||.|.|.|||  |....|:.:|..:.:::  :...|.|||..||..:|.....|
Human  4271 YTWGDNDEGQLG--DGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASA--------- 4324

  Fly  1586 GRDLGPSVERMRQRVVCLPATKRLVRFESQCVEVPVEINLPRPRIRLDQDPVRYLK 1641
            |:               |||            :||:|.|      .|.:.|:..|:
Human  4325 GK---------------LPA------------QVPMEYN------HLQEIPIIALR 4347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	89/441 (20%)
		RCC1_2	1175..1200	CDD:290274	9/25 (36%)
		RCC1	1193..1240	CDD:278826	13/46 (28%)
		RCC1	1242..1291	CDD:278826	16/48 (33%)
		RCC1_2	1503..1532	CDD:290274	9/28 (32%)
		RCC1	1522..1568	CDD:278826	18/47 (38%)
		RCC1_2	1558..1584	CDD:290274	8/25 (32%)
HERC2	NP_004658.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..88
		RCC1 1-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	415..461
		RCC1 1-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	462..512
		RCC1 1-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	513..568
		RCC1	514..566	CDD:278826
		RCC1 1-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	569..620
		RCC1	569..620	CDD:278826
		RCC1 1-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	623..674
		RCC1	623..672	CDD:278826
		RCC1 1-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	675..726
		RCC1	675..724	CDD:278826
		RCC1 1-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	728..778
		Cyt-b5	1209..1282	CDD:278597
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1555..1575
		MIB_HERC2	1870..1929	CDD:284184
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1933..1958
		UBA_HERC2	2460..2507	CDD:270585
		Cul7	2554..2631	CDD:288381
		ZZ_HERC2	2706..2750	CDD:239084
		APC10-HERC2	2765..2910	CDD:176485
		RCC1 2-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	2958..3009
		RCC1	2960..3007	CDD:278826
		RCC1 2-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3010..3064
		RCC1	3010..3062	CDD:278826
		RCC1 2-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3065..3116
		RCC1	3065..3114	CDD:278826
		RCC1	3117..3168	CDD:278826
		RCC1 2-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3118..3168
		RCC1 2-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3171..3222
		RCC1	3171..3220	CDD:278826
		RCC1	3223..3272	CDD:278826
		RCC1 2-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3224..3274
		RCC1 2-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3275..3326		5/22 (23%)
		RCC1	3275..3324	CDD:278826	5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3602..3629		2/26 (8%)
		RCC1 3-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3951..4002		11/67 (16%)
		RCC1 3-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4004..4056		11/58 (19%)
		RCC1_2	4039..4069	CDD:290274	9/29 (31%)
		RCC1	4057..4106	CDD:278826	14/49 (29%)
		RCC1 3-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4058..4108		15/50 (30%)
		RCC1 3-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4110..4162		18/51 (35%)
		RCC1	4110..4160	CDD:278826	17/49 (35%)
		RCC1	4163..4212	CDD:278826	15/68 (22%)
		RCC1 3-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4164..4214		16/60 (27%)
		RCC1	4215..4263	CDD:278826	12/154 (8%)
		RCC1 3-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4216..4266		12/156 (8%)
		RCC1	4267..4316	CDD:278826	18/50 (36%)
		RCC1 3-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4268..4318		18/51 (35%)
		HECTc	4421..4792	CDD:238033
		HECTc	4464..4790	CDD:214523
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4804..4834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820