DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and HERC2

DIOPT Version :10

Sequence 1:	NP_733309.3	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	NP_004658.3	Gene:	HERC2 / 8924	HGNCID:	4868	Length:	4834	Species:	Homo sapiens

Alignment Length:	1356	Identity:	251/1356 - (18%)
Similarity:	412/1356 - (30%)	Gaps:	527/1356 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   502 IQNLRSTFLLSALHSNSHSLTVHSIDISLKPLFVYKIPKHTQEILISSNILYGIHYVDLHCRSDS 566
            :|.|....:......:|||:...::|::...:       |...:..::....|..|  |...||:
Human  3303 VQGLEGQKITRVACGSSHSVAWTTVDVATPSV-------HEPVLFQTARDPLGASY--LGVPSDA 3358

  Fly   567 DHFTAASLLDDPLVANTEKENRDADIEKVDQSDVSAQKSDSTSATTTATSSLDQSD------MPS 625
            |...|::.:..   |:..|.||.:..:.:...|.:..|..:.|...||...:...|      ||:
Human  3359 DSSAASNKISG---ASNSKPNRPSLAKILLSLDGNLAKQQALSHILTALQIMYARDAVVGALMPA 3420

  Fly   626 TAINAVSVIS---------SAMAS--------LHTSDEDRFN-NLAQ------------------ 654
            ..|..|...|         |||||        |....|||.: |..|
Human  3421 AMIAPVECPSFSSAAPSDASAMASPMNGEECMLAVDIEDRLSPNPWQEKREIVSSEDAVTPSAVT 3485

  Fly   655 -----------------LGLFRFENETVLHLYQMAQYRNPSAEPETLTKEEKAKAFELKDIHTPM 702
                             ||......||:....:..:.:|.:|.||....:|........|....:
Human  3486 PSAPSASARPFIPVTDDLGAASIIAETMTKTKEDVESQNKAAGPEPQALDEFTSLLIADDTRVVV 3550

  Fly   703 DYIQ-------------------------FYETADVSSEFSLRQME----------------IMQ 726
            |.::                         :.:.||:..|..:.::|                :::
Human  3551 DLLKLSVCSRAGDRGRDVLSAVLSGMGTAYPQVADMLLELCVTELEDVATDSQSGRLSSQPVVVE 3615

  Fly   727 SEFP-----------KI------------------NYDPSYVITNKN------------------ 744
            |..|           ||                  .:||..|:...|
Human  3616 SSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLTVMDGVNRIVSVRSGREWSDWSSEL 3680

  Fly   745 -------------------------VYTIQLKKEPFELFLDAALQNEFNQCRDFCNTFDLSFEQC 784
                                     ||.|.....|.||..|        :|...|.:.||  ..|
Human  3681 RIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGPKELLSD--------RCVLSCPSMDL--VTC 3735

  Fly   785 IEFAGDYLLRRKKITQALLTYNKARVKPIRTALKLAMYGHTYALMQLSAMAL--KSTYLLRSRYL 847
            :.   |:.|.        |..|::.|.  |.|..||      |..||||:|.  :...|.|.|.|
Human  3736 LL---DFRLN--------LASNRSIVP--RLAASLA------ACAQLSALAASHRMWALQRLRKL 3781

  Fly   848 GHPLLKGILGDITYRHSEDVRV--ILPEKHEEEDVNSGVFCSDYHYGVDESISALQMSPSSQFHL 910
                       :|....:.:.:  :|.|.                   |....||..:.|:   |
Human  3782 -----------LTTEFGQSININRLLGEN-------------------DGETRALSFTGSA---L 3813

  Fly   911 ANLLLITLAEKAVNDKNYIPLWNFLVTNSKYHTNMTSIVLCQSGLFSSAIILAKIRGVC---LDT 972
            | .|:..|.|.......|   .:.:|...|.        |..|..|...:.||     |   |||
Human  3814 A-ALVKGLPEALQRQFEY---EDPIVRGGKQ--------LLHSPFFKVLVALA-----CDLELDT 3861

  Fly   973 FNALISVVAQEFGWYNELNVCLYNLSEN--IFLETITYLPHVSMDYFAFIQEKLHHIRPCVLQRL 1035
            ......  ..::.|:..     |.::..  :.|:..|.||.:      |:.|....||.  |...
Human  3862 LPCCAE--THKWAWFRR-----YCMASRVAVALDKRTPLPRL------FLDEVAKKIRE--LMAD 3911

  Fly  1036 SKQLNPFSPALRPIVSHNSDCAMSNDNNPQLFEFCKSLIE-----------------TYLAVLIH 1083
            |:.::         |.|.|......:.:.||.::.....:                 .:...|..
Human  3912 SENMD---------VLHESHDIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGG 3967

  Fly  1084 MESQRVKYDSIVNALSNFR----INYEDNQFAIESSRFKPISAGCAYCACVVDGTAYF--WGSSG 1142
            :|..:||..:...||:..|    |..|...||:                 ..||..|.  :|:.|
Human  3968 IEGAKVKVPTPCEALATLRPVQLIGGEQTLFAV-----------------TADGKLYATGYGAGG 4015

  Fly  1143 IPSYYSAQKSTEPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLILTNNG-LYSLGNNNLCQLGI 1206
            .......:..:.|       ..|:.:..:.::..|:..|.:|.|.|::.| :||.|.....:||.
Human  4016 RLGIGGTESVSTP-------TLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGH 4073

  Fly  1207 GRHMQMALQPMLVTALDGMNITMLEAGQYHNAAV-ADGKLYMWGWGIYGQLGQGSCENIATPQLV 1270
            |...... :|.::.:|.|:.:..:.||..|:|.| |.|.||.||.|.||:||....|:...|:||
Human  4074 GNRSPCD-RPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLV 4137

  Fly  1271 SFFKFKKILQISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHG-------D 1328
            ...:..:::.|:.|......||...:         :.::.:|...:|:||.|.|| |       |
Human  4138 EALQGHRVVDIACGSGDAQTLCLTDD---------DTVWSWGDGDYGKLGRGGSD-GCKVPMKID 4192

  Fly  1329 TKTNL-PVRLEVGDCSLRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEEN 1392
            :.|.| .|::|.|        ::|  ::|:.:...::|||..
Human  4193 SLTGLGVVKVECG--------SQF--SVALTKSGAVYTWGKG----------------------- 4224

  Fly  1393 QQRELLSKQLEATLLPAPIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKDCQDVQNEAAPSDATE 1457
                                          .|..:..||  ...|...:..|.:|.:
Human  4225 ------------------------------DYHRLGHGS--DDHVRRPRQVQGLQGK-------- 4249

  Fly  1458 TIAPASAKAAPPPVPVASPPVLVPEPDPTEHLTPHLVDTSEVAGRILQISSGLFHFCLISSSCTL 1522
                                                        :::.|::|..|....:....:
Human  4250 --------------------------------------------KVIAIATGSLHCVCCTEDGEV 4270

  Fly  1523 YTWGKNLEHQLGTEDKDRRAVLKPSPIDSIE--RPMYVDCGSDFTLVMTTDHVVRAFGGNSNGQC 1585
            ||||.|.|.|||  |....|:.:|..:.:::  :...|.|||..||..:|.....|
Human  4271 YTWGDNDEGQLG--DGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASA--------- 4324

  Fly  1586 GRDLGPSVERMRQRVVCLPATKRLVRFESQCVEVPVEINLPRPRIRLDQDPVRYLK 1641
            |:               |||            :||:|.|      .|.:.|:..|:
Human  4325 GK---------------LPA------------QVPMEYN------HLQEIPIIALR 4347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_733309.3	ATS1	1181..1587	CDD:444065	86/417 (21%)
HERC2	NP_004658.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..88
		RCC1 1-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	415..461
		ATS1	454..775	CDD:444065
		RCC1 1-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	462..512
		RCC1 1-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	513..568
		RCC1 1-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	569..620
		RCC1 1-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	623..674
		RCC1 1-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	675..726
		RCC1 1-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	728..778
		Cyt-b5	1211..1282	CDD:459698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1555..1575
		MIB_HERC2	1870..1930	CDD:461991
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1933..1958
		UBA_HERC2	2460..2507	CDD:270585
		Cul7	2554..2631	CDD:463286
		SH3_15	2639..2696	CDD:465720
		ZZ_HERC2	2706..2750	CDD:239084
		APC10-HERC2	2765..2910	CDD:176485
		ATS1	2948..3301	CDD:444065
		RCC1 2-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	2958..3009
		RCC1 2-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	3010..3064
		RCC1 2-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	3065..3116
		RCC1 2-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	3118..3168
		RCC1 2-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	3171..3222
		RCC1 2-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	3224..3274
		RCC1 2-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	3275..3326		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3602..3629		2/26 (8%)
		ATS1	3944..4292	CDD:444065	96/501 (19%)
		RCC1 3-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	3951..4002		11/67 (16%)
		RCC1 3-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	4004..4056		11/58 (19%)
		RCC1 3-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	4058..4108		15/50 (30%)
		RCC1 3-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	4110..4162		18/51 (35%)
		RCC1 3-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	4164..4214		16/60 (27%)
		RCC1 3-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	4216..4266		12/156 (8%)
		RCC1 3-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.22	4268..4318		18/51 (35%)
		HECTc	4421..4792	CDD:238033
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4804..4834
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.

DRSC/TRiP Functional Genomics Resources

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and HERC2

DIOPT Version :10

Known Domains:

Indicated by green bases in alignment.