DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and PRAF1

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	NP_565144.1	Gene:	PRAF1 / 844030	AraportID:	AT1G76950	Length:	1103	Species:	Arabidopsis thaliana

Alignment Length:	773	Identity:	172/773 - (22%)
Similarity:	261/773 - (33%)	Gaps:	229/773 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1044 PALRPIVSHNSDCAMSNDNNPQLFEFCKSLIETYLAVLIHMESQRVKYDSIVNALSNFRINYEDN 1108
            |.:.|..|..|..|:.|.|                     |:::       |:....||::....
plant   185 PEVPPTDSEKSHVALDNKN---------------------MQTK-------VSGSDGFRVSVSSA 221

  Fly  1109 QFAIESSRFKPISAGCAYCACVVDGTAYFWG--------SSGI---PSYYSAQKSTEPPEPAHAV 1162
            |   .||     |.|.|.......|..|.||        ..||   .||.:.:.....|:|
plant   222 Q---SSS-----SHGSAADDSDALGDVYIWGEVICDNVVKVGIDKNASYLTTRTDVLVPKP---- 274

  Fly  1163 KSLDLLSQLNLQVHAIKCGRQHTLILTNNG-LYSLGNNNLCQL--GIGRHMQMALQPMLVTALDG 1224
                |.|.:.|.||.|.||.:|...:|..| :::.|..:..:|  |||:.:   ..|.||.:|..
plant   275 ----LESNIVLDVHQIACGVRHAAFVTRQGEIFTWGEESGGRLGHGIGKDV---FHPRLVESLTA 332

  Fly  1225 -MNITMLEAGQYHNAAVA-DGKLYMWGWGIY--GQLGQGSCENIATP-QLVSFFKFKKILQISLG 1284
             .::..:..|::|..||. .|:||.||.|.:  |.||.||..:...| ::....:...:..:|.|
plant   333 TSSVDFVACGEFHTCAVTLAGELYTWGDGTHNVGLLGHGSDISHWIPKRIAGSLEGLHVASVSCG 397

  Fly  1285 HAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTKTNLPVRLEVGDCS-LRLI- 1347
            ..||.::...           ..||.||...||.||     |||.:| :....||...| ||.|
plant   398 PWHTALITSY-----------GRLFTFGDGTFGVLG-----HGDKET-VQYPREVESLSGLRTIA 445

  Fly  1348 ------HTKFFTNLAVDEQD-------RLFTWGSSPQALRLANQIKRRANAKQKMEENQQRELLS 1399
                  ||.....:.|.:.:       :|||||...         |.|.....|          .
plant   446 VSCGVWHTAAVVEIIVTQSNSSSVSSGKLFTWGDGD---------KNRLGHGDK----------D 491

  Fly  1400 KQLEATLLPAPIP--------STSTLVEPTTSYAAVVAGSTPKSSVSDTKDCQDVQNEAAPSDAT 1456
            .:|:.|.:||.|.        ..|..|..|||......|||....:.:.:
plant   492 PRLKPTCVPALIDYNFHKIACGHSLTVGLTTSGQVFTMGSTVYGQLGNLQ--------------- 541

  Fly  1457 ETIAPASAKAAPPPVPVASPPVLVPEPDPTEHLTPHLVDTSEVAGRILQISSGLFHFCLISSSCT 1521
                                         |:...|.||:....:..:.:||.|.:|...::|...
plant   542 -----------------------------TDGKLPCLVEDKLASEFVEEISCGAYHVAALTSRNE 577

  Fly  1522 LYTWGKNLEHQLGTEDKDRRAVLKPSPIDSIE--RPMYVDCGSDFTLVMTTDHVVRAFGGNSNGQ 1584
            :|||||....:||..|.:.|.|  |:.:::::  ...|:.|||::|..:.....|   .|....|
plant   578 VYTWGKGANGRLGHGDLEDRKV--PTIVEALKDRHVKYIACGSNYTAAICLHKWV---SGAEQSQ 637

  Fly  1585 CGR-DLGPSVERMRQ-------------------RVVCLPATKRLVRFESQC---VEVPVEIN-- 1624
            |.. .|.....|.|.                   |....|:..||.|....|   :....|||
plant   638 CSTCRLAFGFTRKRHNCYNCGLVHCHSCSSKKAFRAALAPSAGRLYRVCDSCYVKLSKVSEINDT 702

  Fly  1625 ------LPR----PRIRLDQDPVRYLKVMPPYQPHFLQPANISFDQHCSVGTPNYKSSTEHAATG 1679
                  :||    .|.|||:..:|..|         ...:|:...:............|:..:.|
plant   703 NRRNSAVPRLSGENRDRLDKSEIRLAK---------FGTSNMDLIKQLDSKAAKQGKKTDTFSLG 758

  Fly  1680 QDSD--DMLSSLENLSQNDASFSYNAPVLGDAHSSL-DMDYTP------EEQSYVPLP 1728
            ::|.  .:|...:.:..|........|.|..|.|.: ....:|      ..:|..|:|
plant   759 RNSQLPSLLQLKDAVQSNIGDMRRATPKLAQAPSGISSRSVSPFSRRSSPPRSATPMP 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	112/463 (24%)
		RCC1_2	1175..1200	CDD:290274	9/25 (36%)
		RCC1	1193..1240	CDD:278826	11/49 (22%)
		RCC1	1242..1291	CDD:278826	16/51 (31%)
		RCC1_2	1503..1532	CDD:290274	10/28 (36%)
		RCC1	1522..1568	CDD:278826	16/47 (34%)
		RCC1_2	1558..1584	CDD:290274	6/25 (24%)
PRAF1	NP_565144.1	PH_PLC_plant-like	14..124	CDD:270171
		ATS1	238..628	CDD:227511	117/482 (24%)
		FYVE	627..695	CDD:214499	13/70 (19%)
		COG1340	<828..909	CDD:224259
		BRX_N	879..>908	CDD:404581
		BRX	1022..1077	CDD:400608
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820