DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and EEA1

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	XP_011537116.1	Gene:	EEA1 / 8411	HGNCID:	3185	Length:	1453	Species:	Homo sapiens

Alignment Length:	1078	Identity:	193/1078 - (17%)
Similarity:	330/1078 - (30%)	Gaps:	382/1078 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 HECPNSKKCPNHSTGLEESTAEPM-----------------DQLAENLE---------------- 163
            |:...:|:.......|::||...:                 ||..:|||
Human   523 HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKE 587

  Fly   164 ----QARLQEGEEEEPLGHDLPEHMLVRNSGTEDAVQPLPQ---------QQQTIDTTGNSQVMA 215
                .|::|.||.|..:.:.|.|    :|...::.|..|.:         :|...:.....|...
Human   588 REDLYAKIQAGEGETAVLNQLQE----KNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQK 648

  Fly   216 ASFMASKTCPYPLSVVWWKTNSGQNRAIIGYSDGSICFVGLSPNCPMIASTAIENGSVMRLVICK 280
            |...|::.....|.....:.||..|.:                                     |
Human   649 AHLRAAQDRVLSLETSVNELNSQLNES-------------------------------------K 676

  Fly   281 DKAYDGVMLLITSSLKQQYKLLLEQKAIKYVYPGD--SSPTTREGAWQIVMSVQDKHQ------- 336
            :|...     :...:|.:.:|||..:|.|.....|  :...|.:.|      :|||.|
Human   677 EKVSQ-----LDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA------LQDKQQELNKITT 730

  Fly   337 -----SAATGARQSNSSDPASDSSQLEEDVFAPPSSDDVVCSGPGAANSDPSTVSASAEAATADV 396
                 :|....:|.:.|...|...:.:|...:.....:.:........:|...|.||.|.|..|:
Human   731 QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDL 795

  Fly   397 PPPPAPPSYSEAVARQSGDQGGVRFQQQQLPAGSMDGILPATR--------------ARLASLKS 447
            .                        ||:||   :.|..|.||.              .||...|.
Human   796 Q------------------------QQRQL---NTDLELRATELSKQLEMEKEIVSSTRLDLQKK 833

  Fly   448 LGSKKLQAIKMRLSDQ-------RQKFDEFMPDS---------------------TMGSFAIMDS 484
              |:.|::||.:|:.|       :|.|:....::                     .|...|:|..
Human   834 --SEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTE 896

  Fly   485 PSVTPEPLGTTSGSFYNIQNLRSTF-------------LLSALHSNSHSLTV------------- 523
            .|...:.|...|.|   ::|.:|.|             |........|.|.|
Human   897 LSTVKDKLSKVSDS---LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK 958

  Fly   524 ----------HSIDISLKPLFVYKIPKHTQEILI-SSNILYGIHYVDLHCRSDSDHFTAAS---- 573
                      |.:.:.|..:         ||.|| :.|.|......:...:.:.:....:|
Human   959 KSLEKEKEASHQLKLELNSM---------QEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKK 1014

  Fly   574 --------LLDDPLVANTEKENR------------DADIEKVDQSDVSAQKSDSTSATTTATSSL 618
                    .|...::..||.||:            .|:.||:.....:.:||..|.....:....
Human  1015 KQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYG 1079

  Fly   619 DQSDMPSTAINAVSVISSAMASLHTSDEDRFNNLAQLGLFRFENETVLHLYQMAQYRNPSAEPET 683
            .:|::.:|..:    :.|....|..:.||..:|..|:|     |:.  .|.|..:....:.|.::
Human  1080 RESELLATRQD----LKSVEEKLSLAQEDLISNRNQIG-----NQN--KLIQELKTAKATLEQDS 1133

  Fly   684 LTKE----EKAKAFELKDIHTPMDYIQFYETADVSSEFSLRQMEIMQ-----SEFPKINYDPSYV 739
            ..||    |:.||.:                 |:..|.||::.|::.     :|..:|.......
Human  1134 AKKEQQLQERCKALQ-----------------DIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKE 1181

  Fly   740 ITNKNVYTIQLKKEPFELFLDAALQNEFNQCRDFCNTFDLSFEQCIEFAG--DYL---LRRKKIT 799
            ||..|.   :||....|..      .|....:|   ...|..:|.:|..|  |.|   :.::|..
Human  1182 ITKLNE---ELKSHKLESI------KEITNLKD---AKQLLIQQKLELQGKADSLKAAVEQEKRN 1234

  Fly   800 QALLTYNKARVKPIRTALK------------------LAMYGH----TYALMQLSAM-----ALK 837
            |.:|   |.:||.....||                  :.|..|    ....||::|:     .:|
Human  1235 QQIL---KDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVK 1296

  Fly   838 STYLLRSRYLGH-----PLLKGILG--DITYRHSEDVRVILPEK-----HEEEDVNSGVFCSDYH 890
            ..:....|.:..     ..|:|.:.  :.|.::::|.|..|.|:     .|.|.:.:.|.  :..
Human  1297 KEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVL--ELQ 1359

  Fly   891 YGVDESISALQMSPSSQFHLANLLLITLAEKAVNDKNYIPLW--------------NFLVTNSKY 941
            ..:|.:.:|:|     :....|..|.....:|:|.|     |              .|.||..::
Human  1360 RKLDNTTAAVQ-----ELGRENQSLQIKHTQALNRK-----WAEDNEVQNCMACGKGFSVTVRRH 1414

  Fly   942 HTNMTSIVLCQSGLFSSAIILAK---IRGVCLDTFNAL 976
            |......:.|......:|:..:.   :| ||...||.|
Human  1415 HCRQCGNIFCAECSAKNALTPSSKKPVR-VCDACFNDL 1451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511
		RCC1_2	1175..1200	CDD:290274
		RCC1	1193..1240	CDD:278826
		RCC1	1242..1291	CDD:278826
		RCC1_2	1503..1532	CDD:290274
		RCC1	1522..1568	CDD:278826
		RCC1_2	1558..1584	CDD:290274
EEA1	XP_011537116.1	Myosin_tail_1	308..1382	CDD:279860	177/1001 (18%)
		DUF342	<425..519	CDD:302792
		FYVE_EEA1	1389..1451	CDD:277269	13/67 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900