DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and AT5G12350

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	NP_568268.3	Gene:	AT5G12350 / 831110	AraportID:	AT5G12350	Length:	1075	Species:	Arabidopsis thaliana

Alignment Length:	759	Identity:	164/759 - (21%)
Similarity:	270/759 - (35%)	Gaps:	235/759 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   983 EFGWYNELNVCLYNLSENIFLETITYLPHVSMDYFAFIQE---KLHHI-------RPCVLQRL-- 1035
            ::|...:...|.:.||.:   ||:       :.:|:..:|   ||.|:       |..:.||.
plant    36 KYGRRGKPKFCPFRLSND---ETV-------LIWFSGNEEKHLKLSHVSRIISGQRTPIFQRYPR 90

  Fly  1036 -SKQLNPFS----------------------PALRPIVSH----------NSDCAMSNDNNPQLF 1067
             .|:...||                      ..|:.::||          .||...|..|:|:.:
plant    91 PEKEYQSFSLIYSERSLDVICKDKDEAEVWFTGLKALISHCHQRNRRTESRSDGTPSEANSPRTY 155

  Fly  1068 EFCKSLIETYLA------------VLIHMESQRVKYDSIVNALSNFRINYEDNQFAIESSRFKPI 1120
            ....|.:.:..:            :.||...:....:.:..|.|:..:      :|:....|.|.
plant   156 TRRSSPLHSPFSSNDSLQKDGSNHLRIHSPFESPPKNGLDKAFSDMAL------YAVPPKGFYPS 214

  Fly  1121 SA------------------GCAYCACVV----------------DGTA----YFW--------- 1138
            .:                  |....|..|                ||.|    :.|
plant   215 DSATISVHSGGSDSMHGHMRGMGMDAFRVSMSSAVSSSSHGSGHDDGDALGDVFIWGEGIGEGVL 279

  Fly  1139 --GSSGIPSYYSAQKSTEPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLILTNNG-LYSLGNNN 1200
              |:..:.|.:..:..:..|      |:|:  |.:.|.|..|.||.||.:::|..| .:|.|..:
plant   280 GGGNRRVGSSFDIKMDSLLP------KALE--STIVLDVQNIACGGQHAVLVTKQGESFSWGEES 336

  Fly  1201 LCQLGIGRHMQMALQPMLVTALDGMNITMLEAGQYHNAAVA-DGKLYMWGWGIYGQLGQGSCENI 1264
            ..:||.|....:. ||.|:.||:..||.::..|::|:.||. .|.||.||.|.:|.||.|:..:.
plant   337 EGRLGHGVDSNIQ-QPKLIDALNTTNIELVACGEFHSCAVTLSGDLYTWGKGDFGVLGHGNEVSH 400

  Fly  1265 ATPQLVSF-FKFKKILQISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGD 1328
            ..|:.|:| .:...:..|:.|..||.|:..|           .:||.||...||.||     |||
plant   401 WVPKRVNFLLEGIHVSSIACGPYHTAVVTSA-----------GQLFTFGDGTFGVLG-----HGD 449

  Fly  1329 TKTNLPVRLEVGDC-SLRLI-------HTKFFTNLAVDEQD-------RLFTWGSSPQALRLANQ 1378
            .|:....| ||... .||.:       ||.....:.|....       :|||||...:. ||.:.
plant   450 KKSVFIPR-EVDSLKGLRTVRAACGVWHTAAVVEVMVGSSSSSNCSSGKLFTWGDGDKG-RLGHG 512

  Fly  1379 IKRRANAKQKMEENQQRELLSKQLEATLLPAPIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKDC 1443
            .|                      |..|:|..:   :.||||  ::..|..|.:...:::.:
plant   513 NK----------------------EPKLVPTCV---AALVEP--NFCQVACGHSLTVALTTS--- 547

  Fly  1444 QDVQNEAAPSDATETIAPASAKAAPPPVPVASPPVLVPEPDPTEHLTPHLVDTSEVAGRILQISS 1508
            ..|....:|.......:.|..|                        ||:.|:.......:.:|:.
plant   548 GHVYTMGSPVYGQLGNSHADGK------------------------TPNRVEGKLHKSFVEEIAC 588

  Fly  1509 GLFHFCLISSSCTLYTWGKNLEHQLGTEDKDRRAVLKPSPIDSI--ERPMYVDCGSDFTLVMTTD 1571
            |.:|..:::|...:|||||....:||..|.|.|.  .|:.::|:  ::...:.||::||..:.
plant   589 GAYHVAVLTSRTEVYTWGKGSNGRLGHGDVDDRN--SPTLVESLKDKQVKSIACGTNFTAAVC-- 649

  Fly  1572 HVVRAFGGNSNGQCGRDLGP-SVERMRQR------VVCLPATKR 1608
             :.|...|.....|.....| |.:|.|..      |.|...|.:
plant   650 -IHRWASGMDQSMCSGCRQPFSFKRKRHNCYNCGLVFCHSCTSK 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	114/449 (25%)
		RCC1_2	1175..1200	CDD:290274	10/25 (40%)
		RCC1	1193..1240	CDD:278826	14/46 (30%)
		RCC1	1242..1291	CDD:278826	17/49 (35%)
		RCC1_2	1503..1532	CDD:290274	9/28 (32%)
		RCC1	1522..1568	CDD:278826	16/47 (34%)
		RCC1_2	1558..1584	CDD:290274	6/25 (24%)
AT5G12350	NP_568268.3	PH_PLC_plant-like	19..129	CDD:270171	18/102 (18%)
		RCC1_2	310..339	CDD:290274	10/28 (36%)
		RCC1	327..375	CDD:278826	15/48 (31%)
		RCC1	378..428	CDD:278826	17/49 (35%)
		RCC1	432..480	CDD:278826	19/53 (36%)
		RCC1	496..544	CDD:278826	17/75 (23%)
		RCC1	547..596	CDD:278826	10/75 (13%)
		RCC1	601..648	CDD:278826	16/48 (33%)
		FYVE	652..719	CDD:279674	10/41 (24%)
		BRX_N	911..946	CDD:290432
		BRX	1006..1060	CDD:285568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820