DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and herc5.2

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	XP_005160175.1	Gene:	herc5.2 / 794323	ZFINID:	ZDB-GENE-090311-16	Length:	987	Species:	Danio rerio

Alignment Length:	726	Identity:	157/726 - (21%)
Similarity:	246/726 - (33%)	Gaps:	199/726 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1098 LSNFRINYED-------NQFAIESSRFKPISAGCAYCACVVDGTAYFWGSSGIPSYYSAQKSTEP 1155
            :|..|:..||       .|..::..:.:.|..|......:.||     |...:...|:.
Zfish    55 VSVLRLRDEDCNQDGKLKQLDLKREKIRSIVCGEDGAVLLADG-----GKVLLMDKYTV------ 108

  Fly  1156 PEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLILTNNG-LYSLGNNNLCQLGIGRHMQMALQPMLV 1219
               ...:|.||     |.:|..|.||.||::.|:|:| |:..|.|...|||:.:...:...|..:
Zfish   109 ---CRPLKGLD-----NTKVIQIACGDQHSVALSNDGQLFVWGENAHGQLGLRKEQALIQSPQHL 165

  Fly  1220 TALDGMNITMLEAGQYHNAAVA-DGKLYMWGWGIYGQLGQGSCENIATPQLVSFFKFKKILQISL 1283
            .:|.|:.:..:.||..|:..:: .|.::.||....||||.|...:...|.:|.....||.:.||.
Zfish   166 QSLCGIPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTTDRFVPTIVKSLSGKKTVSISC 230

  Fly  1284 GHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTKTNLPVRL-------EVGD 1341
            |..||..|..           |..:|.|||..|||||     |...|.....||       :|..
Zfish   231 GGEHTATLSK-----------GGTVFTFGSGGFGQLG-----HNSLKDEHHPRLVAELWGSKVSQ 279

  Fly  1342 CSLRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLAN--QIKRR----------ANAKQKME---- 1390
            .:....||.....|.    :|::::|...|. :|.|  |:|:.          .|.:..||
Zfish   280 VTCGRHHTLVLVALT----NRIYSFGCGMQG-QLGNGEQVKQSVPLPVLLPTDCNCEFTMEKIIA 339

  Fly  1391 -ENQQRELLSK-----------QLEATLLPA-------------PIPSTSTLVEPTTSYAAVVAG 1430
             |.....|..|           .:...:|..             |.|:....::...|.|..:.|
Zfish   340 GEKHSFALFFKNPGNESTKPKSSMNGGILTLNDRMIDRWVSGSYPWPTVKKEIKKVFSSAVCLNG 404

  Fly  1431 STPKSSVSDTKDCQD-----------VQNEAAPSDATETIAPASAKAAPPPVPVASPPVLVPEPD 1484
            |..|.|:    |.||           ..||...|:..:.|.....            |.|.|:|.
Zfish   405 SFLKPSL----DEQDFDLVGKSFSKLTDNEKVISEVVKVIQQTLL------------PSLNPKPA 453

  Fly  1485 PTEH-----LTPHLVDTSE----------VAGRILQISSGLFHFCLISSSCTLYTWGKNLEHQLG 1534
            ..|.     |.|.|:...|          :|.:|||::|.......:..|.....|.|:|.....
Zfish   454 HEESLRLYLLLPELIKGLEQYQRSELNKALASKILQLNSAAREMLEMFWSKLPDDWLKSLVKLFH 518

  Fly  1535 TEDKDRRAVLKPSPIDS----------IERPMYVDCGSDFTLVMTTDHVVRAFGGNSNGQCG--- 1586
            .|..|....:....:||          |.:..|..|.|....:..:|.::.......|....
Zfish   519 KESADLIDYMSVCAMDSDLKHLQNLLRILQMAYKVCCSTHRDITISDFIIYEISDLLNALQATID 583

  Fly  1587 --RDLGPSVE---RMRQRVVCLPATKRLVRF-------ESQCVEVPVEINLPRPRIRLDQDPVRY 1639
              .|..|.|:   .|:.|...:...:.||:|       ..:.:...:||.:.|      :...|:
Zfish   584 DLADWDPFVDYVYMMKLRDYFIKTLEILVKFPFVADYASKRGIFNHLEIKMIR------RSSNRF 642

  Fly  1640 LKVMPPYQPHFLQPANISFDQHCSVGTPNYKSSTEHAATGQDSDDMLSSLENLSQNDASFSYNAP 1704
            |             .|.:|    :|...|.:|.            ::.:|:.|.||..|||:.:.
Zfish   643 L-------------GNATF----NVLHINRESL------------LMDTLKYLRQNTHSFSHLSR 678

  Fly  1705 VLGDAHSSLDM 1715
            |.......:||
Zfish   679 VAFIGEDGIDM 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	118/520 (23%)
		RCC1_2	1175..1200	CDD:290274	11/25 (44%)
		RCC1	1193..1240	CDD:278826	12/46 (26%)
		RCC1	1242..1291	CDD:278826	17/48 (35%)
		RCC1_2	1503..1532	CDD:290274	8/28 (29%)
		RCC1	1522..1568	CDD:278826	11/55 (20%)
		RCC1_2	1558..1584	CDD:290274	4/25 (16%)
herc5.2	XP_005160175.1	RCC1_2	120..149	CDD:290274	12/28 (43%)
		RCC1	136..186	CDD:278826	13/49 (27%)
		RCC1	189..238	CDD:278826	17/48 (35%)
		RCC1	242..290	CDD:278826	16/52 (31%)
		RCC1	296..347	CDD:278826	11/51 (22%)
		HECTc	649..985	CDD:294058	13/53 (25%)
		HECTc	678..984	CDD:214523	3/12 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010