DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ca and Als2

DIOPT Version :9

Sequence 1:NP_001287593.1 Gene:ca / 43518 FlyBaseID:FBgn0000247 Length:1961 Species:Drosophila melanogaster
Sequence 2:NP_001153420.2 Gene:Als2 / 74018 MGIID:1921268 Length:1651 Species:Mus musculus


Alignment Length:995 Identity:183/995 - (18%)
Similarity:294/995 - (29%) Gaps:403/995 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly  1181 GRQHTLILTNNG-LYSLG-------NNNLCQLGIGRHMQMALQPMLVTALDGMNITMLEAGQYHN 1237
            |.:|.::||.:| :||.|       :..:|          ...|:|.:||.|.::..:..|.:|:
Mouse    49 GVRHGVLLTEDGEVYSFGTLPWKSESAEIC----------PSSPLLESALVGHHVITVATGSFHS 103

  Fly  1238 AAVAD-GKLYMWGWGIYGQLGQGSCENIATPQLVSFFKFK-------KILQISLGHAHTLVL--- 1291
            .||.: |.:||||....||....:.:.:..|..||....:       :|||::.|..|||.|   
Mouse   104 GAVTESGVVYMWGENAAGQCAVANQQYVPEPSPVSISDSETSPSLAVRILQLACGEEHTLALSLS 168

  Fly  1292 ---------------------------------------CGA----------PNSHME-----AN 1302
                                                   |||          |...::     .|
Mouse   169 REIWAWGTGCQLGLITTTFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPPQDLKPVPERCN 233

  Fly  1303 HCGNELF---------VFGSNHFGQLGTGNSDHGDTKTNLPVRLEVGDCSLRLIHTKFFTNLAVD 1358
            .|...|.         :...:|...||...|:....|...|....         |.:     |:|
Mouse   234 QCSQLLITMTDKEDHVIISDSHCCPLGVTLSESQAEKHASPAPSP---------HPE-----ALD 284

  Fly  1359 EQDRLF---------TWGSSP----QALRLANQIKRRANAK------------------QKMEEN 1392
            ||..:|         ..|||.    .|:.....:...|...                  ||:.|:
Mouse   285 EQGEVFENTVVEAELNMGSSQTTSGSAISTQQNVVGTAEVSSARTAPSYPDTHAVTAYLQKLSEH 349

  Fly  1393 QQRE------------LLSKQLEATLLPAPIPSTSTLVEPTTSYAAVV---------AGSTPKSS 1436
            ..||            .|.::....|...|..|||.|.....|.|:.|         ||:.....
Mouse   350 SMRENHEPGEKPPQVQPLVEEAVPDLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKK 414

  Fly  1437 VSD---TKDCQDVQNEAAPSDATETIAPASAKAAPPPVPVASPPVLVPEPDPTEHL----TPHLV 1494
            |.:   |..|     |.|....:.:..|.|.|.            |..|....|.|    :..|:
Mouse   415 VMNFYSTAPC-----ETAAQSGSASTGPESLKD------------LREEQVKQESLQGKKSSSLM 462

  Fly  1495 DTSE-----------VAGRILQIS---------------------SGLFHFCLISSSCTLYTWGK 1527
            |..|           :.|.:.|:|                     ||.....|.|....::||||
Mouse   463 DIREEELEGGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGK 527

  Fly  1528 NLEHQLGTEDKDRRAVLKPSPIDSIE--RPMYVDCGSDFTLVMTTDHVVRAFGGNSNGQCGRDLG 1590
            ..|.|||..|...|  |:|..:..::  ..::::.|...:|.:|....|.::|.|:.||.|....
Mouse   528 GKEGQLGHGDVLPR--LQPLCVKCLDGKEVIHLEAGGSHSLALTAKSQVYSWGSNTFGQLGHSEF 590

  Fly  1591 PSVERMRQRVVCLPATKRLVRFESQCVEVPVEINLPRPRIRLDQDPVRYLKVMPPYQPH------ 1649
            |:            ...||.:..|:.....|...         ||...:|.....:||.      
Mouse   591 PT------------TVPRLSKVSSENGVWSVAAG---------QDYSLFLVDTEDFQPGLYYSGR 634

  Fly  1650 --------------------FLQPANISFDQHCSVGTPNYKSSTEHAATGQDSDDMLSSLENLSQ 1694
                                .|..:.:.:....:.|..:|.:..:....|     .::||..|:.
Mouse   635 QDRAEGDTLPENPSGTKTPVLLSCSKLGYISRVTAGKDSYLALVDKNIMG-----YIASLHELAS 694

  Fly  1695 NDASFSYNAPVLGDAHSSLDMDYTPEEQSYVPLPEQAVGSGMPANAEQLL--------------G 1745
            .:..|          :|.|.     |.:|.:..|..::.:.......|||              |
Mouse   695 TERRF----------YSKLS-----EIKSQILRPLLSLENLGTVTTVQLLQEVASRFSKLCYLIG 744

  Fly  1746 RDDDDGSTYTQSTEGMGE-SSLQHLRH-------YIHYCLYAFHGLYNPDKIGECARPHRNEYRI 1802
            :.....|:|.|   ||.| |||..::|       |..||                          
Mouse   745 QHGASLSSYLQ---GMKEASSLVIMKHSSLFLDSYTEYC-------------------------- 780

  Fly  1803 RICMLNFRFVEAFRLCLQSCGSAQRTLKLFEYFSKDTGYVPLRRTDLKHLIYHLCLHFLERKFDM 1867
             ..:.||..:..|:|..:.                                   .:.||.:..::
Mouse   781 -TSVSNFLVMGGFQLLAKP-----------------------------------AIDFLNKNQEL 809

  Fly  1868 LECERFFMGDLDYYLLELAYVFYFNNNNSTLEQNLNQKF-----------KQLIAAADSNQAATS 1921
            |:              :|:.|   |:.|:.|.:.||..|           |.|:..|...:..: 
Mouse   810 LQ--------------DLSEV---NDENTQLMEILNMLFFLPIRRLHNYAKVLLKLATCFEVTS- 856

  Fly  1922 AGQELEQLQDTDVIFDSFTV 1941
              .|.::|||:...::|..:
Mouse   857 --PEYQKLQDSSSCYESLAL 874

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
caNP_001287593.1 ATS1 1158..1588 CDD:227511 120/581 (21%)
RCC1_2 1175..1200 CDD:290274 8/26 (31%)
RCC1 1193..1240 CDD:278826 11/53 (21%)
RCC1 1242..1291 CDD:278826 17/56 (30%)
RCC1_2 1503..1532 CDD:290274 11/49 (22%)
RCC1 1522..1568 CDD:278826 14/47 (30%)
RCC1_2 1558..1584 CDD:290274 6/25 (24%)
Als2NP_001153420.2 RCC1 1. /evidence=ECO:0000305 59..108 14/58 (24%)
RCC1_2 93..122 CDD:290274 9/28 (32%)
RCC1 2. /evidence=ECO:0000305 109..167 18/57 (32%)
RCC1 109..165 CDD:278826 17/55 (31%)
RCC1 3. /evidence=ECO:0000305 169..218 3/48 (6%)
RCC1 170..216 CDD:278826 3/45 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 425..462 9/48 (19%)
RCC1 4. /evidence=ECO:0000305 519..570 14/52 (27%)
RCC1 521..568 CDD:278826 14/48 (29%)
RCC1 5. /evidence=ECO:0000305 572..621 14/69 (20%)
RCC1 573..619 CDD:278826 13/66 (20%)
RhoGEF 689..873 CDD:295373 48/283 (17%)
PH_alsin 899..1004 CDD:241423
PH 920..998 CDD:278594
COG4642 1043..1182 CDD:226989
MORN 1 1043..1065
MORN 1043..1063 CDD:280628
MORN 2 1066..1088
MORN 3 1094..1116
MORN 1094..1114 CDD:280628
MORN 4 1117..1139
MORN 5 1145..1167
COG4642 1166..>1266 CDD:226989
MORN 6 1169..1191
MORN 7 1192..1214
MORN 8 1215..1238
VPS9 1548..1647 CDD:280383
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167833515
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.830

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