Protein Alignment ca and RPGR

DIOPT Version :10

• Sequence 1: NP_733309.3
• Gene: ca / 43518
• FlyBaseID: FBgn0000247
• Length: 1961
• Species: Drosophila melanogaster
• Sequence 2: NP_001030025.1
• Gene: RPGR / 6103
• HGNCID: 10295
• Length: 1152
• Species: Homo sapiens
• Alignment Length: 627
• Identity: 129/627 - (20%)
• Similarity: 223/627 - (35%)
• Gaps: 190/627 - (30%)

  Fly  1230 LEAGQYHNAAV-ADGKLYMWGWGIYGQLGQGSCENIATPQLVSFFKFKKILQISLGHAHTLVLCG 1293
            |..|..|:|.| .:.||||:|...:||||.||...|:.|..|...|.:|:...:.|..||||
Human    40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLV--- 101

  Fly  1294 APNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTKTNLPVRLEVGDCSLRLIHTKFFTNLAVD 1358
                    :..|..::..|.|:.||||.|:::  :..|...:.....:..::.:.....|:.|:.
Human   102 --------STEGGNVYATGGNNEGQLGLGDTE--ERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156

  Fly  1359 EQDRLFTWGSSPQALRLANQIKRRANAKQKMEENQQRELLSKQLEATLLPAPIPSTSTLVEPTTS 1423
            |..|||.||                       :|.:.::..|.:....:|..:    |:.:|.
Human   157 EDGRLFMWG-----------------------DNSEGQIGLKNVSNVCVPQQV----TIGKPV-- 192

  Fly  1424 YAAVVAGSTPKSSVSDTKDCQDVQNEAAPSDATETI--APASAKAAPPPVPVASPPVLVPEPDPT 1486
                       |.:|    |....:....:|....:  .|.:.|...|...:.:
Human   193 -----------SWIS----CGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGN----------- 231

  Fly  1487 EHLTPHLVDTSEVAGRILQISSGLFHFCLISSSCTLYTWGKNLEHQLGT-----EDKDRRAVLKP 1546
             |.||.||  ||:..:::|::.|..|..:::.: .:||:|.....|||.     |..:      |
Human   232 -HRTPQLV--SEIPEKVIQVACGGEHTVVLTEN-AVYTFGLGQFGQLGLGTFLFETSE------P 286

  Fly  1547 SPIDSI--ERPMYVDCGSDFTLVMTTDHVVRAFGGNSNGQCGRDLGPSVERMRQ----------- 1598
            ..|::|  :...|:.||.:.|.::|...::..||...:|:    ||..:|....
Human   287 KVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGK----LGLGLENFTNHFIPTLCSNFL 347

  Fly  1599 ------------RVVCLPATKRLVRFESQCVEV-----PVEINLP-------------------- 1626
                        .:|...|..|.|..|.:..|:     .|...||
Human   348 RFIVKLVACGGCHMVVFAAPHRGVAKEIEFDEINDTCLSVATFLPYSSLTSGNVLQRTLSARMRR 412

  Fly  1627 RPRIRLDQDPVRYLKVMPP----------YQPHFLQPANISFDQHCSVGTPNYKSSTEHAATGQD 1681
            |.|.| ..|.....:.:||          :.|:.:.|       .||     .::..|...:.||
Human   413 RERER-SPDSFSMRRTLPPIEGTLGLSACFLPNSVFP-------RCS-----ERNLQESVLSEQD 464

  Fly  1682 ------SDDMLSSLENLSQNDASFSYNAPVLGDAHSSLDMDY----TPEEQSYVPLPEQAVGSGM 1736
                  .|.:|..:...::.|.|.:..:  ||:....|:|.:    ...|:|....|.|
Human   465 LMQPEEPDYLLDEMTKEAEIDNSSTVES--LGETTDILNMTHIMSLNSNEKSLKLSPVQ------ 521

  Fly  1737 PANAEQLLGR--------DDDDGSTYTQSTE-GMGESSLQHL 1769
            ....:|.:|.        ::||...|.:.:| ..|::..||:
Human   522 KQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHV 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_733309.3	ATS1	1181..1587	CDD:444065	83/366 (23%)
RPGR	NP_001030025.1	ATS1	38..360	CDD:444065	86/401 (21%)