DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and ALS2

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	NP_065970.2	Gene:	ALS2 / 57679	HGNCID:	443	Length:	1657	Species:	Homo sapiens

Alignment Length:	954	Identity:	189/954 - (19%)
Similarity:	310/954 - (32%)	Gaps:	284/954 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1132 DGTAYFWGS----SGIPSYYSAQKSTEPPE--PAHAVKSLDLLSQLNLQVHAIKCGRQHTLILTN 1190
            ||..|.:|:    ||            |.|  |:..:....|:.|   .|..:..|..|:..:|:
Human    59 DGEVYSFGTLPWRSG------------PVEICPSSPILENALVGQ---YVITVATGSFHSGAVTD 108

  Fly  1191 NGL-YSLGNNNLCQLGIGRHMQMALQPMLVTALD-------GMNITMLEAGQYHNAAVADGKLYM 1247
            ||: |..|.|:..|..:. :.|...:|..|:..|       .:.|..|..|:.|..|::..: .:
Human   109 NGVAYMWGENSAGQCAVA-NQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISR-EI 171

  Fly  1248 WGWGIYGQLGQ-GSCENIATPQLVSFFKFKKILQISLGHAHTLVL--CGAPNSHME-----ANHC 1304
            |.||...|||. .:...:..||.|.....:.:||::.|..|:|.|  | .|:..::     .|.|
Human   172 WAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQC-LPSQDLKPVPERCNQC 235

  Fly  1305 GNELF---------VFGSNHFGQLG---TGNSDHGDTKTNLPVRLEVGDCSLRLIHTKFFTN--- 1354
            ...|.         :...:|...||   |.:.......|.|....|..|....:.......|
Human   236 SQLLITMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS 300

  Fly  1355 -----LAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEENQQRELLSKQLEATLL------P 1408
                 .||..|.......||.|.:....:|....|.....:.....|.|.|..:.::.      .
Human   301 VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVREDSEHGE 365

  Fly  1409 APIPSTSTLVE--------PTTSYAAV--------------VAGSTPKSSVSDTKDCQDVQNEAA 1451
            .|:||...|.|        ||||.:|:              ||.:....::|..|    |.|..:
Human   366 KPVPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKK----VMNFYS 426

  Fly  1452 PSDATETIAPASAKAAPPPVPVASPPVLVPEPDPTEHLTPHLVDTSE-----------VAGRILQ 1505
            .:.. ||.|.|.:.|..|.....|....|.:.......:..|||..|           :.|.:.|
Human   427 TTPC-ETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSRRLSLPGLLSQ 490

  Fly  1506 IS---------------------SGLFHFCLISSSCTLYTWGKNLEHQLGTEDKDRRAVLKPSPI 1549
            :|                     ||.....|.|....::||||..|.|||..|...|  |:|..:
Human   491 VSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPR--LQPLCV 553

  Fly  1550 DSIE--RPMYVDCGSDFTLVMTTDHVVRAFGGNSNGQCGRDLGPSVERMRQRVVCLPATKRLVRF 1612
            ..::  ..::::.|...:|.:|....|.::|.|:.||.|....|:            ...||.:.
Human   554 KCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPT------------TVPRLAKI 606

  Fly  1613 ESQ-------------CVEVPVEINLPRPRIRLDQDPVRYLKVMPPYQ----PHFLQPANISFDQ 1660
            .|:             ...|..|...|.......|||.....:...:.    |..|..:.:.:..
Human   607 SSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPVLLSCSKLGYIS 671

  Fly  1661 HCSVGTPNYKSSTEHAATGQDSDDMLSSLENLSQNDASFSYNAPVLGDAHSSL--------DMDY 1717
            ..:.|..:|.:..:....|     .::||..|:..:..| |:.  |.|..|.:        ::..
Human   672 RVTAGKDSYLALVDKNIMG-----YIASLHELATTERRF-YSK--LSDIKSQILRPLLSLENLGT 728

  Fly  1718 TPEEQSYVPLPEQAVGSGMPANAEQLLGRDDDDGSTYTQSTEGMGES-SLQHLRH-------YIH 1774
            |...|..     |.|.|.. :....|:|:   .|::.:....|:.|: ||..|:|       |..
Human   729 TTTVQLL-----QEVASRF-SKLCYLIGQ---HGASLSSFLHGVKEARSLVILKHSSLFLDSYTE 784

  Fly  1775 YCLYAFHGLYNPDKIGECARPHRNEYRIRICMLNFRFVEAFRLCLQSCGSAQRTLKLFEYFSKDT 1839
            ||                           ..:.||..:..|:|..:.
Human   785 YC---------------------------TSITNFLVMGGFQLLAKP------------------ 804

  Fly  1840 GYVPLRRTDLKHLIYHLCLHFLERKFDMLECERFFMGDLDYYLLELAYVFYFNNNNSTLEQNLNQ 1904
                             .:.||.:..::|:              :|:.|   |:.|:.|.:.||.
Human   805 -----------------AIDFLNKNQELLQ--------------DLSEV---NDENTQLMEILNT 835

  Fly  1905 KF-----------KQLIAAADSNQAATSAGQELEQLQDTDVIFD 1937
            .|           |.|:..|...:.|:   .|.::|||:...::
Human   836 LFFLPIRRLHNYAKVLLKLATCFEVAS---PEYQKLQDSSSCYE 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	118/527 (22%)
		RCC1_2	1175..1200	CDD:290274	8/25 (32%)
		RCC1	1193..1240	CDD:278826	12/54 (22%)
		RCC1	1242..1291	CDD:278826	14/49 (29%)
		RCC1_2	1503..1532	CDD:290274	11/49 (22%)
		RCC1	1522..1568	CDD:278826	14/47 (30%)
		RCC1_2	1558..1584	CDD:290274	6/25 (24%)
ALS2	NP_065970.2	RCC1 1. /evidence=ECO:0000305	59..108		14/63 (22%)
		RCC1_2	93..122	CDD:290274	9/28 (32%)
		RCC1 2. /evidence=ECO:0000305	109..167		15/58 (26%)
		RCC1	109..165	CDD:278826	14/56 (25%)
		RCC1 3. /evidence=ECO:0000305	169..218		15/49 (31%)
		RCC1	170..216	CDD:278826	14/45 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	432..480		11/47 (23%)
		RCC1 4. /evidence=ECO:0000305	525..576		14/52 (27%)
		RCC1	527..574	CDD:278826	14/48 (29%)
		RCC1 5. /evidence=ECO:0000305	578..627		10/60 (17%)
		RCC1	579..625	CDD:278826	10/57 (18%)
		RhoGEF	695..879	CDD:295373	47/276 (17%)
		PH_alsin	905..1010	CDD:241423
		PH	926..1004	CDD:278594
		COG4642	1049..1188	CDD:226989
		MORN 1	1049..1071
		MORN	1049..1069	CDD:280628
		MORN 2	1072..1094
		MORN 3	1100..1122
		MORN	1100..1120	CDD:280628
		MORN 4	1123..1145
		MORN 5	1151..1173
		MORN 6	1175..1197
		MORN 7	1198..1220
		MORN 8	1221..1244
		VPS9	1554..1653	CDD:280383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143346
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830