DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and herc2

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	XP_021332870.1	Gene:	herc2 / 558479	ZFINID:	ZDB-GENE-070718-6	Length:	4831	Species:	Danio rerio

Alignment Length:	2441	Identity:	455/2441 - (18%)
Similarity:	736/2441 - (30%)	Gaps:	916/2441 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TNISCKLSAVTAGLDEKRQFLCLVSEENEILLRYISAASGQEVV--KMISW----FRNRVIH-DV 77
            |||...|:.....:|       |:...|.:||         ||.  |:.:|    .||.::. .|
Zfish  1695 TNIGEPLADCLKDVD-------LIPPFNRMLL---------EVTFGKLYAWSIQNVRNILLEASV 1743

  Fly    78 CFDPAGVWLLVL-CFDNTLHIVPALALVDKA-------------HGLSACSLYSTTQV---TSYI 125
            .|...||..:.| ...|.....|:|..:.:|             ||.::.||...:.:   |..:
Zfish  1744 KFKELGVQPVPLQTITNENPAGPSLGTIPQARFLLAMLHMLTLKHGANSLSLLLNSGILALTQSV 1808

  Fly   126 IPFVGPHECPNSKK------CPNHSTGLEESTAE--PMDQLAENLEQARLQE------------- 169
            :..:|| .|.:|::      ....:|.||||..|  |....|...|.|.:.:
Zfish  1809 LRLIGP-SCDSSEEELTSVAHGGSATVLEESRKETAPTPLPASGPELAAMMKISTRVMRGPDWKW 1872

  Fly   170 GEEEEP---LGH---DLPEHMLVR--------NS---GTE-----------DAVQPLPQQQQTID 206
            |:::.|   ||.   :|.|...:|        ||   |.|           .|.||..:...|.|
Zfish  1873 GDQDGPSPGLGRVIGELGEDGWIRVQWDTGSTNSYRMGKEGKYDLKLAEPPPATQPATEDSDTED 1937

  Fly   207 TTGNSQVMAASFMASKTCPYPLSVVWWKT---------NSGQNRAII------------------ 244
            .| ..:||       :.|.:|.:::...|         :||.:..::
Zfish  1938 DT-EGEVM-------EKCAHPTAIMLTSTVNLLKTLSLSSGIHAEVMQVDAVSTLCGLLRILVES 1994

  Fly   245 GYSD---------------------GSICFVGLSPN-CPMIASTAIENGSVMRLVICKDKAYDGV 287
            |.:|                     |.|..:.|.|. |..::|:|..| .::|:|       :|.
Zfish  1995 GANDKTGCSSHKLVSREQHRSWCTLGFIRSIALMPQMCSTLSSSAWIN-LLIRIV-------EGH 2051

  Fly   288 MLLITSSLKQQYKLLLEQKAIKYVYP-----------------------------GDSSPTTREG 323
            ......:|::|   :|..:.::.|.|                             ....|..|||
Zfish  2052 QSFTAITLQRQ---ILALRLLQAVLPSWDKTERSQDMKFLVEKLFGFLGSLLSTCSSDLPLLREG 2113

  Fly   324 AWQIVMSVQDKHQSAATGARQSNSSDPASDSSQLEEDVFAPPSS-----------DDVV---CSG 374
            :   :...:.:.|::.|          |:.||.|.|::.....:           ::.:   .||
Zfish  2114 S---MRRRKSRPQASLT----------ATHSSTLAEEIVTVLRTLHSLSQWNALINEYINSQLSG 2165

  Fly   375 PGAANSDPSTVSA-------SAEAATADVPPPPAPPSYSEAVARQSGDQG----GVRFQQQQLPA 428
            .|...:...|..|       :||||        |..|....:|...|..|    |.|...::...
Zfish  2166 IGDVMAGRHTEVALLEDYLPNAEAA--------AVGSLMAVLAVIGGIDGRLRLGGRVVHEEYGE 2222

  Fly   429 GSMDGILPATRARLASLKSLGSKKLQAIKMRLSDQRQKFDEFMPDSTMGSFAIMDSPSVTP---- 489
            |::..|.|..|.      ::...:::..|:.|..|.:...       |..|::.:.|...|
Zfish  2223 GTVTRITPKGRI------TVQFHEMRNCKVCLLSQLKPLH-------MIPFSVQNLPFAEPMLMV 2274

  Fly   490 -EPLGTTSGSFYNIQNLRSTFLLSALHSNSHSLTVHSIDISL-----KPLFVYKIPK----HTQE 544
             ..|...:||....|.::.        |.|..||...:|:.|     ..|::.|..:    |..:
Zfish  2275 WAQLVNLAGSKLEKQRMKK--------SLSRGLTADQVDVHLLRCQQLRLYILKAARALLSHQDK 2331

  Fly   545 ILISSNILYGIHYVDL-------HCRSDSD-----------------HFTAASLLDDPLVANTEK 585
            :   ..||.....||:       .|.|..|                 ...:||....|:.|...:
Zfish  2332 L---RQILSQAAVVDVSPNPTEDQCASSPDVGDLSPEGPQPPLILLQQLLSASTQPSPIKAIFHR 2393

  Fly   586 ENRDA---------DIEKVDQSDVSAQKSDSTSATTTATSSLDQSDMPSTAINAVSVISSAMASL 641
            :..:|         .:|....|....:.|.|:.|||..|  :.....|....:..|.:..|...|
Zfish  2394 QELEAAALAVCQYLAVESTHPSSPLFEDSSSSEATTPVT--VQHMRPPKQKKHKTSPVPPAPIVL 2456

  Fly   642 HTSDEDRFNNLAQLGLFRFENETVLHLYQMAQYRNPSAEPET------LTKEEKAKAFELKDIHT 700
                     .|.::|..|...|..|.  .::.....|..|..      |.........:|.|..|
Zfish  2457 ---------QLMEMGFQRKNIEFALK--SLSGTTGASGVPGVEALVGWLLDHPDVLITDLSDAET 2510

  Fly   701 PMDYIQFYETADVSSEFSLRQMEIMQSEFPKINYDPSYVITNKNVYTIQLKKEPFELFLDAALQN 765
            ..|        :.|.|..|.::|..:..||   ..|..|:|....:.   |:..|:...|.|:..
Zfish  2511 VSD--------EYSDEEVLEELEEPEPAFP---VPPGVVVTESQTFK---KRSDFQSNDDYAVYV 2561

  Fly   766 EFN-------QCRDFCNTFDLSFE-------------------QC--IEFAGDYLLRRKKITQAL 802
            ..|       :|   |.|::..:|                   ||  .:..|.|.:|  .|...|
Zfish  2562 RENIQVGMMVRC---CRTYEEVYEGDVGKVIKLDRDGLHDLNVQCDWQQKGGTYWVR--YIHTEL 2621

  Fly   803 LTY------------NKARVKPIRTALK---------------------------LAMYGHTYAL 828
            |.:            :|.||||..|..|                           .....|...|
Zfish  2622 LGFPPQSSPSHIKIGDKVRVKPSVTTPKYKWGSVTHRSVGVVKAFSANGKDVIVDFPQQSHWTGL 2686

  Fly   829 MQLSAMAL----------------------------------KSTYLLRSRYLGH---------- 849
              ||.|.|                                  :|.:..|.....|
Zfish  2687 --LSEMELVPSVHPGVRCDGCQMFPINGPRFKCRSCDDFDFCESCFKTRKHNPRHSFGRINEPGQ 2749

  Fly   850 -PLLKGILGDITYRHSEDVRVILPEKHEEEDVNSGVFCSDYHYG--VDESISALQMSPSSQFHLA 911
             |...|..|....||....|.:|.::......|..|..|.....  :|......|.|.|...|..
Zfish  2750 SPTFSGRSGKQLKRHHSSQRGMLIDEWSRVVKNLSVSSSVNQASRLIDCGEQCWQSSGSQGKHWI 2814

  Fly   912 NL-----LLITLAEKAVN--DKNYIPLWNFLVTNSKYHTNMTSIVLCQSGLFSSAIILAKIRGVC 969
            .|     :|:...:..|:  |.:|:|                |:|:...|  :|...|.:::.:.
Zfish  2815 RLELFPDMLVHKLKMIVDPADSSYMP----------------SLVVVSGG--TSLNNLIELKTIN 2861

  Fly   970 LDTFNALISVVAQEFGWYNELNVCLYNLSENIFLETITYLPHVSMDYFAFIQEKLHHIR----PC 1030
            ::..:.::|:          ||.|                    .:|..:|:..:...|    .|
Zfish  2862 INPTDTVVSL----------LNDC--------------------TEYHRYIEVAIKQCRSSGIDC 2896

  Fly  1031 VLQRLSKQLNPFSPALRPIVSHNSDCA----MSNDNNPQLFE---------------FCKSLIET 1076
            .:..||        |:..:.:.:.|.|    :::||..:..|               ...:.|.|
Zfish  2897 KIHGLS--------AVGRVRAEDEDLATVPFLASDNEEEEDEKTATGSMSRKRLSGLESAATIRT 2953

  Fly  1077 YLAV--------LIHMESQRVKYDSIVNALSNFRINYEDNQFAIES-SRFKPISAGCAY-CACVV 1131
            .:.|        |..::..::|..|....||...:    .|.|..| |.|...:.|..| |....
Zfish  2954 KVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNV----VQVAGGSKSLFAVTAEGKVYACGEAT 3014

  Fly  1132 DGTAYFWGSSG---IPSYYSAQKSTEPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLILTNNG- 1192
            :|......|||   ||...||..:       :.||.:           |:..|.:|.:.||.:|
Zfish  3015 NGRLGLGLSSGTIPIPRQISALSN-------YVVKKV-----------AVHSGGRHAMALTVDGK 3061

  Fly  1193 LYSLGNNNLCQLGIGRHMQMALQPMLVTALDGMNITMLEAGQYHNAAV-ADGKLYMWGWGIYGQL 1256
            ::|.|..:..:||....|... :|.|:.||....|..:..|..|:||: :.|:||.||.|.||:|
Zfish  3062 VFSWGEGDDGKLGHFSRMNCD-KPRLIEALKTKRIRDIACGSSHSAAITSSGELYSWGLGEYGRL 3125

  Fly  1257 GQGSCENIATPQLVSFFKFKKILQISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGT 1321
            |.|.......|:||      |:|   |||....|.||:.::...|......:|.:|...||:||.
Zfish  3126 GHGDNTTQLRPKLV------KVL---LGHRVVQVACGSRDAQTLALTDEGMVFSWGDGDFGKLGR 3181

  Fly  1322 GNSDHGDTKTNLPVRLE----VGDCSL-------------------------------------- 1344
            |.|:    ..|:|..:|    .|.|.:
Zfish  3182 GGSE----GCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGTDVHVRKP 3242

  Fly  1345 ---------RLIHTKF--FTNLAVDEQDRLFTWGSSP--QALRLANQIKRRANAKQKME------ 1390
                     :::|...  ...|||.|..::|.||.:.  |.......:.|:....|.:|
Zfish  3243 QMVEGLRGKKIVHVAVGALHCLAVTETGQVFAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITR 3307

  Fly  1391 ----------------------ENQQRELLSKQLEATLLPAPIPSTSTL----------VEPT-- 1421
                                  |....:.....|.|:.|..|..|..:|          |:|.
Zfish  3308 VACGSSHSVAWTTVDVTTPSVHEPVLFQTARDSLGASYLGVPSDSDPSLLSNKLNGVNNVKPNRP 3372

  Fly  1422 ---------------------------TSYA--AVVAG---------STPKSSVSDTKDCQ---- 1444
                                       ..||  |||..         ..|.||.....||.
Zfish  3373 SLAKILLSLDGNLAKQQALSHVLSSLQIMYARDAVVGALMPSCMMPLECPSSSPVPPSDCSSASS 3437

  Fly  1445 --DVQNEAAPSDATE--------------------------TIAPASAKAAPPP-VPVASPP--- 1477
              :.:..|.||::.|                          .:.|::|.|:..| :||...|
Zfish  3438 PCEAEGPALPSESEERVSPHPWMDSKRGEVTTSEDATTPSSAVTPSTASASSRPFIPVTDDPGAA 3502

  Fly  1478 -------------------VLVPEPDPTEHLTPHLV-DTSEVAGRILQIS--------------- 1507
                               .:.|||...:..|..|: |.:.|...:|:::
Zfish  3503 SIIAETMTKTKEDSENQSKAVGPEPQYLDEFTSLLIPDDTRVMVDLLKLAVSLRSGDKGKEVLSA 3567

  Fly  1508 --SGLFHFCLISSSCTLYTWGKNLEHQLGTEDKDRRAVLKPSPIDSIERPMYVDCGSDFTLVMTT 1570
              ||:...|...:...|......|| .:.|:.:..|...:|..::| ..| |:|..|       |
Zfish  3568 VLSGMGTACPQVADMLLELCVTELE-DVATDCQSGRLSSQPVVVES-SHP-YIDDTS-------T 3622

  Fly  1571 DHVVRAFGGNS-----NGQCGRDLGPSVERMRQRVVCLPATKRLVRFES--QCVEVPVEINLPRP 1628
            ...|:..|...     :.||      |.||....:..:....|:|...|  :..:...|:.:|..
Zfish  3623 SGTVKIPGAEGLRVEFDRQC------STERRHDPLTIMDGANRIVSVRSGREWSDWSSELRIPGD 3681

  Fly  1629 RI---------------RLDQDPVRYLKVMPPYQPHFLQPANISFDQHCSVGTPNYKSSTEHAAT 1678
            .:               |....|     :||...|..|      ....|.:..|
Zfish  3682 ELKWKFTSDGSVNGWGWRFTVYP-----IMPAAGPKDL------LSDRCILSCP----------- 3724

  Fly  1679 GQDSDDMLSSLENLSQNDASFSYNAPVLGDAHSSLDMDYTPEEQSYVPLPEQAVGS--------- 1734
               |.|:::.|.:...|   |:.|..::....:||        .:...|...|.|.
Zfish  3725 ---SMDLVTCLLDFRLN---FASNRSIVPRLAASL--------AACAQLSALAAGHRMWALQRLR 3775

  Fly  1735 -------GMPANAEQLLGRDDDDGSTYTQSTEGMGESSL-----QHLRHYIHYCLYAFHG----L 1783
                   |...|..:|||  |.:|...:.|..|...::|     :.|:....|......|    |
Zfish  3776 KLLTTEYGQSININRLLG--DTEGEARSMSFTGSALAALVKGLPEALQRQYEYEEPIVRGGKQLL 3838

  Fly  1784 YNP--------------DKIGECARPHRNEYRIRIC 1805
            ::|              |.:..||..|:..:..|.|
Zfish  3839 HSPFFKVLVALACDLELDTLPCCAETHKWAWFRRYC 3874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	127/642 (20%)
		RCC1_2	1175..1200	CDD:290274	8/25 (32%)
		RCC1	1193..1240	CDD:278826	13/46 (28%)
		RCC1	1242..1291	CDD:278826	19/48 (40%)
		RCC1_2	1503..1532	CDD:290274	7/45 (16%)
		RCC1	1522..1568	CDD:278826	11/45 (24%)
		RCC1_2	1558..1584	CDD:290274	5/30 (17%)
herc2	XP_021332870.1	RCC1	<483..772	CDD:332518
		Cyt-b5	1204..1276	CDD:306642
		MIB_HERC2	1862..1920	CDD:310955	11/57 (19%)
		UBA_HERC2	2453..2499	CDD:270585	9/56 (16%)
		Cul7	2548..2625	CDD:314424	16/81 (20%)
		ZZ_HERC2	2700..2744	CDD:239084	3/43 (7%)
		APC10-HERC2	2759..2902	CDD:176485	31/190 (16%)
		RCC1	2946..3316	CDD:332518	94/405 (23%)
		RCC1	4020..4325	CDD:332518
		HECTc	4418..4789	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910