DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and rpgrb

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	NP_001299605.1	Gene:	rpgrb / 557752	ZFINID:	ZDB-GENE-081015-2	Length:	1413	Species:	Danio rerio

Alignment Length:	847	Identity:	184/847 - (21%)
Similarity:	283/847 - (33%)	Gaps:	320/847 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1120 ISAGCAYCACVVDGTAYF------WGSSGIPSYYSAQKSTEPPEPAHAVKSLDLLSQLNLQVHAI 1178
            ||.|..:.|.|.:....|      ||..|:.:..:..|.|       .||:|.     :.:|...
Zfish    41 ISCGDEHTALVTENGKLFMFGSNNWGQLGLGTKTTVNKPT-------CVKALK-----SERVKLT 93

  Fly  1179 KCGRQHTLILTNNG-LYSLGNNNLCQLGIGR-------HMQMALQPMLVTALDGMN----ITMLE 1231
            .|||.|||:.|:.| ||:.|.||..|||:|.       |:           ::..|    |.||.
Zfish    94 ACGRTHTLVFTSRGNLYACGGNNEGQLGLGDCNDRTSFHL-----------VEFFNKQGPIKMLA 147

  Fly  1232 AGQYHNAAVA-DGKLYMWGWGIYGQLGQGSCENIATPQLVSFFKFKKILQISLGHAHT--LVLCG 1293
            ||...:||:. ||:|||||....||:|.|...|..|||.||.  .|::..:|.|:.|:  :.:.|
Zfish   148 AGSNTSAALTQDGRLYMWGDNSEGQIGLGKESNALTPQEVSV--GKRVFWVSCGYYHSAFVTVDG 210

  Fly  1294 APNSHME-------------ANH-----------------CG---------NELFVFGSNHFGQL 1319
            |..:..|             |||                 ||         ||::.||...||||
Zfish   211 ALYTFGEKDSGKLGLSTEKLANHKVPQQVTDIPDRVVQVACGGGHTVALTENEVYSFGLGQFGQL 275

  Fly  1320 GTGN--------------------------------SDHG-----------------DTKTN--- 1332
            |.|.                                :|:|                 :..||
Zfish   276 GHGTFIFESRLPRVVEHFRKGRVKHAACGENHTALITDNGLLYTFGDGRHGKLGLGEENFTNQFK 340

  Fly  1333 ---LPVRLE-------VGDCSLRLI---HTKFFTNLAVDEQD-------RLFT--WGSSPQALRL 1375
               .|..|:       .|.|.:.::   .|:...:|.::|.|       :.:|  .|.:.....|
Zfish   341 PTLCPRFLDYHVHSVTCGGCHMLVLAKPRTERPDDLILEEDDVTEDYLEKSYTELLGDTHSQTTL 405

  Fly  1376 ANQIKRRANAKQKMEENQQ-----REL--LSKQLEATL-LPAPI-PSTSTLVE-PTTSYAAVVAG 1430
            ...:..|...:::.....|     |.|  ||....|:| :|:.| ||:..|.: |..|.
Zfish   406 NRSLSARVRRRERERSPDQFGQMFRTLPALSGNQSASLSVPSQIRPSSKQLGKIPHNSL------ 464

  Fly  1431 STP---------KSSVSDTKDCQDVQN-----------EAAPSDATETIAPASAKAAPPPVPVAS 1475
            .||         :|||.|::..:|:..           :..|||.|.|::|...|...
Zfish   465 KTPGIRAKSFDDRSSVEDSESVKDLGETTDLLNLTHIMKMDPSDNTLTLSPMEKKKVK------- 522

  Fly  1476 PPVLVPE-----PDPTEHLTPH-----LVDTSEVAGRILQISSGLFHFCLISSSCTLYTWGKNLE 1530
               :|.|     ..|.:..||:     |:....:...:|:.|||        ||....:.|
Zfish   523 ---VVKEHGKEKGKPRDEPTPYSKRAELLSRKALPTELLRSSSG--------SSVVGDSRG---- 572

  Fly  1531 HQLGTEDKD--RRAVLKPSPIDSIERPMYVDCGSDFTLVMTTDHVVRAFGGNSNGQCGRDLGPSV 1593
              |||..|.  ||                   |.|      .::|:.|..|...|.   ..|..:
Zfish   573 --LGTPHKSPKRR-------------------GHD------KENVLIALEGRKPGS---KTGKGM 607

  Fly  1594 ERMRQRVVCLPATKRLVRFESQCVEVPVEINLPRPRIRLDQDPVRYLKVMPPYQPHFLQPANISF 1658
            ::.|      ..:|.|....::.:|              ..|.|:........|       |...
Zfish   608 DKSR------AGSKSLKLKHTELME--------------SSDKVKKQSTEKTQQ-------NQEV 645

  Fly  1659 DQHCSVGTPNYKSSTEHAATGQDSDDML---SSLENLSQNDASFSYNAPVLGDAHSSLDMDYT-- 1718
            :...|.||.  |.:.|.....:..|..|   |.|:|::..:........::.:.|  :|.|.|
Zfish   646 EVQRSKGTS--KPTQEGTGKAKAKDHQLEVKSQLQNVAGKEKGVKSKPIIIVEQH--IDQDLTSK 706

  Fly  1719 --------------------PEEQSYVPLPEQAVGSGMPANAEQLLGRDDDDGSTYTQSTEGMGE 1763
                                .|.:|:||   |:..||...:.:.  .:...:.||.:..|.|...
Zfish   707 NSKEVLPKVQKVKGDTKIAETENKSFVP---QSKKSGSEKDLKS--SKTTKEISTTSHPTSGKDT 766

  Fly  1764 SS 1765
            |:
Zfish   767 SA 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	138/599 (23%)
		RCC1_2	1175..1200	CDD:290274	12/25 (48%)
		RCC1	1193..1240	CDD:278826	17/57 (30%)
		RCC1	1242..1291	CDD:278826	21/50 (42%)
		RCC1_2	1503..1532	CDD:290274	7/28 (25%)
		RCC1	1522..1568	CDD:278826	9/47 (19%)
		RCC1_2	1558..1584	CDD:290274	5/25 (20%)
rpgrb	NP_001299605.1	RCC1	54..102	CDD:278826	15/59 (25%)
		RCC1	107..156	CDD:278826	18/59 (31%)
		RCC1_2	143..172	CDD:290274	14/28 (50%)
		RCC1	159..206	CDD:278826	21/48 (44%)
		RCC1	209..259	CDD:278826	8/49 (16%)
		RCC1	261..311	CDD:278826	10/49 (20%)
		RCC1	314..365	CDD:278826	7/50 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576214
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22870
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940