Protein Alignment ca and als2a

DIOPT Version :10

• Sequence 1: NP_733309.3
• Gene: ca / 43518
• FlyBaseID: FBgn0000247
• Length: 1961
• Species: Drosophila melanogaster
• Sequence 2: XP_021334529.1
• Gene: als2a / 557014
• ZFINID: ZDB-GENE-070402-2
• Length: 1662
• Species: Danio rerio
• Alignment Length: 1015
• Identity: 205/1015 - (20%)
• Similarity: 328/1015 - (32%)
• Gaps: 354/1015 - (34%)

  Fly  1175 VHAIKCGRQHTLILTNNG-LYSLGNNNLCQLGIGRHMQMALQP-----------MLVTALDGMNI 1227
            :|| ..|..|.|:|...| :||.|.                ||           :|.:.|.|.::
Zfish    43 LHA-ALGSLHGLLLIEGGQVYSFGE----------------QPWKPVEPPPASLVLESTLSGQHV 90

  Fly  1228 TMLEAGQYHNAAVA-DGKLYMWGWGIYGQLGQGSCENIATPQLVSFF-------KFKKILQISLG 1284
            ..:.||.||.:||. ||.:.|||...|||.|....:.:.:|..|:..       :..::|.::.|
Zfish    91 ISVSAGSYHCSAVTEDGLVLMWGENSYGQCGVSGTDRVPSPTPVTVVDDETHPPQLVRVLNVACG 155

  Fly  1285 HAHTLVL------------------------------------------CGA------------P 1295
            ..|||.|                                          |||            |
Zfish   156 AQHTLALSNKHEVWAWGSGCQLGLVTNVFPVWKPQKVEHLVGRYVVQIACGAFHSLALVQFLPSP 220

  Fly  1296 NSHMEA-NHCG--NEL----------FVFGSNHFGQLG-----------TGNSDHGDT---KTNL 1333
            ::..:| :.||  |::          .|....|:..||           :|.|....|   |.:.
Zfish   221 DASQQAQDKCGQCNQIRYTMTDKEDHVVISDEHYCPLGVELAESKEGRKSGQSSPAQTPQSKNSS 285

  Fly  1334 PVRLEVGDCSLRLIHTKFF--------TNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKME 1390
            | ..:|..    |..|..|        ||........|...|  |..|       :|:.:....:
Zfish   286 P-NYQVSP----LTSTDTFSSSFQQNTTNQETQPDPSLSETG--PACL-------QRSKSTPYPD 336

  Fly  1391 ENQQRELLSKQLEATLLPAPIPSTSTLVEPTTSYAAVVAGSTP---KSSV-----SDTKDCQDVQ 1447
            |...::.|.|.|:           .||.|..||    ..||.|   :||:     |:..|...::
Zfish   337 EQALKDYLKKILD-----------QTLAEQATS----AGGSHPPSRQSSLTCPFGSEQSDELTLR 386

  Fly  1448 NEAAPSDATETIAPASAKAAPPPVPVASPPVLVPEPDPTEHLTPHLVDTSE-------VAGRI-- 1503
            ..:.....|::|..::.|...     ||..|   .....:|:.|.|..||:       |.|.|
Zfish   387 PSSPALSRTDSITSSARKHIS-----ASDTV---TEQKNQHIIPTLDSTSDDSSQHSSVDGGIYL 443

  Fly  1504 --LQISSG-LFHFC--------------------------------------------------- 1514
              |.||:| ||..|
Zfish   444 SDLVISNGCLFESCEEGGDTAGTDFCPADLLQSKKSISLTDVTLEDTDRNSFSPVSPSDTHRTSN 508

  Fly  1515 -------------LISSSCT-LYTWGKNLEHQLGTEDKDRRAVLKPSPIDSIERP--MYVDCGSD 1563
                         |:.|..| :::|||..|.|||..|...|  |:|..|.|:.:.  :.:..|::
Zfish   509 LRAVRASTSESRNLLPSLFTEVWSWGKGHEGQLGHGDYLPR--LQPLCIKSLSKKEVVKITAGAN 571

  Fly  1564 FTLVMTTDHVVRAFGGNSNGQCGRDLGPSV--------ERMRQRVVCLPATKRLVRFESQCVEVP 1620
            .:|.:|....|.::|....||.||...||.        :.:|...|....|..|:..:..|.: |
Zfish   572 HSLALTAQCQVYSWGSEKFGQLGRMNSPSTVPNLTTVSDGIRVWDVAAGQTHTLLLADGDCYQ-P 635

  Fly  1621 VEINLPRPRIRLDQDPVRYLKVMPPYQPHFLQPANISFDQHCSVGTPNYKSSTEHAATGQDSDDM 1685
            : :.....::..|.|. |.....|...|..:   ||.:......|..|..:..:..|.|     .
Zfish   636 I-LYYSGEQVLEDADS-RTCTQTPTLLPFCM---NIGYVNQVFGGGLNCLALADQNAMG-----F 690

  Fly  1686 LSSLENLSQNDASFSYN---------APVLGDAHSSLDMDYTPEEQSYVPLPEQAVGSGMPANAE 1741
            :|::..|:..:..|..:         :|:|..|..:|.:.    |.|.:...|.|   |..:...
Zfish   691 ISTIHELASAERKFYCSLSKLKNQILSPLLARASLALSLG----ESSMLLFQEMA---GSFSKLC 748

  Fly  1742 QLLGRDDDDGSTYTQSTEGMGESSLQHLRH-------YIHY--------CLYAFHGLYNPDKIGE 1791
            .|.|:.....:.:.|  :|....:|..::|       |..|        .:..|..|..|.:  |
Zfish   749 HLTGQHSVSLTNFLQ--QGKVIETLVLIKHTAIFMDTYKEYSGPVGNFLVMGGFQSLLKPSQ--E 809

  Fly  1792 CARPHRNEYRIRICMLNFRFVEAFRLCLQSCGSAQRTLKLFEYFSKDTGYVPLRRTDLKHLI-YH 1855
            |                  |.:...|......|.::...|::.. .:..|:|     |:||. |:
Zfish   810 C------------------FGKKLELIQALLESKEKNPSLYDLL-VNLFYMP-----LQHLNGYN 850

  Fly  1856 LCLHFLERKFDML--ECERFFMGDLDYYLL-----------ELAYVFYFNNNNSTLEQNLNQKFK 1907
            ..|..|...|::.  |.:|...|...|..|           |..:.|:.|.....||. |.:..:
Zfish   851 RLLLKLANCFEVNTDEYQRIQNGCSKYEALARLVSKQRKDAEATFHFWKNFKGKNLEA-LRKPSR 914

  Fly  1908 QLIAAADSNQAATSAGQELEQLQDTDVIFDSFTVKFKTIL 1947
            :|:..: ||:..|        ||:......|:.:.|..:|
Zfish   915 RLVCES-SNKGLT--------LQNAGRFSASWFILFNDVL 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_733309.3	ATS1	1181..1587	CDD:444065	124/601 (21%)
als2a	XP_021334529.1	ATS1	<46..213	CDD:444065	39/182 (21%)
		ATS1	530..>631	CDD:444065	28/102 (27%)
		PH_alsin	907..1018	CDD:241423	11/49 (22%)
		COG4642	<1055..1212	CDD:443680
		VPS9	1559..1657	CDD:460489