Protein Alignment ca and HERC5

DIOPT Version :9

• Sequence 1: NP_001287593.1
• Gene: ca / 43518
• FlyBaseID: FBgn0000247
• Length: 1961
• Species: Drosophila melanogaster
• Sequence 2: XP_011530324.2
• Gene: HERC5 / 51191
• HGNCID: 24368
• Length: 1100
• Species: Homo sapiens
• Alignment Length: 822
• Identity: 173/822 - (21%)
• Similarity: 295/822 - (35%)
• Gaps: 218/822 - (26%)

  Fly  1082 IHMESQRVKYDSIVNALSNFRINYEDNQFAIESSRF-------KPISAGCA-YCACVVD--GTAY 1136
            ||...|..::..|   ||:....:|.:.::::..||       |.|...|. |.:..:.  |..:
Human   250 IHSVDQGAEHMLI---LSSDGKPFEYDNYSMKHLRFESILQEKKIIQITCGDYHSLALSKGGELF 311

  Fly  1137 FWGSS-----GIPSYYSAQKSTEPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLILTNNG-LYS 1195
            .||.:     |:...:   .||..|:....:..:.|..        |..|..|::.|:.:| :||
Human   312 AWGQNLHGQLGVGRKF---PSTTTPQIVEHLAGVPLAQ--------ISAGEAHSMALSMSGNIYS 365

  Fly  1196 LGNNNLCQLGIGRHMQMALQPMLVTALDGMNITMLEAGQYHNAAVA-DGKLYMWGWGIYGQLGQG 1259
            .|.|...|||:| |.:....|.|:..||...:..:..|..|:|.:. ||.|:.:|.|.:||||..
Human   366 WGKNECGQLGLG-HTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHN 429

  Fly  1260 SCENIATPQLVSFFKFKKILQISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNS 1324
            |.:|...|.||:.....::.||:.|..|||..         .:..| ::|.|||...||||.|.:
Human   430 STQNELRPCLVAELVGYRVTQIACGRWHTLAY---------VSDLG-KVFSFGSGKDGQLGNGGT 484

  Fly  1325 DHGDTKTNLPVRLEVGDCSLRL-IHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQK 1388
              .|....|||::...: .|:| .||        .|::.:...|.:...|....:.....|.|:.
Human   485 --RDQLMPLPVKVSSSE-ELKLESHT--------SEKELIMIAGGNQSILLWIKKENSYVNLKRT 538

  Fly  1389 MEENQQRELLSKQLEATLLPAPIPSTSTLVEPTTSYAAVVAGSTPKSSVS--------DTKDCQD 1445
            :....:..:  |:..|.:......||...::...|..|.:.||..:...:        |....::
Human   539 IPTLNEGTV--KRWIADVETKRWQSTKREIQEIFSSPACLTGSFLRKRRTTEMMPVYLDLNKARN 601

  Fly  1446 VQNEAAPSD-ATETIAPASAKAAPPPVPVASPP-------VLVPEPDPTEHLTPH----LVDTSE 1498
            :..|....| .|..|...........:|..|||       .|:|| .|..|::.:    :|..::
Human   602 IFKELTQKDWITNMITTCLKDNLLKRLPFHSPPQEALEIFFLLPE-CPMMHISNNWESLVVPFAK 665

  Fly  1499 VAGRILQISS-------------------GLFHFCLISSSCTLYTWGKNLEHQLGTE-------- 1536
            |..::...||                   .:|...:|   |.|..|.::.|.....:
Human   666 VVCKMSDQSSLVLEEYWATLQESTFSKLVQMFKTAVI---CQLDYWDESAEENGNVQALLEMLKK 727

  Fly  1537 ---DKDRRAVLKPSPIDSIERPMYVDCGSDFTLVMTTDHVV----------------RAFGGNSN 1582
               .|..:|.|:.:.|:. ||.........|.|.:..:|::                :....:.:
Human   728 LHRSKKHKAYLRSAAIEE-ERESEFALRPTFDLTVRRNHLIEDVLNQLSQFENEDLRKELWVSFS 791

  Fly  1583 GQCGRDLGPSVERMRQRVVCLPATKRLVRFE---------SQCVEVPVE---------------- 1622
            |:.|.||| .|:  ::...||.|  .:::.|         :.|:..||:
Human   792 GEIGYDLG-GVK--KEFFYCLFA--EMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCG 851

  Fly  1623 --------INLPRP----RIRLDQDP-VRYLKVMPP--------------------YQPHFLQPA 1654
                    .|||.|    :..|||.| :..||.:.|                    :..||
Human   852 LSLFNCNVANLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHF---- 912

  Fly  1655 NISFDQHCSVGTPNYKSSTEHAATGQDSDDMLSSLENLSQNDASFSYNAPVLGDAHSSLDMD--- 1716
            |:.:|::.:...||..|.|.:..   :..|.:|...|...||:..:.........:...|.|
Human   913 NVHWDRNDTNLIPNGSSITVNQT---NKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIK 974

  Fly  1717 -YTPEEQSYVPLPEQAVGSGMPANAEQLLGRDDDDGSTYTQS 1757
             :.|||...|                 ::|..|.|..|:.::
Human   975 LFHPEELKDV-----------------IVGNTDYDWKTFEKN 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	108/498 (22%)
		RCC1_2	1175..1200	CDD:290274	8/25 (32%)
		RCC1	1193..1240	CDD:278826	16/46 (35%)
		RCC1	1242..1291	CDD:278826	20/48 (42%)
		RCC1_2	1503..1532	CDD:290274	8/47 (17%)
		RCC1	1522..1568	CDD:278826	11/56 (20%)
		RCC1_2	1558..1584	CDD:290274	3/41 (7%)
HERC5	XP_011530324.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010