DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ca and Sergef

DIOPT Version :9

Sequence 1:NP_001287593.1 Gene:ca / 43518 FlyBaseID:FBgn0000247 Length:1961 Species:Drosophila melanogaster
Sequence 2:XP_038956885.1 Gene:Sergef / 365243 RGDID:1563497 Length:481 Species:Rattus norvegicus


Alignment Length:458 Identity:102/458 - (22%)
Similarity:169/458 - (36%) Gaps:139/458 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1050 VSHNSDCAMSNDNNPQLFEFCKS-LIETYLAVLIHMESQRVKYDSIV----NALSNFRINYEDNQ 1109
            :.|..|..:..    ||.:|||| .|::......|         |:|    ..|....:| :|.|
  Rat    30 LGHKEDVLLPQ----QLSDFCKSGCIKSVTGGGGH---------SVVVTDGGGLFVCGLN-KDGQ 80

  Fly  1110 FAI----ESSRF---KPISAGC--AYCACVVDGTAYF-------------WGSSGIPSYYSAQKS 1152
            ..:    |..||   ||: .||  ...||..|.|...             :|..|:|  :..:|.
  Rat    81 LGLGHTEEVLRFTICKPL-LGCPIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVP--HGPRKC 142

  Fly  1153 TEPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLILTN--------NGLYSLGNNNLCQLGIGRH 1209
            ..|       ::::.|.:   :|..:..|.:|.|..|:        .||.|.| ..||.   |::
  Rat   143 VVP-------QAIECLRE---KVVCVAAGLRHALATTDTGSTFQWGTGLASSG-RRLCP---GQN 193

  Fly  1210 MQM---ALQPMLVTALDGMNITMLEAGQYHNAAVAD-GKLYMWGWGIYGQLGQGSCENIAT---- 1266
            :.:   |.:|..||.|:...:....||..|:|::.| |:||:||...:|||.     ::||    
  Rat   194 LPLFLTAKEPSRVTGLESSTVVCAVAGSDHSASLTDTGELYVWGRNKHGQLA-----SLATFLPL 253

  Fly  1267 PQLVS--FFKFKKILQISLGHAHTLVLCG---APNSHMEANHCGNELFVFGSNHFGQLGTGNSDH 1326
            ||.|.  :|:.:|:..:..|..|.:...|   ||.:.|        |..|..|. |..|.     
  Rat   254 PQRVEAHYFQDEKVTAVWSGWTHLVAKTGNFRAPWTGM--------LCFFSVNR-GPRGA----- 304

  Fly  1327 GDTKTNLPVRLEVGDCSLRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEE 1391
                                        |...|..::||||.:..     .|:.|...:.:..:.
  Rat   305 ----------------------------LTTSETGKVFTWGRADY-----GQLGRTLGSPEAQKH 336

  Fly  1392 NQQRELLSKQLEATLLPAPIPSTSTLVEPTT-------SYAAVVAGSTPKSSVS-DTKDCQDVQN 1448
            .:|...|:.|.....:|:|:...:...|.|:       :.|.|....:|.|.:. ..:.|:..|:
  Rat   337 GEQDSSLAFQRLQNSVPSPLHCLTGAAEGTSAAPGAGMNMACVGTAPSPMSGLQLQCRPCRHHQD 401

  Fly  1449 EAA 1451
            .::
  Rat   402 SSS 404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
caNP_001287593.1 ATS1 1158..1588 CDD:227511 70/323 (22%)
RCC1_2 1175..1200 CDD:290274 9/32 (28%)
RCC1 1193..1240 CDD:278826 15/49 (31%)
RCC1 1242..1291 CDD:278826 18/55 (33%)
RCC1_2 1503..1532 CDD:290274
RCC1 1522..1568 CDD:278826
RCC1_2 1558..1584 CDD:290274
SergefXP_038956885.1 ATS1 17..>325 CDD:227511 88/377 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166337075
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.840

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