DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and Herc6

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	XP_008761185.1	Gene:	Herc6 / 362376	RGDID:	1561739	Length:	1027	Species:	Rattus norvegicus

Alignment Length:	721	Identity:	143/721 - (19%)
Similarity:	232/721 - (32%)	Gaps:	299/721 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly  1146 YYSAQKSTEPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLIL-TNNGLYSLGNNNLCQLGIGRH 1209
            |::.......|....|...|.||...:        |.:|:|:| :|:.:||.|:|:..||| .:.
  Rat     2 YFTWAPGRRQPRRLEAGTGLKLLKAAS--------GERHSLLLFSNHRVYSCGDNSRGQLG-QKS 57

  Fly  1210 MQMALQPMLVTALDGMNITMLEAGQYHNAAVA-DGKLYMWGWGIYGQLGQGSCENIA-TPQLVSF 1272
            .|...:|..:.||..::|.::..|:.|:.||. .|:::.||.|..||||.|..:.|: .|..::.
  Rat    58 PQSTKRPEPIQALSTVHIDLVSCGKEHSVAVCHQGRVFTWGAGSEGQLGIGESKEISFMPTKINS 122

  Fly  1273 FKFKKILQISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTKTNLPVRL 1337
            ....||:|:|.||.|:|.|..           ..::|.:|||..||||.||        ||
  Rat   123 LAGIKIIQVSCGHYHSLALSE-----------DGQVFSWGSNRQGQLGLGN--------NL---- 164

  Fly  1338 EVGDCSLRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEENQQRELLSKQL 1402
                ||                       .:|||.:                          |.|
  Rat   165 ----CS-----------------------QASPQKV--------------------------KSL 176

  Fly  1403 EATLLPAPIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKDCQDVQNEAAPSDATETIAPASAKAA 1467
            |.
  Rat   177 EG--------------------------------------------------------------- 178

  Fly  1468 PPPVPVASPPVLVPEPDPTEHLTPHLVDTSEVAGRILQISSGLFHFCLISSSCTLYTWGKNLEHQ 1532
               :|:|                              |:::|..|...:|...|.:.||.|...|
  Rat   179 ---IPLA------------------------------QVAAGGTHSFALSLMGTSFGWGNNRSGQ 210

  Fly  1533 L---GTEDKDRRAVLKPSPIDSIE--RPMYVDCGSDFTLVMTTDHVVRAFGGNSNGQ-------- 1584
            |   |...|::  :.||..|.:::  ..:|:.||.:.|.|:|.|..|..|||:|:.|
  Rat   211 LALSGNSAKEQ--IYKPHSIGALKTLNVVYISCGYEHTSVLTEDGQVFTFGGSSSEQLQHSPRSG 273

  Fly  1585 ------------------CGR----------------DLGPSV-------ERMRQRVVCLPATKR 1608
                              ||.                ..|||.       |.....|.||.:.|.
  Rat   274 RGGPQLIEGIGGHVSQIECGSYHTIAYVYTTGQVVSLGRGPSCTSNATHQEAACSDVTCLLSAKD 338

  Fly  1609 LV-------------RFESQCVE----------VPVEINLPRPRI---------RLDQDPVRYLK 1641
            ||             .|.:.|..          :|..|.:.:|.:         ::.:|..|.:.
  Rat   339 LVDIEVKDIFAGAHANFVTTCRHTRSTSVSMKILPEIIRITQPLVKKWRAAKKGKVHEDAKREIS 403

  Fly  1642 VMPPYQPHFLQPA--NISFDQHCSVGTPNYKSSTEHAATGQDSDDMLSSLENLSQNDASFSYNAP 1704
            ::      |..||  ..||.:....|..|:.:.....|  :|...||::.:.:|....:......
  Rat   404 LI------FSSPACLTASFLKKRDAGENNFINVDLKLA--RDVFKMLTAEKWISSLITTCLEETL 460

  Fly  1705 VLGDAHSSLDMDYTPEEQS---YVPLPEQAVGSGMPANAEQLLGRDDDDGSTYTQSTEGMGESSL 1766
            :.|..:||      |.:::   ::.|||.::... |.|.:.|       ...:..:...|...||
  Rat   461 LRGLPYSS------PHQEALLVFLLLPECSIMQD-PKNWKTL-------AFEFASAIHKMRSKSL 511

  Fly  1767 QHLRHY 1772
            ..||::
  Rat   512 TFLRNW 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	97/479 (20%)
		RCC1_2	1175..1200	CDD:290274	8/25 (32%)
		RCC1	1193..1240	CDD:278826	14/46 (30%)
		RCC1	1242..1291	CDD:278826	19/49 (39%)
		RCC1_2	1503..1532	CDD:290274	8/28 (29%)
		RCC1	1522..1568	CDD:278826	14/50 (28%)
		RCC1_2	1558..1584	CDD:290274	11/25 (44%)
Herc6	XP_008761185.1	RCC1	39..88	CDD:278826	15/49 (31%)
		RCC1	92..141	CDD:278826	19/48 (40%)
		RCC1	144..194	CDD:278826	25/210 (12%)
		RCC1_2	182..210	CDD:290274	9/57 (16%)
		RCC1_2	236..265	CDD:290274	12/28 (43%)
		RCC1	252..299	CDD:278826	9/46 (20%)
		HECTc	682..1023	CDD:238033
		HECTc	706..1023	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010