DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and herc1

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	XP_009301513.1	Gene:	herc1 / 336598	ZFINID:	ZDB-GENE-030131-8542	Length:	4867	Species:	Danio rerio

Alignment Length:	1156	Identity:	234/1156 - (20%)
Similarity:	384/1156 - (33%)	Gaps:	396/1156 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   935 LVTNSKYHTNMTSIVL--CQSGLFSSAIILAKIRGVCLDTFNALISVVAQEFGWYNELNV----- 992
            ||.||......|:.||  |::.|....::...: ..|:..|...:.::.||...|.:.:|
Zfish  3812 LVVNSSMEFMATNHVLATCRTALKKQGVVGLNM-APCMRAFLERLPIMLQEQYAYEKPHVVCGEQ 3875

  Fly   993 --------CLYNLSENIFLETITYLPHVSMDYFAFIQEKLHHIRPCVLQRLSKQLNPFSPALRPI 1049
                    ||.:||..:.|:.:...|.|.           .|:..|          |..|....|
Zfish  3876 LVHSPYMQCLASLSVGLQLDVLLCHPPVP-----------PHMAHC----------PPEPGSSSI 3919

  Fly  1050 VSHNS---------DCAMSNDNNPQLFEFCKSLIETYLAVLIHMESQRVKYDSIVNALSNFR-IN 1104
            .||.|         .|..:.....:......:..|:::.    .:.:.|..|.:...:.|.: ::
Zfish  3920 PSHGSWASSEWAWLHCFSTTIKTAEALARGHTFPESFIV----PDLEPVAKDKLALLMDNSKWVS 3980

  Fly  1105 YEDNQ-FAIESSRFKPISAGCAYCACVVDGTAYFWGSSGIPSYYSAQKSTEPPEPAHAVKSLDLL 1168
            ..|.| .:..:||.:....| ..|      ..:.||:........|.::...|..|.:..
Zfish  3981 GMDEQVMSWATSRPEDWHLG-GKC------DVFLWGAGRHGQLAEAGRNILVPTLAPSFS----- 4033

  Fly  1169 SQLNLQVHAIKCGRQHTLILTNNGLYS-LGNNNLCQLGIGRHMQM-------ALQPMLVTAL--- 1222
                 |...:.||:..|.::..||..| .|..:..:||.|....:       |||..:||.:
Zfish  4034 -----QAQQVVCGQNCTFVIQANGTVSACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQMVTS 4093

  Fly  1223 ---DGMNITMLEAGQYHNAAVADGKLYMWGWGIYGQLGQGSCENIATPQLVSFFKFKKILQISLG 1284
               ||.::.:.|:|:          ::.||.|.||:||.|:.:....|:.:...:.::::|:|.|
Zfish  4094 CGSDGHSMALTESGE----------VFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCG 4148

  Fly  1285 HAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTKTNLPVRL------EVGDCS 1343
            ..|:.|:..           ..:||.||:..:|:||.||:    :...||.|:      :||..:
Zfish  4149 FKHSAVVTS-----------DGKLFSFGNGDYGRLGLGNT----SNKKLPERVSALEGHQVGQVA 4198

  Fly  1344 LRLIHTKFFTNLAVDEQDRLFTW--GSSPQA-LRLANQIKRRANAKQKMEENQQRELLSKQLEAT 1405
            ..|.||     ||| ..|.:..|  |..... |.|.|...:  ::.||::
Zfish  4199 CGLNHT-----LAV-SADGMTVWAFGDGDYGKLGLGNSTAK--SSPQKVD--------------- 4240

  Fly  1406 LLPAPIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKD------CQDVQNEAAPSDATETIAPASA 1464
                        |........|..|:  :.||:.|||      .||
Zfish  4241 ------------VLCGIGIKKVACGT--QFSVALTKDGNVYTFGQD------------------- 4272

  Fly  1465 KAAPPPVPVASPPVLVPEPDPTEHLTPHLVDTSEVAGRILQ-ISSGLFHFCLISSSCTLYTWGKN 1528
                       ..:.:||.....|..|..|..  :.|..:: ::.|..|...:||:..:|.||.|
Zfish  4273 -----------RLIGLPEGRARNHNRPQQVPA--LTGVFIEDVAVGAEHTLTLSSTGDVYAWGSN 4324

  Fly  1529 LEHQLGTEDKDRRAVLKPSPIDSIERPMYVDCGSDFTLVMTTDHVVRAFGGNSNGQC-------- 1585
            .|.|||....:.  |.:|:.|.:::       |.:...:             |.|:|
Zfish  4325 SEGQLGLGHTNH--VREPTLISALQ-------GKNIQQI-------------SAGRCHSAAWTAP 4367

  Fly  1586 ---GRDLGPSVERMRQRVVCLPATKRLVRFESQCVEVPVEINLPRPRIRLDQDPVRYLKVMPPYQ 1647
               .|..|.||.......||:|.....:|      ||.:|  ..|.|:||     .|
Zfish  4368 PVPPRAPGSSVPLQLGLPVCVPPQYSALR------EVSME--ALRARLRL-----LY-------- 4411

  Fly  1648 PHFLQPANISFDQHCSVGTPNYKSSTEHAATGQDSDDMLSS--LENLSQNDASFS--YNA----- 1703
             ||                               ||.|.||  |.|||.|:.|.:  |||
Zfish  4412 -HF-------------------------------SDLMYSSWRLLNLSPNNQSCTSRYNAGTWGI 4444

  Fly  1704 ------PVLGDAHSSLDM------------DYTPE-------------EQSYVPLPEQAVGSG-- 1735
                  |:|.....:|.|            :|.|:             :..:|.:..|.|...
Zfish  4445 VQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNAS 4509

  Fly  1736 ---MPANA--EQLLGRD-DDDGSTYTQSTEGMGESSLQHLRHYIHYCLY-----AFHGLYNPDKI 1789
               :|:.|  .:|:|.. ||.|..:..:...|    .|.|...:...|.     |....||.|:.
Zfish  4510 DLRLPSRAWKVKLVGEGADDAGGVFDDTITEM----CQELETGVVDLLIPSPNAAAEVGYNRDRF 4570

  Fly  1790 ----GECARPHRNEYRIRICMLNFRFVEAFRLCLQSCGSAQRT-----LKLFEYFSKDTGYVPLR 1845
                ..|...|         :|.|:|:...      .|.|.||     |.|.....|....:||.
Zfish  4571 LLNPSACLEEH---------LLQFKFLGIL------MGVAIRTKKPLDLHLAPMVWKQLCCIPLS 4620

  Fly  1846 RTDLKH--LIY----HLCLH-----FLERKF-DMLECERFFMGDLDYYLLEL-----AYVFYFNN 1893
            ..||:.  |:|    :..||     ..|:.| :|:..:.|.....|..::.:     :....|:|
Zfish  4621 LEDLEEVDLLYVQTLNSILHLEDSGITEQNFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSN 4685

  Fly  1894 NNSTLEQNLNQKFKQLIAAADSNQAATSAG---------------QELEQL 1929
            ....:|:.:..:..::    |...||...|               ::|||:
Zfish  4686 RKEYVERAIEYRLHEM----DRQVAAVREGMSWIVPVPLLSLLTARQLEQM 4732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	98/470 (21%)
		RCC1_2	1175..1200	CDD:290274	7/25 (28%)
		RCC1	1193..1240	CDD:278826	14/60 (23%)
		RCC1	1242..1291	CDD:278826	13/48 (27%)
		RCC1_2	1503..1532	CDD:290274	9/29 (31%)
		RCC1	1522..1568	CDD:278826	12/45 (27%)
		RCC1_2	1558..1584	CDD:290274	2/25 (8%)
herc1	XP_009301513.1	RCC1	369..726	CDD:332518
		SPRY_HERC1	2004..2161	CDD:293939
		UBA_HERC1	2729..2772	CDD:270584
		WD40	3406..3773	CDD:330360
		WD40 repeat	3419..3452	CDD:293791
		WD40 repeat	3479..3514	CDD:293791
		WD40 repeat	3527..3569	CDD:293791
		WD40 repeat	3575..3611	CDD:293791
		WD40 repeat	3618..3660	CDD:293791
		WD40 repeat	3665..3710	CDD:293791
		WD40	3737..>3831	CDD:330360	7/18 (39%)
		WD40 repeat	3749..3784	CDD:293791
		RCC1	4004..4351	CDD:332518	99/459 (22%)
		HECTc	4479..4847	CDD:238033	53/277 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576218
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840