DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ca and HERC2

DIOPT Version :9

Sequence 1:NP_001287593.1 Gene:ca / 43518 FlyBaseID:FBgn0000247 Length:1961 Species:Drosophila melanogaster
Sequence 2:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster


Alignment Length:1580 Identity:291/1580 - (18%)
Similarity:507/1580 - (32%) Gaps:563/1580 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   390 EAATADVPPPPAPPSYSEAVARQSGDQGGVRFQQQQLPAGSMDG--------ILPATRA----RL 442
            :.|...:...|..|..|:|.::|.|:      |.|||.:||...        :|.||:|    ..
  Fly  2377 QRAPGSIYASPDEPDRSDAESQQPGE------QDQQLSSGSGQEPQLLIQCILLRATQASPVKAC 2435

  Fly   443 ASLKSLGSKKLQAIKMRLSDQRQKFDE---FMPDSTMGSFAIMDSPSVTPEPLGTTSGSFYNIQ- 503
            .|...|.:..|..|:...:...|:..|   ..|:.     ..:.||   |:|........||:. 
  Fly  2436 YSYMDLATAALNCIQSLATQAHQELSEGGGVPPNG-----RALSSP---PQPTMVHGVPVYNVAR 2492

  Fly   504 ---------NLRSTFLLSALHSN------SHSLTVHSIDISLKPLFVYKIPKHTQEILISSNILY 553
                     ..:|.:..:|..:.      ....|..:::::||.|.:......|.|.::.    :
  Fly  2493 KEQKPSEQVEQKSKWPAAATDAQLIGQIMEMGFTRRTVELALKQLSLQAEIMPTPEQIVQ----W 2553

  Fly   554 GIHYVDLHCRSDSDHFTAASLLDDPLVANTEKENRDADIEKVDQSDVSAQKSDSTSATTTATSSL 618
            .:.:.|: |.:..:..|.      ||.::....:.:||      ||.....|:||::::|::.::
  Fly  2554 ILEHPDV-CANTIEEDTL------PLASSASSHDPEAD------SDNECPSSNSTTSSSTSSDTV 2605

  Fly   619 DQSDMPSTAINAVSVISSAMASLHTSDEDRFNNLAQLGLFRFENETVLHLYQMAQYRNPSAEPET 683
            :...|      |||                                               .|..
  Fly  2606 EGQPM------AVS-----------------------------------------------GPAP 2617

  Fly   684 LTKEEKAKAFELKDIHTPMDYIQFYETADVSSEFSLRQM----EIMQSEFPKINYDPSYVITNKN 744
            ..|.|..|.|:..|::.      .|....|....::|..    ||.|.:...:     .::..:.
  Fly  2618 PVKFESRKDFQTADLYA------LYVRGLVRPGMTVRCCRDFEEIKQGDMGTV-----LIVDTEG 2671

  Fly   745 VYTIQLKKEPFELFLDAALQNEFNQCRDFCNTFDLSFEQCIEFAGDYLLRRKKITQALLTYNKAR 809
            ::.:.::.:                .|:..:|:.:.|...            ::.:|..|:::.|
  Fly  2672 LHDLNVQVD----------------WRNHGSTYWVCFVHI------------ELVEAAQTHHQPR 2708

  Fly   810 VKPIRTALKLAM------YGHTYAL-----MQLSAMALKSTYLLRSRYL-----GHPLLKGILGD 858
            ..||....::.:      ||....|     ...||:.:.|:  :||:.|     ..|..:|.:.:
  Fly  2709 PPPIAVGARVRLRTSSLRYGMLCPLRLGRSQGSSAIGVVSS--VRSKQLTVDFPDQPAWQGHINE 2771

  Fly   859 ITYRHSEDVRVILPEKHEEEDVNSGVFCSDYHYGVDESISALQMSPSSQFHLANLLLITL----- 918
            :....|:.....||        :.|..||             ||.||......:..:.:|     
  Fly  2772 VELVASQPTSATLP--------SLGDSCS-------------QMPPSDLIEDWSRCIRSLTVSSN 2815

  Fly   919 ---AEKAVNDKNY---------------IPLWNFLVTNS-------KYHTNMTSIVLCQSGLFSS 958
               |:..:|..|.               :.|.:.::.:|       :.|::|.|           
  Fly  2816 EAAAKHLLNGSNQPWQSCSSGPCRHWIRLELHDRILVHSLTLKVSPEDHSHMPS----------- 2869

  Fly   959 AIILAKIR-GVCLDTFNALISVVAQEFGWYNELNVCLYNLSENIFLETI-TYLPHVSMDYFAF-- 1019
               |.:|| |.|:|:.        :|:.|.    ......|..:.::.: ||.|.|.:.....  
  Fly  2870 ---LLEIRVGDCVDSL--------KEYTWI----PVPAGASRVLLMQQVPTYYPWVEVVVKQCQN 2919

  Fly  1020 --IQEKLHHIR----------PCVLQRLSKQLNPFSPALRP---------IVSHNSDCAMSNDNN 1063
              ||.|:|.|:          ..:|.......:.:|..:.|         ..||....|....:.
  Fly  2920 NGIQCKIHGIKFVGRRQQPDLQHILANAQFLASEYSAGVGPGSTAGAGAVSTSHEEAAAAPEQDL 2984

  Fly  1064 PQLFEFCKSLI-----ETYLAVLIHMESQRVKYDSIVNALSNFRINYEDNQFAIESSRFKPIS-A 1122
            |     |..::     :..|..|   :..:||..:                |:...||.:||. |
  Fly  2985 P-----CTVMVWGLNDKEQLGGL---KGSKVKVPT----------------FSQTISRLRPIHIA 3025

  Fly  1123 GCAYCACVV--DGTAYFWGSSGIPSYYSAQKSTEPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHT 1185
            |.:....:|  ||..|..| .|.........:...|.|    ..|.:|.|..::..|:..|.:|.
  Fly  3026 GGSKSLFIVSQDGKVYACG-EGTNGRLGLGVTHNVPLP----HQLPVLRQYVVKKVAVHSGGKHA 3085

  Fly  1186 LILTNNG-LYSLGNNNLCQLGIGRHMQMALQPMLVTALDGMNITMLEAGQYHNAAV-ADGKLYMW 1248
            |.||.:| ::|.|.....:||.|....:. :|.||.||....|..:..|..|:||: :.|:||.|
  Fly  3086 LALTLDGKVFSWGEGEDGKLGHGNRTTLD-KPRLVEALRAKKIRDVACGSSHSAAISSQGELYTW 3149

  Fly  1249 GWGIYGQLGQGSCENIATPQLVSFFKFKKILQISLG--HAHTLVLC--GAPNSHMEANHCGNELF 1309
            |.|.||:||.|.......|:||:....::::|::.|  .|.||.|.  ||             :|
  Fly  3150 GLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGA-------------VF 3201

  Fly  1310 VFGSNHFGQLGTGNSDHGDTKTNLP-------VRLEVGDCSLRLIHTKFFTNLAVDEQDRLFTWG 1367
            .:|...||:||.|.|:..||...:.       |::|.|        .:|  :||:.....::|||
  Fly  3202 SWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECG--------AQF--SLALTRAGEVWTWG 3256

  Fly  1368 SSPQALRLANQIKRRANAKQKMEENQQRELLSKQLEATLLPAPIPSTSTLVEPTTSYAAVVAGST 1432
            ..                                                     .|..:..|..
  Fly  3257 KG-----------------------------------------------------DYYRLGHGGD 3268

  Fly  1433 PKSSVSDTKDCQDVQNEAAPSDATETIAPASAKAAPPPVPVASPPVLVPEPDPTEHLTPHLVDTS 1497
            ..                                             |.:|.|...|.       
  Fly  3269 QH---------------------------------------------VRKPQPIGGLR------- 3281

  Fly  1498 EVAGRILQISSGLFHFCLISSSCTLYTWGKNLEHQLGTEDKDRRAVLKPSPIDSIERPMY--VDC 1560
              ..|::.::.|..|...::.:..:|.||.|...|.|:.:.....  ||:.:..::....  |.|
  Fly  3282 --GRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNK--KPALVIGLDAVFVNRVAC 3342

  Fly  1561 GSDFTLV-----MTTDHVVRA---FGGNSNGQCGRDLG----PSVERMRQRVVCLPATKRLVRFE 1613
            ||..::.     .::|...|.   |....:...|..||    .:::.::|....|..:.   ..|
  Fly  3343 GSSHSIAWGLPNASSDEEKRGPVPFSSTRDPLGGSSLGIYEAETMQTLKQEAKPLNQSS---LSE 3404

  Fly  1614 SQCVEVPVEINLPRPRIRLDQDPVRYLKVMPPYQPHFLQPANISFDQHCSVGTPNYKSSTEHAAT 1678
            |..:|.|.........:         |:.|...|...|..|.::  .|..|   |:|   |..|.
  Fly  3405 SLALETPAARQAALGHV---------LRAMSILQARQLIVAALT--SHSKV---NFK---ERGAV 3452

  Fly  1679 GQDSDDM---------LSSLENLSQ---------NDASFSYNAP----------VLGDAHS---- 1711
            |.:.|.:         |...|.::|         .||....::|          :.|.|::    
  Fly  3453 GGEEDHLIGGPIMGAPLQLAETIAQGGGEAPADATDAGLQEHSPEAAVDALTGGMSGGANTLPPL 3517

  Fly  1712 -------------SLDMDYTPEEQSYVPLPEQAVGSGMPANAEQLLGRDDDDGSTYTQSTEGMGE 1763
                         ||.|..:....:   || |...|.|.|:|..::      .:|.||.     |
  Fly  3518 SAGPLSAFQSLTGSLSMSGSLSSSA---LP-QHKHSRMSASAMSVM------AATMTQQ-----E 3567

  Fly  1764 SSLQHLRHYIHYCLYAFHGL 1783
            ..|.|:.|    |    |||
  Fly  3568 EMLSHISH----C----HGL 3579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
caNP_001287593.1 ATS1 1158..1588 CDD:227511 92/452 (20%)
RCC1_2 1175..1200 CDD:290274 9/25 (36%)
RCC1 1193..1240 CDD:278826 14/46 (30%)
RCC1 1242..1291 CDD:278826 19/50 (38%)
RCC1_2 1503..1532 CDD:290274 6/28 (21%)
RCC1 1522..1568 CDD:278826 12/52 (23%)
RCC1_2 1558..1584 CDD:290274 7/33 (21%)
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585 6/47 (13%)
Cul7 2624..2699 CDD:288381 12/113 (11%)
APC10-HERC2 2762..2932 CDD:176485 39/216 (18%)
RCC1 3037..3088 CDD:278826 14/55 (25%)
RCC1 3091..3140 CDD:278826 15/49 (31%)
RCC1 3144..3194 CDD:278826 19/49 (39%)
RCC1 3197..3246 CDD:278826 17/71 (24%)
RCC1 3250..3298 CDD:278826 12/154 (8%)
RCC1 3302..3350 CDD:278826 12/49 (24%)
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR22870
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.920

Return to query results.
Submit another query.