DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and Herc1

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	XP_017451567.1	Gene:	Herc1 / 315771	RGDID:	1306366	Length:	4876	Species:	Rattus norvegicus

Alignment Length:	1303	Identity:	246/1303 - (18%)
Similarity:	426/1303 - (32%)	Gaps:	477/1303 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   796 KKITQALLTYN-KARVKPIRTALKLAMYGHTYALMQLSAMALKSTYLLRSRYLGHPLLKGILGDI 859
            ||...|...|. :..:.|:||   :|......||:......|.:.:.||.   |..|...::|.
  Rat  3747 KKSAGAKCVYQLRGHITPVRT---VAFSSDGLALVSGGLGGLMNIWSLRD---GSVLQTVVIGS- 3804

  Fly   860 TYRHSEDVRVILPEKHEEEDVNSGV-FCSDYHYGVDESISALQMSPSSQFHLANLLLITLAEKAV 923
               .:....|.:||        .|| .||      :.|...|.::.::::..||.:|.|
  Rat  3805 ---GAIQTTVWIPE--------VGVAACS------NRSKDVLVVNCTAEWASANHILAT------ 3846

  Fly   924 NDKNYIPLWNFLVTNSKYHTNMTSIVLCQSGLFSSAIILAKIRGV-------CLDTFNALISVVA 981
                                       |::.|        |.:||       |:..|...:.::.
  Rat  3847 ---------------------------CRTAL--------KQQGVLGLNMAPCMRAFLERLPMML 3876

  Fly   982 QEFGWYNELNV-------------CLYNLSENIFLETITYLPHVSMDYFAFIQEKLHHIRPCVLQ 1033
            ||...|.:.:|             ||.:|:..:.|:.:...|
  Rat  3877 QEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCSP----------------------- 3918

  Fly  1034 RLSKQLNPFSPALRPIVSHNSDC----AMSNDNNPQLFEFCKSLIETYLAV---------LIHME 1085
                          |:..|:.:|    |..|.|.....|...:.|:...|:         ....:
  Rat  3919 --------------PVPPHHQNCPPDPASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFTVPD 3969

  Fly  1086 SQRVKYDSIVNALSNFR-INYEDNQ-FAIESSRFKPISAGCAYCACVVDGTAYFWGSSGIPSYYS 1148
            .:.|..|.:|..:.|.: ||..|.| .:..:||.:....| ..|      ..|.||:........
  Rat  3970 LEPVPEDELVLLMDNSKWINGMDEQIMSWATSRPEDWHLG-GKC------DVYLWGAGRHGQLAE 4027

  Fly  1149 AQKSTEPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLILTNNG-LYSLGNNNLCQLGIGRHMQM 1212
            |.::...|..|.:..          |...:.||:..|.::..|| :.:.|..:..:||.|....:
  Rat  4028 AGRNVMVPATAPSFS----------QAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDL 4082

  Fly  1213 -------ALQPMLVTAL------DGMNITMLEAGQYHNAAVADGKLYMWGWGIYGQLGQGSCENI 1264
                   |||..:||.|      ||.::.:.|:|:          ::.||.|.||:||.|:.:..
  Rat  4083 HVLTVISALQGFVVTQLVTSCGSDGHSMALTESGE----------VFSWGDGDYGKLGHGNSDRQ 4137

  Fly  1265 ATPQLVSFFKFKKILQISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDT 1329
            ..|:.:...:.::::|:|.|..|:.|:..           ..:||.||:..:|:||.||:    :
  Rat  4138 RRPRQIEALQGEEVVQMSCGFKHSAVVTS-----------DGKLFTFGNGDYGRLGLGNT----S 4187

  Fly  1330 KTNLPVRL------EVGDCSLRLIHTKFFTNLAVD-EQDRLFTWGSSPQA-LRLANQIKRRANAK 1386
            ...||.|:      ::|..:..|.||     |||. :...::.:|..... |.|.|...:  ::.
  Rat  4188 NKKLPERVTALEGYQIGQVACGLNHT-----LAVSADGSMVWAFGDGDYGKLGLGNSTAK--SSP 4245

  Fly  1387 QKMEENQQRELLSKQLEATLLPAPIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKD------CQD 1445
            ||::                           |........|..|:  :.||:.|||      .||
  Rat  4246 QKVD---------------------------VLCGIGIKKVACGT--QFSVALTKDGHVYTFGQD 4281

  Fly  1446 VQNEAAPSDATETIAPASAKAAPPPVPVASPPVLVPEPDPTEHLTPHLVDTSEVAGRILQ-ISSG 1509
                                          ..:.:||.....|..|..:..  :||.::: ::.|
  Rat  4282 ------------------------------RLIGLPEGRARNHNRPQQIPV--LAGVVIEDVAVG 4314

  Fly  1510 LFHFCLISSSCTLYTWGKNLEHQLGTEDKDRRAVLKPSPIDSIERPMYVDCGSDFTLVMTTDHVV 1574
            ..|...::|:..:|.||.|.|.|||....:.  |.:|:.:..::       |.:...:
  Rat  4315 AEHTLALASTGDVYAWGSNSEGQLGLGHTNH--VREPTLVTVLQ-------GKNIRQI------- 4363

  Fly  1575 RAFGGNSNGQCGRDLGPSVERMRQRVVCLPATKRLVRFESQCVEVPVEINLPRPRIRLDQDPVRY 1639
                  |.|:|......:.          |...|     :..|.||:::.||      |..|.:|
  Rat  4364 ------SAGRCHSAAWTAP----------PVPPR-----APGVSVPLQLGLP------DAVPPQY 4401

  Fly  1640 LKVMPPYQPHFLQPANISFDQHCSVGTPNYKSSTEHAATGQDSDDMLSS--LENLSQN--DASFS 1700
             ..:.....|.:: |.:....|.                   ||.|.||  |.|||.|  :::..
  Rat  4402 -GALREVSIHTVR-ARLRLLYHF-------------------SDLMYSSWRLLNLSPNNQNSTSH 4445

  Fly  1701 YNA-----------PVLGDAHSSLDM------------DYTPE-------------EQSYVPLPE 1729
            |||           |:|.....:|.|            :|.|:             :..:|.:..
  Rat  4446 YNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIAR 4510

  Fly  1730 QAVGSG-----MPANA--EQLLGRDDDDGSTYTQSTEGMGESSLQHLRHYIHYCLYAFHGL---- 1783
            |.|...     :|:.|  .:|:|...||..       |:.:.::..:      |.....|:
  Rat  4511 QVVKLNASDLRLPSRAWKVKLVGEGADDAG-------GVFDDTITEM------CQELETGIVDLL 4562

  Fly  1784 -----------YNPDKI----GECARPHRNEYRIRICMLNFRFVEAFRLCLQSCGSAQRT----- 1828
                       ||.|:.    ..|...|         ::.|:|:...      .|.|.||
  Rat  4563 IPSPNATAEVGYNRDRFLFSPSACLDEH---------LMQFKFLGIL------MGVAIRTKKPLD 4612

  Fly  1829 LKLFEYFSKDTGYVPLRRTDLKH--LIY----HLCLH-----FLERKF-DMLECERFFMGDLDYY 1881
            |.|.....|....|||...||:.  |:|    :..||     ..|..| :|:..:.|.....|..
  Rat  4613 LHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGK 4677

  Fly  1882 LLEL-----AYVFYFNNNNSTLEQNLNQKFKQLIAAADSNQAATSAG---------------QEL 1926
            ::.:     :....|:|....:|:.:..:..::    |...||...|               ::|
  Rat  4678 MVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEM----DRQVAAVREGMSWIVPVPLLSLLTAKQL 4738

  Fly  1927 EQL 1929
            ||:
  Rat  4739 EQM 4741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	93/458 (20%)
		RCC1_2	1175..1200	CDD:290274	6/25 (24%)
		RCC1	1193..1240	CDD:278826	14/59 (24%)
		RCC1	1242..1291	CDD:278826	13/48 (27%)
		RCC1_2	1503..1532	CDD:290274	8/29 (28%)
		RCC1	1522..1568	CDD:278826	11/45 (24%)
		RCC1_2	1558..1584	CDD:290274	2/25 (8%)
Herc1	XP_017451567.1	RCC1	421..472	CDD:278826
		RCC1	476..526	CDD:278826
		RCC1	529..576	CDD:278826
		RCC1	579..629	CDD:278826
		RCC1	633..680	CDD:278826
		RCC1_2	667..696	CDD:290274
		RCC1	683..733	CDD:278826
		SPRY_HERC1	2030..2187	CDD:293939
		UBA_HERC1	2751..2794	CDD:270584
		WD40	3409..3793	CDD:225201	12/48 (25%)
		WD40	3439..3790	CDD:295369	11/45 (24%)
		WD40 repeat	3447..3490	CDD:293791
		WD40 repeat	3504..3539	CDD:293791
		WD40 repeat	3544..3591	CDD:293791
		WD40 repeat	3600..3638	CDD:293791
		WD40 repeat	3644..3679	CDD:293791
		WD40 repeat	3687..3718	CDD:293791
		WD40 repeat	3765..3801	CDD:293791	10/41 (24%)
		RCC1	4060..4112	CDD:278826	14/51 (27%)
		RCC1	4115..4164	CDD:278826	14/58 (24%)
		RCC1	4167..4216	CDD:278826	17/57 (30%)
		RCC1	4219..4269	CDD:278826	11/80 (14%)
		RCC1	4272..4321	CDD:278826	11/80 (14%)
		RCC1_2	4308..4337	CDD:290274	8/28 (29%)
		RCC1	4325..4373	CDD:278826	14/69 (20%)
		HECTc	4488..4856	CDD:238033	50/286 (17%)
		HECTc	4519..4852	CDD:214523	47/255 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337079
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940