DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and Hectd3

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	XP_008762291.1	Gene:	Hectd3 / 313525	RGDID:	1309823	Length:	861	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	106/531 - (19%)
Similarity:	166/531 - (31%)	Gaps:	177/531 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 GPGAANSDP----STVSASAEAA---TADVPPPPAPPSYSEAVARQSGDQGGVRFQQQQLPAGSM 431
            |||||...|    ..|...||||   .|.:|.|.|    ...|.|:      |.::..:.|||..
  Rat     5 GPGAALESPRQLLGRVRFLAEAARSLRAGLPLPAA----LAFVPRE------VLYKLYKDPAGPS 59

  Fly   432 DGILPATRARLASLK--------SLGSKKLQAIKMRLSDQRQKFDEFMPDSTMGSFAIMDSPSVT 488
            ..:||...|....|:        ..||..|:|.:..:..:|            |:..     ..|
  Rat    60 RVLLPVWEAEGLGLRVGAAGPAPGTGSGPLRAARDSIELRR------------GACV-----RTT 107

  Fly   489 PEPLGTTSGSFYNIQNLRSTFLLSALHSNSHSLTVHSIDISLKP--LFVYK--------IPKHTQ 543
            .|.|....|.:..:              ....|..|..|.||..  |.|.:        :|..|.
  Rat   108 GEELCNGHGLWVKL--------------TKEQLAEHLSDCSLDEGWLLVCRPAEGGARLVPIDTP 158

  Fly   544 EILISSNILYGIHY---------VDL--------------------------------HCRSDSD 567
            :.|.....|:|:.|         |||                                .|..|..
  Rat   159 DHLQRQQQLFGVDYRPVLRWEQVVDLTYSHRLGSRPQPAEAYTEAVQRLLYVPPTWTYECDEDLI 223

  Fly   568 HFTAASLLDDPLVANTEKENRDADIEKVDQSDVSAQK--------SDSTSATTTATSSLDQSDMP 624
            ||     |.|.|  ..|.||..:..:.|:..|||:..        :||.:.|...:.........
  Rat   224 HF-----LYDHL--GKEDENLGSVKQYVESIDVSSYTEEFNVSCLTDSNADTYWESDGSQCQHWV 281

  Fly   625 STAINAVSVISSAMASLHTSDEDRF------------NNLAQLGLFRFENETVLHLYQMAQYRNP 677
            ...:...:::...:.::.|:| |.|            :||.:|.....:
  Rat   282 RLTMKKGTIVKKLLLTVDTTD-DNFMPKRVVVYGGEGDNLKKLSDVNID---------------- 329

  Fly   678 SAEPETLTKEEKAKAFELKDIHTPMDYIQFYETADVSSEFSLRQMEIMQSEFPKIN-----YDPS 737
                |||..:  ....|...:|.|:..|:..|..|...:..||.::|..|...::.     :.|:
  Rat   330 ----ETLIGD--VCVLEDMTVHLPVIEIRIVECRDDGIDVRLRGVKIKSSRQRELGLNADLFQPA 388

  Fly   738 YVI-------TNKNV-YTIQLKKEPFELFLDAALQNEFNQCRDFCNTFDLSFEQCIEFAGDYLLR 794
            .::       |:..| |...:..:.|...||:.|.:..........||. ..:|..:|   .||.
  Rat   389 SLVRYPRLEGTDPEVLYRRAVLLQRFIKILDSVLHHLVPAWDHTLGTFS-EIKQVKQF---LLLS 449

  Fly   795 RKK---ITQAL 802
            |::   :||.|
  Rat   450 RQRPSLVTQCL 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511
		RCC1_2	1175..1200	CDD:290274
		RCC1	1193..1240	CDD:278826
		RCC1	1242..1291	CDD:278826
		RCC1_2	1503..1532	CDD:290274
		RCC1	1522..1568	CDD:278826
		RCC1_2	1558..1584	CDD:290274
Hectd3	XP_008762291.1	APC10-HECTD3	238..371	CDD:176487	25/155 (16%)
Hectd3	XP_008762291.1	HECT	579..845	CDD:395507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010