DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ca and Herc2

DIOPT Version :9

Sequence 1:NP_001287593.1 Gene:ca / 43518 FlyBaseID:FBgn0000247 Length:1961 Species:Drosophila melanogaster
Sequence 2:XP_006229362.1 Gene:Herc2 / 308669 RGDID:1307989 Length:4836 Species:Rattus norvegicus


Alignment Length:1483 Identity:272/1483 - (18%)
Similarity:449/1483 - (30%) Gaps:571/1483 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   236 NSGQNRAIIGYSDGSICFVGLSPNCPMIASTAIENGSVMRLVICKDKAYDGVMLLITSSLKQQYK 300
            :|..:..|.|.|:   |    .||.|.:|.                     ::|.:..:|.:|..
  Rat  3361 SSSSSNKISGVSN---C----KPNRPSLAK---------------------ILLSLEGNLAKQQA 3397

  Fly   301 LLLEQKAIKYVYPGDSSPTTREGAWQIVMSVQDKHQSAATGARQSNSSDPASDSS------QLEE 359
            |.....|::.:|..|:          :|.::......|.......:||.||||.|      .:||
  Rat  3398 LSHILTALQIMYARDA----------VVGALMPAGMLAPVECPSFSSSAPASDVSAMASPMNVEE 3452

  Fly   360 DVFAPPSSDDVVCSGPGAANSDPSTVSASAEAATADVPPPPAPPSYSEAVARQSGDQGGVRFQQQ 424
            .:.|....|.:   .|.........|| |.:|.|.....|.||.:.|......:.|.|       
  Rat  3453 SMLAADLEDRL---SPNLWQEKREIVS-SEDAVTPSAVTPSAPSASSRPFIPVTDDPG------- 3506

  Fly   425 QLPAGSMDGILPATRARLASLKSLGSKKLQAIKMRLSDQRQKFDEF----MPDSTMGSFAIMDSP 485
               |.|:          :|...:...:.:::.......:.|..|||    :||.|.   .::|..
  Rat  3507 ---AASI----------IAETMTKTKEDVESQNKTSGPEPQSLDEFTSLLIPDDTR---VVVDLL 3555

  Fly   486 SVTPEPLGTTSGSFYNIQNLRSTFLLSALHSNSHSLTVHSIDISLKPLFVYKIPKHTQEILISSN 550
            .::   :.:.:|.       |...:|||:.|.                                 
  Rat  3556 KLS---VCSRAGD-------RGREVLSAVLSG--------------------------------- 3577

  Fly   551 ILYGIHYVDLHCRSDSDHFTAASLLDDPLVANTEKENRDADIEKVDQSDVSAQKS----DSTSAT 611
              .||.|..:           |.:|.:..|...|....|:...::....|..:.|    |.||.:
  Rat  3578 --MGIAYPQV-----------ADMLLELCVTELEDVATDSQSGRLSSQPVVVESSHPYTDDTSTS 3629

  Fly   612 TTA--------------TSSLDQSDMPSTAINAVSVISSAMASLHTSDEDRFNNLAQLGLFRFEN 662
            .|.              ..|.::...|.|.::.|:.|.|..:....||..               
  Rat  3630 GTVKIPGAEGLRVEFDRQCSTERRHDPLTVMDGVNRIVSVRSGREWSDWS--------------- 3679

  Fly   663 ETVLHLYQMAQYRNPSAEPETLTKEEKAKAFELKDIHTPMDYIQFYETADVSS-----EFSLRQM 722
                                             .::..|.|.:::...:|.|.     .|:    
  Rat  3680 ---------------------------------SELRIPGDELKWKFISDGSVNGWGWRFT---- 3707

  Fly   723 EIMQSEFPKINYDPSYVITNKNVYTIQLKKEPFELFLDAALQNEFNQCRDFCNTFDLSFEQCIEF 787
                                  ||.|.....|.:|..|        :|...|.:.||  ..|:. 
  Rat  3708 ----------------------VYPIMPAAGPKDLLSD--------RCVLSCPSMDL--VTCLL- 3739

  Fly   788 AGDYLLRRKKITQALLTYNKARVKPIRTALKLAMYGHTYALMQLSAMAL--KSTYLLRSRYLGHP 850
              |:.|.        ||.|::.|.  |.|..||      |..||||:|.  :...|.|.|.|   
  Rat  3740 --DFRLN--------LTSNRSIVP--RLAASLA------ACAQLSALAASHRMWALQRLRRL--- 3783

  Fly   851 LLKGILGDITYRHSEDVRV--ILPEKHEEEDVNSGVFCSDYHYGVDESISALQMSPSSQFHLANL 913
                    :|....:.:.:  :|.|.                   |....||..:.|:   || .
  Rat  3784 --------LTTEFGQSININRLLGEN-------------------DGETRALSFTGSA---LA-A 3817

  Fly   914 LLITLAEKAVNDKNYIPLWNFLVTNSKYHTNMTSIVLCQSGLFSSAIILAKIRGVC---LDTFNA 975
            |:..|.|.......|   .:.:|...|.        |..|..|...:.||     |   |||...
  Rat  3818 LVKGLPEALQRQFEY---EDPIVRGGKQ--------LLHSPFFKVLVALA-----CDLELDTLPC 3866

  Fly   976 LISVVAQEFGWYNELNVCLYNLSEN--IFLETITYLPHVSMDYFAFIQEKLHHIRPCVLQRLSKQ 1038
            ...  ..::.|:..     |.::..  :.|:..|.||.:      |:.|....||..:....|..
  Rat  3867 CAE--THKWAWFRR-----YCMASRVAVALDKRTPLPRL------FLDEVAKKIRELMADSESMD 3918

  Fly  1039 LNPFSPALRPIVSHNSDCAMSNDNNPQLFEFCKSLIE-----------------TYLAVLIHMES 1086
                       |.|.|......:.:.||.::.....:                 .:...|..:|.
  Rat  3919 -----------VLHESHSIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEG 3972

  Fly  1087 QRVKYDSIVNALSNFR----INYEDNQFAIESSRFKPISAGCAYCACVVDGTAYF--WGSSGIPS 1145
            .:||..:...||:..|    |..|...||:                 ..||..|.  :|:.|...
  Rat  3973 AKVKVPTPCEALATLRPVQLIGGEQTLFAV-----------------TADGKLYATGYGAGGRLG 4020

  Fly  1146 YYSAQKSTEPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLILTNNG-LYSLGNNNLCQLGIGRH 1209
            ....:..:.|       ..|:.:..:.::..|:..|.:|.|.|::.| :||.|.....:||.|..
  Rat  4021 IGGTESVSTP-------TLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNR 4078

  Fly  1210 MQMALQPMLVTALDGMNITMLEAGQYHNAAV-ADGKLYMWGWGIYGQLGQGSCENIATPQLVSFF 1273
            .... :|.::.:|.|:.:..:.||..|:|.| |.|.||.||.|.||:||....|:...|:||...
  Rat  4079 SPCD-RPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEAL 4142

  Fly  1274 KFKKILQISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHG-------DTKT 1331
            :..:::.|:.|......||...:         :.::.:|...:|:||.|.|| |       |:.|
  Rat  4143 QGHRVIDIACGSGDAQTLCLTDD---------DTVWSWGDGDYGKLGRGGSD-GCKVPMKIDSLT 4197

  Fly  1332 NL-PVRLEVGDCSLRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEENQQR 1395
            .| .|::|.|        ::|  ::|:.:...::|||..                          
  Rat  4198 GLGVVKVECG--------SQF--SVALTKSGAVYTWGKG-------------------------- 4226

  Fly  1396 ELLSKQLEATLLPAPIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKDCQDVQNEAAPSDATETIA 1460
                                       .|..:..||  ...|...:..|.:|.:           
  Rat  4227 ---------------------------DYHRLGHGS--DDHVRRPRQVQGLQGK----------- 4251

  Fly  1461 PASAKAAPPPVPVASPPVLVPEPDPTEHLTPHLVDTSEVAGRILQISSGLFHFCLISSSCTLYTW 1525
                                                     :::.|::|..|....:....:|||
  Rat  4252 -----------------------------------------KVIAIATGSLHCVCCTEDGEVYTW 4275

  Fly  1526 GKNLEHQLGTEDKDRRAVLKPSPIDSIE--RPMYVDCGSDFTLVMTTDHVVRAFGGNSNGQCGRD 1588
            |.|.|.|||  |....|:.:|..:.:::  :...|.|||..||..:|.....|         |: 
  Rat  4276 GDNDEGQLG--DGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASA---------GK- 4328

  Fly  1589 LGPSVERMRQRVVCLPATKRLVRFESQCVEVPVEINLPRPRIRLDQDPVRYLK 1641
                          |||            :||:|.|      .|.:.|:..|:
  Rat  4329 --------------LPA------------QVPMEYN------HLQEIPIIALR 4349

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
caNP_001287593.1 ATS1 1158..1588 CDD:227511 89/441 (20%)
RCC1_2 1175..1200 CDD:290274 9/25 (36%)
RCC1 1193..1240 CDD:278826 13/46 (28%)
RCC1 1242..1291 CDD:278826 16/48 (33%)
RCC1_2 1503..1532 CDD:290274 9/28 (32%)
RCC1 1522..1568 CDD:278826 18/47 (38%)
RCC1_2 1558..1584 CDD:290274 8/25 (32%)
Herc2XP_006229362.1 ATS1 <494..787 CDD:227511
Cyt-b5 1212..1283 CDD:395121
MIB_HERC2 1871..1931 CDD:399589
UBA_HERC2 2461..2508 CDD:270585
Cul7 2555..2632 CDD:402903
SH3_15 2640..2697 CDD:408152
ZZ_HERC2 2707..2751 CDD:239084
APC10-HERC2 2766..2911 CDD:176485
ATS1 2957..3323 CDD:227511
ATS1 4025..4330 CDD:227511 90/465 (19%)
HECTc 4423..4794 CDD:238033
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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