DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and Nek9

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	NP_001100217.2	Gene:	Nek9 / 299204	RGDID:	1307187	Length:	976	Species:	Rattus norvegicus

Alignment Length:	1008	Identity:	192/1008 - (19%)
Similarity:	312/1008 - (30%)	Gaps:	373/1008 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   845 RYLGHPLLKGILGDIT-YRHSEDVRVI---------LPEKHEEEDVNSGV---------FCSDYH 890
            |.||    :|..|:.| ||.:||..::         |.||...:.:|..|         ..:.|:
  Rat    55 RVLG----RGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYN 115

  Fly   891 YGVDESISALQMSPSSQFHLANLLLITLAEKAVNDKNY---IPLWNFLVTNSKYHTNMTSIVLCQ 952
            :.:|.:...:::...:..:|.:.:|      ...||.:   :.:|        |...:.|.|.|
  Rat   116 HFMDNTTLLIELEYCNGGNLYDKIL------RQKDKLFEEEMVVW--------YLFQIVSAVSC- 165

  Fly   953 SGLFSSAIILAKIRGVCLDTFNALIS----VVAQEFGWYNELNVCLYNLSENIFLETITYLPHVS 1013
              :..:.|:...|:     |.|..::    :...::|...:||      ||....||:...|:
  Rat   166 --IHKAGILHRDIK-----TLNIFLTKANLIKLGDYGLAKKLN------SEYSMAETLVGTPY-- 215

  Fly  1014 MDYFA--FIQEKLHHIRP------CV------LQRLSKQLNPFSPALRPIVSHNSDCAMSNDNNP 1064
              |.:  ..|...::.:.      ||      |:|.....||.:..::.:....   ||..|::
  Rat   216 --YMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIR---AMEVDSS- 274

  Fly  1065 QLFEFCKSLIETYLAVLIHMESQRVKYDSIVN--ALSNFRINYEDNQFAIESSRFKPISAGC--A 1125
               ::...||:...|.|.....:|...|::::  .|...|...|:....:.:...:|.|:..  |
  Rat   275 ---QYSLGLIQLVHACLDQDPERRPTADALLDLPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEA 336

  Fly  1126 YCACVVDGTA--YFWGSSGIPSYYSAQKSTEPPEPAHAVKS--------------------LDLL 1168
            ..|.|...|:  |.||..         |||  |:....:||                    .:|.
  Rat   337 PIAVVTSRTSEVYVWGGG---------KST--PQKLDVIKSGCSARQVCAGNTHFAVVTVEKELY 390

  Fly  1169 SQLNLQ------------------------------VHAIKCGRQHTLILTNNG-LYSLGNNNLC 1202
            :.:|:|                              :|.:.||...|:.:|:.| ||:.|::...
  Rat   391 TWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYG 455

  Fly  1203 QLGIGR-HMQMALQPMLVTALDGMNITMLEAGQYHNAAVADGK-LYMWGWGIYGQLGQGSCENIA 1265
            .:|:.: .....|:||.:.......:..:..|..|...:...| :|.||.|.||:||..|.|:..
  Rat   456 CMGVDKVSGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYY 520

  Fly  1266 TPQLVSFFKFKKILQISLGHAHTLVL--------CG----------------------------- 1293
            |||.|...|...|:.:..|...|.:|        ||
  Rat   521 TPQRVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTT 585

  Fly  1294 ----------------AP-NSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTKTNLPVRLEVGD 1341
                            || .:|..|......|..||.|..||||.||     .|..|.:.|..|.
  Rat   586 SFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGN-----YKKRLGINLLGGP 645

  Fly  1342 CS----LRLIHTKFFTNLAVDEQDRLFTWG----------------------SSPQAL------- 1373
            ..    :|:.....||..|.|: :.:|.||                      |.|:.:
  Rat   646 LGGKQVIRVSCGDEFTIAATDD-NHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHV 709

  Fly  1374 ---------------RLANQIKRRANAKQKM--------------------EENQQRE------- 1396
                           ::.|....|:|:....                    ||:.|:|
  Rat   710 PDLSCRGWHTILIVEKVLNSKTIRSNSSGLSIGTVVQSSSPGGRIGGGGGEEEDSQQESETPDPS 774

  Fly  1397 -----------------------------------LLSKQLE-ATLLPAPIPSTSTLVEPTTSYA 1425
                                               .|.|:|| |..:|.|       ..||...|
  Rat   775 GGFRGTMEADRGMEGLISPTEAVGNSCGASSSCPGWLRKELENAEFIPMP-------DSPTPLSA 832

  Fly  1426 AVVAGSTPKSSVSDTKDCQDVQNEAAPSDATETIAPASAKAAPPPVPVASPPVLVPEPDPTEHLT 1490
            |.      ..|..||...:::|.....|:......|| ..|.||.:..|.|.|......|....:
  Rat   833 AF------SQSEKDTLPYEELQGLKVASEVPPEHQPA-VGAWPPRLNPAVPCVGKALTSPACACS 890

  Fly  1491 PHLVDTSEVAGRILQISSGLFHFCL----------ISSSCTLYTWGKNLE-------HQLGTEDK 1538
            ...|:...:.|.:|:        ||          :.....|....|.||       |..||:..
  Rat   891 ALQVEVERLQGLVLK--------CLDEQQKLQQENLQIVTQLQKLNKRLEGGQQVGMHSRGTQTA 947

  Fly  1539 DRRAVLKPSPIDSIERPMYVDCGSDFTLVMTTD 1571
            .....:.|.|          |..||...::.||
  Rat   948 KEDMEMDPKP----------DLDSDSWCLLGTD 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	121/649 (19%)
		RCC1_2	1175..1200	CDD:290274	9/25 (36%)
		RCC1	1193..1240	CDD:278826	9/47 (19%)
		RCC1	1242..1291	CDD:278826	19/49 (39%)
		RCC1_2	1503..1532	CDD:290274	7/45 (16%)
		RCC1	1522..1568	CDD:278826	12/52 (23%)
		RCC1_2	1558..1584	CDD:290274	5/14 (36%)
Nek9	NP_001100217.2	STKc_Nek9	50..297	CDD:270860	54/284 (19%)
Nek9	NP_001100217.2	ATS1	344..687	CDD:227511	76/359 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010