DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and Zzef1

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	XP_006246919.1	Gene:	Zzef1 / 287476	RGDID:	1311189	Length:	2965	Species:	Rattus norvegicus

Alignment Length:	2279	Identity:	405/2279 - (17%)
Similarity:	650/2279 - (28%)	Gaps:	959/2279 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LVSEENEILLRYIS--AASGQEVVKMISWFRNRVIHDV----C-----------FDPAGVWLLVL 89
            |||..:..|||::.  ...|:|.|.:..:   |.:.:.    |           ||..|
  Rat    72 LVSRHHGALLRWLEERLGRGEESVTLEQF---RELLEARGAGCSGEQFEEAFAQFDAEG------ 127

  Fly    90 CFDNTLHIVPALALVDKAHG-------------LSACSL-----------------YST------ 118
              |.|:.....|..:..:.|             |.||||                 :|:
  Rat   128 --DGTVDAENMLEALKNSSGANLQGELSHVIRQLQACSLVPGFIDIFSESKEGLGTHSSMILRFL 190

  Fly   119 --TQVTSYIIPFVGPHECPNSKKCPNHSTGLEESTAEPMDQLAENLEQA---------------- 165
              .:|:|.:||:.....|.|  .|...|:.|::|    :|||.:..:::
  Rat   191 HRNRVSSMVIPYPMLDHCNN--MCTMRSSVLKDS----LDQLLQKEKESPGDLARSPEMDKLKSV 249

  Fly   166 -----------------RLQEGEEEEPLGHD----------------LPEHMLVRNSGTEDAVQP 197
                             |:..||.......|                :..|:.:..:.|:.:..|
  Rat   250 TKCYAYIETSSNPADIYRMTNGETSSYWQSDGSARSHWIRLKMKPDVVLRHLSIAVAATDQSYMP 314

  Fly   198 LPQQQQTI-------------------DTTG------NSQV------------------------ 213
               ||.|:                   :.||      |:.:
  Rat   315 ---QQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDTRIHGL 376

  Fly   214 MAASFMASKTCPYPL---SVVWW------------KTNSG-------------QNRAIIGYSDGS 250
            .|..|...|.....:   |.:|:            :||..             |:...:..|.||
  Rat   377 RAVGFQRVKKSGVSVSDASAIWYWSLLTSLVTASMETNPAFVQTVLHNTQKALQHMPPLSLSPGS 441

  Fly   251 ICF-VGLSPN---------------C--PMIAST----AIENGSVMRLV--ICK-----DKAYDG 286
            ..| ..||||               |  |.:..|    |:..||:.:::  :|.     |..||
  Rat   442 TDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAFALARGSIAKVMSSLCAISDHLDTQYD- 505

  Fly   287 VMLLITSSLKQQYKLLLEQKAIKYVYPGDSSPTTREGAWQIVMSVQDKHQSAATGARQSNSSDPA 351
            ...||:|....:..|||     ||..|             :.:::|     |.....:.:.|.|
  Rat   506 ASSLISSMASVRQSLLL-----KYGKP-------------LQLTLQ-----ACDVKGKEDKSGP- 546

  Fly   352 SDSSQLEEDVFAPPSSDDVVCSGPGAANSDPSTV-SASAEAATADVPPPPAPPSYSEAVARQSGD 415
                   |::...|.:.|...:..|...:  ||: ||..|:|            :.....|....
  Rat   547 -------ENLLVEPWTRDGFLTETGKTRA--STIFSAGTESA------------FQVTQIRIMVR 590

  Fly   416 QGGVRFQQQQLPAGSMDGILPA--------------------TRARLASLKSLGSKKLQAIKMRL 460
            :||:         |:..|::.|                    .|.:|..|:       |.:|.|:
  Rat   591 RGGI---------GAQCGLVFAYNSPSDKFHAEEHFKRFEKYDRWKLQELR-------QFVKSRI 639

  Fly   461 SDQRQKFDEFMPDSTMGSFAI---MDSPSVTPEPLGTTSGSFYNIQNLR-STFL----LSALHSN 517
            ....   |:...|..:|.|.:   .|...|             .:|..| :.||    |.....:
  Rat   640 GCSP---DDLGEDDPIGWFELEEEWDEADV-------------KLQQCRVAKFLMVKFLCTRQES 688

  Fly   518 SHSLTVHSIDISLKPLFVYKIPKHTQEILISSNILYGIHYVDLHCRSDSDHFTAASLLDDPLVAN 582
            :..|.|..:.||     .|..|...:   ...:|||.      |||.|:::...|:||...|
  Rat   689 AERLGVQGLSIS-----GYLRPARAE---AEQSILYA------HCRRDTENIYGATLLLRTL--- 736

  Fly   583 TEKENRDADIEKVDQ--SDVSAQKSDSTSATTTATSSLDQSDMPSTAINAVSVISSAMASLHTSD 645
                      :.:.|  .|:..||.......:
  Rat   737 ----------QFIQQLAHDLVQQKESGLKYKS--------------------------------- 758

  Fly   646 EDRFNNLAQLGLFRFEN----------------ETVLHLYQMAQYRNPSAEPETLTKEEKAKAFE 694
               |.:.|.|.|..|.|                :|:|.....:.:.....:|:.:::|||..|..
  Rat   759 ---FLDFAGLDLQIFWNFYSKLKQNPREECICAQTLLLQLLQSCFSVLQGDPQAVSEEEKPAAQR 820

  Fly   695 LKDIHTPMD-YIQFYETADVSSEFSLRQMEIMQSE------------FPKINYDPSYVIT-NKNV 745
            .:.|....: |....:..|.:...|: .|||::.|            ||......:.:.| .|||
  Rat   821 PEGIQAAKELYTHLCDVVDRADGESM-PMEILKQEVRNTLLNGAAIFFPDRQTRRNQLFTMMKNV 884

  Fly   746 YTIQLKKEPFELFLDAALQNEFNQCRDFCNTFDLSFEQCIEFAGDYLLRRKKITQALLTYNKARV 810
            ...:.|:         :||..|   |..|..|.      .:..|..||..:|  ..|.|.|.:.|
  Rat   885 TEHERKQ---------SLQLTF---RSLCTYFS------DKDPGGLLLLPEK--SDLATMNTSEV 929

  Fly   811 KPIRTAL--------KLAMYGHTY----------------ALMQLSAMALKSTYLLRSRYLGHPL 851
            ..:...|        :|.|.|..:                :|:....:.||||. ..::.|...|
  Rat   930 LAVMNTLLSVAARECELLMLGRAHGEVGSVLFSLFWSVQGSLLSWCFLQLKSTD-AAAKELAMDL 993

  Fly   852 LKGILGDITYRHSEDVRVILPE-------KHEEEDVNSGVF------------------------ 885
            ::..:|...    ..:||||..       |...|.:.:.||
  Rat   994 IEKYVGQFL----ASMRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDVSHCTL 1054

  Fly   886 --------------CSDYHYGVDE-SISALQMSPSSQFHL-----------------------AN 912
                          |||...|:.: .:...|.......|.                       |.
  Rat  1055 LREFSTLTELLKKLCSDPEGGLSKLDVETWQQEQPVVLHTWTKESTHNYENNCHEVSVFVSPGAT 1119

  Fly   913 LLLITLAEKAVNDKNYIPLWNFL-VTNS-----KYHTNMTSI-----VLCQSG-----LFSSAII 961
            ...:...|:...:|.|    ::| .|:|     :|.|.:.:.     |..:.|     ||.|
  Rat  1120 YFEVEFDERCETEKRY----DYLEFTDSRGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHS--- 1177

  Fly   962 LAKIRGVCLDTFNALISVVAQEFGWYNELNVCLYNLSENIFLETITYLPHVSMDYFAFIQEKLHH 1026
                     |:.|       .|:|:  :..|..|.            ||.|::.:...:|
  Rat  1178 ---------DSSN-------NEWGY--KFTVTAYG------------LPDVAVSWGLDLQ----- 1207

  Fly  1027 IRPCVLQRLSKQLNPFSPALRPIVSHNSDCAMSND------NNP---QLF--EFCKSL-IETYLA 1079
               .::.||..:|.....||:.:....|:.|:|..      |:|   .:|  :.|..| :|....
  Rat  1208 ---LLVSRLMGRLASQCMALKSVHQLGSNLAISQAKLTAVLNSPLWKPVFRHQICPELELEASWP 1269

  Fly  1080 VLIHMESQRVKY---DSIVNALSNFRINYEDNQF-AIESSRFKPISAGCAYCACVVDGTAYFWGS 1140
            ...|.:.:.||.   |...:.|.:|..:.....| ...|..||.....|...|...|..|   ||
  Rat  1270 THPHQDGKEVKNIPDDPCRHFLLDFAQSEPAQNFCGPYSELFKGFIQACRKQAPKTDIVA---GS 1331

  Fly  1141 SGIPSYYSAQKSTEPPEPAHAVKSLDLLSQLNLQVHAIKCGRQHTLILTNNGLYSLGNNNLCQLG 1205
                   :..::......|...::.||..:|...||:   |.:..|....:.:|||.
  Rat  1332 -------TIDQAVNATFAALVYRTPDLYEKLQKYVHS---GGKIALPEEFSQVYSLA-------- 1378

  Fly  1206 IGRHMQMALQPMLVTALDGMNITMLEAGQYHNAAVADGKLYMWGWGIYGQLGQGSCENIATPQLV 1270
                             ||:.|.|||..|....::.:......|.    :..:.:.||:|
  Rat  1379 -----------------DGIRIWMLEMKQKSLVSMGNDSEEKRGL----ETAEVNPENLA----- 1417

  Fly  1271 SFFKFKKILQISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTKTNLPV 1335
                 |:.:|.||     |:|...|.|.....:|.
  Rat  1418 -----KECIQKSL-----LLLKFLPMSKSSKENCD------------------------------ 1442

  Fly  1336 RLEVGDCSLRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEENQQRELLSK 1400
                     :|:        .|||.|||             ..:.||......:||:.|..  :.
  Rat  1443 ---------KLV--------PVDETDRL-------------QPLDRRQRTSSVVEEHFQGS--AS 1475

  Fly  1401 QLEATLLPAPIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKDCQDVQNEAAPSDATETIAPASAK 1465
            ..||....|...|....::|     .::..|.|.:              |..|.|.|..:|::..
  Rat  1476 PTEAATPAADDKSPGLEMQP-----KLLPSSGPSA--------------AEVSTAEEPSSPSTPT 1521

  Fly  1466 AAPP------------------PVPVASP--PVLVPEPDPTEHLTPHLVDTS---EVAGRILQI- 1506
            ..||                  |||....  |||       :.:...:.|.|   |...::|.:
  Rat  1522 RRPPFTRGRLRLLSFRSMEETRPVPTVKEKYPVL-------KDVMDFIKDQSLSHESIVKVLSLR 1579

  Fly  1507 ---SSGLFHFCLISSSCTLYTWGKNLEHQLGTEDKDRRAVLKPSPIDSIERPMYV-------DCG 1561
               :..:.....|...||         ..||          :|...    .|.|:       .|.
  Rat  1580 KAQAQSILEVLRIIQYCT---------ESLG----------QPHCF----HPPYILFLLELLTCQ 1621

  Fly  1562 SDFTLVMTTDHVVRAFGGNSNGQCGRDLGPSVERMRQRVVCLPATKRLVRFES----------QC 1616
            .|||          .:.|:..| ||.||...:.....::| |...|.:..|.|          .|
  Rat  1622 KDFT----------NYFGHLEG-CGADLHKEIRDTYYQLV-LFLVKAIKGFSSINDRSLLPAVSC 1674

  Fly  1617 VEVP-----------------VEINLPRPRIRLDQDPVRYLKVMPPYQPHFLQPANISFDQHCSV 1664
            |:..                 |:|.||...:.:.|:                   |||.  |.||
  Rat  1675 VQTALLHLLDMGWEPSDLAFFVDIQLPDLLMNMSQE-------------------NISI--HDSV 1718

  Fly  1665 GTPNYKSSTEHAATGQDS-------DDMLSS-LENLSQNDASFSYNAPVLGDAHSSLDMDYTPEE 1721
             ...:....|.|...|:|       |.|..: .|.::|.|                      ||:
  Rat  1719 -ISQWSEEDELADAKQNSEWMDECQDGMFEAWYEKIAQED----------------------PEK 1760

  Fly  1722 QSYVPLPEQAVGSGMPANAEQLLGRDDDDGSTYTQSTEGMGESSLQHLRHYIH-----YCLYAFH 1781
            |..:.:        ..|....||..|        .|.:|..|.:..|....:.     .|...|.
  Rat  1761 QRKMHM--------FIARYCDLLNVD--------ISCDGCDEIAPWHRYRCLQCSDMDLCKTCFL 1809

  Fly  1782 GLYNPDKIGECARPHRNEYRIRICM-------LNFRFVEAFRLCLQSCGSAQRTLKLFEYFSKDT 1839
            |...|:..|:.......|:....|.       :|....:.|.|| ..|.:|    |.:.|
  Rat  1810 GGVKPEGHGDDHEMVNMEFTCDHCQGLIIGRRMNCNVCDDFDLC-YGCYAA----KKYSY----- 1864

  Fly  1840 GYVP 1843
            |::|
  Rat  1865 GHLP 1868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	83/463 (18%)
		RCC1_2	1175..1200	CDD:290274	7/24 (29%)
		RCC1	1193..1240	CDD:278826	10/46 (22%)
		RCC1	1242..1291	CDD:278826	9/48 (19%)
		RCC1_2	1503..1532	CDD:290274	4/32 (13%)
		RCC1	1522..1568	CDD:278826	9/52 (17%)
		RCC1_2	1558..1584	CDD:290274	5/32 (16%)
Zzef1	XP_006246919.1	EFh	<94..141	CDD:238008	9/57 (16%)
		APC10-ZZEF1	250..380	CDD:176488	14/132 (11%)
		CUB	<1119..1189	CDD:294042	17/94 (18%)
		ZZ_EF	1779..1826	CDD:239083	9/46 (20%)
		ZZ	1828..1875	CDD:239069	11/51 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900