Protein Alignment ca and HECTD4

DIOPT Version :10

• Sequence 1: NP_733309.3
• Gene: ca / 43518
• FlyBaseID: FBgn0000247
• Length: 1961
• Species: Drosophila melanogaster
• Sequence 2: NP_001103132.4
• Gene: HECTD4 / 283450
• HGNCID: 26611
• Length: 4428
• Species: Homo sapiens
• Alignment Length: 1861
• Identity: 333/1861 - (17%)
• Similarity: 572/1861 - (30%)
• Gaps: 702/1861 - (37%)

  Fly   111 SACSLYSTTQ-VTSYIIPFVGPH-ECPNSKKCPNHSTGLEESTAEPMDQLAENLEQARLQEGEEE 173
            :|.:|...|: ..|.:|..:||. |..|.:.....|||.::.||:.......|.|.||      .
Human  2020 AAAALRKATKWAQSGLIVSIGPPVESINPETVSGLSTGDKKKTAQTSICRERNSELAR------T 2078

  Fly   174 EPLGHDLPEHMLVRNSGTEDAV--------QPLPQQQQTIDTTGNSQVMAASFMASKTCPYPLSV 230
            :|:...:..|  |.||...:.:        .|.....|...||....:..|.....:...|..|:
Human  2079 DPVRPFISGH--VANSMAAEVIALLHSLLMAPESNAAQIWTTTAEKVLSRALMYIPQLGKYAESI 2141

  Fly   231 VWWKTNSGQNRA----IIGYSDGSICFV------------------GLSPNCPMIASTAIENG-S 272
            :...::||:..|    |...:..::|.:                  |:|.:..::||...:.| :
Human  2142 LENGSSSGRKLAKLQRIARQAVAALCALGGFKETIKIGSEVQVLGRGISGSIGVVASINEQEGIA 2206

  Fly   273 VMRL--VICK--DKAYDGVMLLIT------SSLKQQYKLLLEQKAIKYVYPGDSSPTTREGAWQI 327
            .:|.  :.|:  .:|.|.:.:.::      |.....:||.:.:|.::.|   .|....:||:..|
Human  2207 TVRFPPIDCRKTSQASDTLTIPLSRLCVPRSEALPLHKLSITEKVVQAV---QSMLLPQEGSLSI 2268

  Fly   328 VMSVQDKHQSAATGARQSNSSDPA----------------------SDSSQLEEDVFAPPSSDDV 370
            ..|:      .|||    :.|.|.                      .||...||.:...|::.:|
Human  2269 HTSL------PATG----DGSAPVMAVVRLLAEIRTRACLVMAQLLEDSLFCEEFIQQCPAAVEV 2323

  Fly   371 V------CSGPGAANSDPSTVSASAEAAT---ADVPPPPAPPSYSEAVARQSGDQGGVRFQQQQL 426
            :      ||    |....:.|....|...   .|...||.||..::            |.|.:::
Human  2324 LNLVAQECS----AGERLAVVEVQCERLRMLYRDCARPPPPPLQAD------------RRQPKEI 2372

  Fly   427 PAGSMDGILPATRARLASLKSLGSKKLQAIKMRLSDQRQKFDEFMPDST------MGSFAIMDSP 485
             ..|...:.|..||      .:.|..|.::            .|:.|.:      .|:|....||
Human  2373 -TWSPSRVFPPVRA------CMFSSHLTSV------------TFLADPSAGGGLPRGTFIYATSP 2418

  Fly   486 ------------------------------SVTPE----------PLGTTSGSFYNIQNLRSTFL 510
                                          ..|.|          |:||.  .|:|  |.|
Human  2419 LPVQAPSFYWEIEIVSYGDTDDDTGPIVSFGFTTEAEKRDGAWTNPVGTC--LFHN--NGR---- 2475

  Fly   511 LSALHSNSHSLTVHS---IDISLKP--------------------------LFVY---KIPKHTQ 543
              |:|.|..||....   :|::|.|                          .|.|   ::..:.:
Human  2476 --AVHYNGSSLLQWKSVRLDVTLSPGDVAGIGWERTEGTPPPPGQPAKGRVYFTYCGQRLSPYLE 2538

  Fly   544 EILISSNILYGIHYVDLHCRSDSD-------------HFTAASLLDDPLVANTEKENRDADIEKV 595
            :  :|..:...:|....:.::.::             |..||.|..|      ..|...|:.|.:
Human  2539 D--VSGGMWPVVHIQKKNTKTRANFGSRPFAYAEGQAHRNAADLCTD------LAEEISANFEAL 2595

  Fly   596 DQSDVSAQKSDSTSATTTATSSLDQSDMPSTAINAVSVISSAMASLHTSDEDRFNNLAQLGLFRF 660
            .    .|..|||.:...|:.:|...:..|...|.||:....                      ::
Human  2596 P----FAMASDSDNDAGTSIASDPGTHGPPCRIAAVATAQQ----------------------QY 2634

  Fly   661 ENETVLHLYQMAQYRN-----PSAEPETLTKEEK-----------------AKAFELKDIHT--- 700
            :::|..|......|.|     |...|..:..:|.                 .||:|.|...|
Human  2635 DSDTSCHYKVELSYENFITSGPDPHPPPIADDESDDDDDDDIPQEDHYALLVKAWETKVFPTIRR 2699

  Fly   701 ----------PMDYIQ------------------FYETADVSSEFSLRQMEIMQSEFPKINYDP- 736
                      .:|.|:                  :.|...:..:..|..:|.::.|..|...|.
Human  2700 RFRNEAERKSGLDQIKGALQLGMVDIARQTVEFLYEENGGIPRDLYLPTIEDIKDEANKFTIDKV 2764

  Fly   737 ---SYVIT----NKNV-----------YTIQLKKEPFEL---FLDAALQNEFNQCRDFCNTFDLS 780
               ..|:|    :.||           :.|:...:.|.|   .||....||..|...:..:..:.
Human  2765 RKGLTVVTRSPDSNNVASSAVGTALPKFAIRGMLKTFGLHGVVLDVDSVNELVQVETYLRSEGVL 2829

  Fly   781 FEQCIEFAGDYLLR-----RKKITQALLTYNKARVKPIRTALK----LAMYGHTYALMQLSA--- 833
            ....  :..|.|.|     |:..|..|:|.:...::..|..|:    ||......||:.:.|
Human  2830 VRYW--YPIDMLERPPAGYRRTATNGLVTLDNTNLQIHRELLRCEAALARLYCRMALLNIFAPKL 2892

  Fly   834 ---------------MALKSTYLLRSRYLGHPLLKGILG----------------------DITY 861
                           :.|:...||.::.|..||..|.:.                      |:.|
Human  2893 PHLFTRLFHIPAIRDITLEHLQLLSNQLLAPPLPDGTISSSSILLAQSLQHCIHSQNCSATDLFY 2957

  Fly   862 R-HSEDVRVILPEKHEEEDVNSGVFCSDYHYGVDESI------------SALQMSPSSQFHLANL 913
            : :|:.||         |.:|..: ....|.| :||:            :|.:..||.:|
Human  2958 QGNSQTVR---------EWLNVAI-TRTLHQG-EESLLELTKQICSFLQTAPEQFPSEEF----- 3006

  Fly   914 LLITLAEKAVN-DKNYIPLWNFLVTNSK------------YHTNMTSIVLC----------QSGL 955
               .::|..|| |.|: |...|:|.:.|            |......:::.          |..|
Human  3007 ---PISESKVNMDVNF-PGAAFVVVSCKESQSGFRKDSSLYKAPWARVLVYGLGHKVKRNGQLNL 3067

  Fly   956 FSSA------------------------IILAKIR-----------GVCLD------TFNALISV 979
            ..:|                        ::|:..|           |..|.      .|...::.
Human  3068 IEAACYPRDASPANTGLAPPPTADQYPSVVLSTDRVHIKLGVSPPPGAVLVLHSLPLEFPLAMAF 3132

  Fly   980 VAQEFGWYNELNVCLYNLSE--------NIFLETITYLPHV--SMDYFAFIQEKLHHIRPCVLQR 1034
            ..|...|.:|.:   ...||        ::.|:.:..|.:.  :.|..|.::|.:.|:    |..
Human  3133 AEQLLSWKSEDS---EGKSEDEPDTIPTSVLLQVVELLGNFLWTTDMAACVKELVFHL----LAE 3190

  Fly  1035 LSKQLNPFSPALRPIVSHNSDCAMSNDNNPQLFEFCKSLIETYLAVLIHMESQRVK-YD-SIVNA 1097
            |.:.::.......| ...:|..|:  ..||     |       ||:|:.::|:..| || ...|.
Human  3191 LLRTVHTLEQRRHP-AGLSSSIAL--QLNP-----C-------LAMLMALQSELHKLYDEETQNW 3240

  Fly  1098 LSNFRINYEDNQFAIESSRFK----PISAGCAYCACVVDGTAYFWGSSGIPS----YYSAQKSTE 1154
            :|...........|.:..||.    .:..||...|.|...|.....:||:.|    ..|...|:.
Human  3241 VSGGACGGSGGAAAGDQGRFSTYFHALMEGCLAVAEVTLPTNMSVTASGVTSATAPNLSDSSSSS 3305

  Fly  1155 PPEPAHAVKSLDLLSQLN----LQVHAIKCGRQHT--LILTNNGLYSLGNNN----------LCQ 1203
            ...|....:|..|||:..    .:..|...|::.:  .:.::..:.|:|.:.          |..
Human  3306 SSSPGQTPQSPSLLSKRKKVKMKREKASSSGKRQSSRTVDSDPTVLSIGGSKPEDMLWFHRALTL 3370

  Fly  1204 LGIGRHMQMALQPMLVTALD--GMNITMLEAGQYHNAAVADGKLYMWGWGIYGQLGQGSCENIAT 1266
            |.|.||:         |..|  |:.:|        :.|:||                 :|:.:..
Human  3371 LIILRHL---------TRKDPQGLGVT--------SDAIAD-----------------ACQALVG 3401

  Fly  1267 PQLVSFFKFKKILQISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDT-K 1330
            |               ..|:..||:.|.| :|::      |..|.|:     :....:.||.. |
Human  3402 P---------------TAHSRLLVISGIP-THLD------EGVVRGA-----IRKACNAHGGVFK 3439

  Fly  1331 TNLPVRLEVGDCSLRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEENQQR 1395
            ..:.:.|:..|       ||                                 ..|.|.|....:
Human  3440 DEIYIPLQEED-------TK---------------------------------KPKDKAEGGDGK 3464

  Fly  1396 ELLSKQLEATLLPAPIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKDCQDVQNEAAPSDATETIA 1460
            ....|.|......:...|||:.:.|..|.:|  :.||.::|:..::            ..::|::
Human  3465 VEPEKTLAFPGTDSMEVSTSSSLTPAMSISA--SASTSQASICSSQ------------GISQTVS 3515

  Fly  1461 PASAKAAPPPVPVASPPVLVPEPDPTEHLTPHLVDTSEVAGRILQISSGLFHFCLISSSCTLYTW 1525
            ..|....|..:.:..||.|         |.||.|.:.|    .|.||     .|...|..:|.:.
Human  3516 DLSVDPLPAGLELPIPPGL---------LEPHAVSSQE----SLDIS-----LCSTGSLGSLGSL 3562

  Fly  1526 GKNLEHQLGTEDKDRRAVLKPSPIDSIERPMYVDCGSDFTL 1566
            |:                    |:|:.|.....|.||.:|:
Human  3563 GE--------------------PLDNAETASVSDMGSMYTV 3583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_733309.3	ATS1	1181..1587	CDD:444065	72/401 (18%)
HECTD4	NP_001103132.4	SPRY_HECT_like	2409..2564	CDD:293970	25/166 (15%)
		HECTc	4029..4423	CDD:238033