DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and Hectd4

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	XP_006530414.1	Gene:	Hectd4 / 269700	MGIID:	3647820	Length:	4525	Species:	Mus musculus

Alignment Length:	1847	Identity:	329/1847 - (17%)
Similarity:	561/1847 - (30%)	Gaps:	675/1847 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 SACSLYSTTQVTSYIIPFVGPH-ECPNSKKCPNHSTGLEESTAEPMDQLAENLEQARLQEGEEEE 174
            ||....:|....|.:|..|||. |..|.:.....|||.::.||:.......|.|.||      .:
Mouse  2119 SAALRKATKWAQSGLIVSVGPPVESINPETVSGLSTGDKKKTAQTSICRERNSELAR------TD 2177

  Fly   175 PLGHDLPEHMLVRNSGTEDAV--------QPLPQQQQTIDTTGNSQVMAASFMASKTCPYPLSVV 231
            |:...:..|  |.||...:.:        .|.....|...||....:..|.....:...|..|::
Mouse  2178 PVRPFISGH--VANSMAAEVIALLHSLLMAPESNAAQIWTTTAEKVLSRALMYIPQLGKYAESIL 2240

  Fly   232 WWKTNSGQNRA----IIGYSDGSICFV------------------GLSPNCPMIASTAIENG-SV 273
            ...::||:..|    |...:..::|.:                  |:|.:..::||...:.| :.
Mouse  2241 ENGSSSGRKLAKLQRIARQAVAALCALGGFKETIKIGSEVQVLGRGISGSIGVVASINEQEGIAT 2305

  Fly   274 MRL--VICK--DKAYDGVMLLIT------SSLKQQYKLLLEQKAIKYVYPGDSSPTTREGAWQIV 328
            :|.  |.|:  .:|.|.:.:.::      |.....:||.:.:|.::.|   .|....:||:..|.
Mouse  2306 VRFPPVDCRRTSQAADTLTIPLSRLCVPRSEALPLHKLSITEKVVQAV---QSMLLPQEGSLSIH 2367

  Fly   329 MSVQDKHQSAATGARQSNSSDPA----------------------SDSSQLEEDVFAPPSSDDVV 371
            .|:      .|||    :.|.|.                      .||...||.:...|::.:|:
Mouse  2368 TSL------PATG----DGSAPVMAVVRLLAEIRTRACLVMAQLLEDSLFCEEFIQQCPAAVEVL 2422

  Fly   372 ------CSGPGAANSDPSTVSASAEAAT---ADVPPPPAPPSYSEAVARQSGDQGGVRFQQQQLP 427
                  ||    |....:.|....|...   .|...||.||..::            |.|.:::
Mouse  2423 NLVAQECS----AGERLAVVEMQCERLRMLYRDCARPPPPPLQAD------------RRQPKEI- 2470

  Fly   428 AGSMDGILPATRARLASLKSLGSKKLQAIKMRLSDQRQKFDEFMPDSTMGSFAIMDSPSVTPEPL 492
            ..|...:.|..||      .:.|..|.::            .|:.|.:.|......:......||
Mouse  2471 TWSPSRVFPPVRA------CMFSSHLTSV------------TFLADPSAGGGLPRGTFIYATSPL 2517

  Fly   493 GTTSGSFY-NIQ-------------------------------NLRSTFLL----SALHSNSHSL 521
            ...:.||| .|:                               |...|.|.    .|:|.|..||
Mouse  2518 PVQAPSFYWEIEIVSYGDTDDDTGPIVSFGFATEAEKRDGAWTNPVGTCLFHNNGRAVHYNGSSL 2582

  Fly   522 TVHS---IDISLKP--------------------------LFVY---KIPKHTQEIL-------- 546
            ....   :|::|.|                          .|.|   ::..:.:::.
Mouse  2583 LQWKSVRLDVTLSPGDVAGIGWERTEGTPPPPGQPAKGRVYFTYCGQRLTPYLEDVSGGMWPVVH 2647

  Fly   547 ----------------------------------ISSNILYGIHYVDLHCRSDSDHFTAASLLDD 577
                                              ::..|......:.....||||:....|:..|
Mouse  2648 IQKKNTKTRANFGSRPFAYAEGQAHRNAADLCTDLAEEISANFEALPFAMASDSDNDAGTSIASD 2712

  Fly   578 P---------LVANTEKENRDADIE---KVDQS--------------DVSAQKSDSTSATTTATS 616
            |         ....|.::..|:|..   ||:.|              .::..:||..
Mouse  2713 PGTHGPPCRIAAVATAQQQYDSDTSCHYKVELSYENFITSGPDPHPPPIADDESDDD-------- 2769

  Fly   617 SLDQSDMPSTAINAVSVISSAMASLHTSDEDRFNNLA-------------QLGLFRFENETVLHL 668
              |..|:|.....|: ::.:....:..:...||.|.|             |||:.....:||..|
Mouse  2770 --DDDDIPQEDHYAL-LVKAWETKVFPTIRRRFRNEAERKSGLDQIKGALQLGMVDIARQTVEFL 2831

  Fly   669 YQMAQYRNPSAEPETLTKEEKAKAFELKDIHTPMDYIQFYETADVSSEFSL----RQMEIMQSEF 729
            |                 ||....  .:|::.|    ...:..|.:::|::    :.:.::....
Mouse  2832 Y-----------------EENGGI--PRDLYLP----TIEDIKDEANKFTIDKVRKGLTVVTRSP 2873

  Fly   730 PKINYDPSYVITNKNVYTIQLKKEPFEL---FLDAALQNEFNQCRDFCNTFDLSFEQCIEFAGDY 791
            ...|...|.|.|....:.|:...:.|.|   .||....||..|...:..:..:.....  :..|.
Mouse  2874 DSSNVASSTVGTALPKFAIRGMLKTFSLHGVVLDVDSVNELVQVETYLRSEGVLVRYW--YPIDM 2936

  Fly   792 LLR-----RKKITQALLTYNKARVKPIRTALK----LAMYGHTYALMQLSA-------------- 833
            |.|     |:..|..|:|.:...::..|..|:    ||......||:.:.|
Mouse  2937 LERPPAGYRRTATNGLVTLDNTNLQIHRELLRCEAALARLYCRMALLNIFAPKLPHLFTRLFHIP 3001

  Fly   834 ----MALKSTYLLRSRYLGHPLLKGILG----------------------DITYRHS-------- 864
                :.|:...||.::.|..||..|.:.                      |:.|:.|
Mouse  3002 AIRDITLEHLQLLSNQLLAPPLPDGTISSSSILLAQSLQHCIHSQSCSATDLFYQGSSQTLREWL 3066

  Fly   865 -----------EDVRVIL-----------PEKHEEE-----------DVNSG------VFCSDYH 890
                       ||..:.|           ||:...|           |||..      |.|.:..
Mouse  3067 SVAITRTLHQGEDSLLELTKQICAFLQTAPEQFPSEEFPVSESKVSMDVNFPGAAFVVVSCKESQ 3131

  Fly   891 YGVDESISALQMSPSSQFHLANLLLITLAEKA--VNDKNYIPLWNFLVTNSKYHTNMT------- 946
            .|..:. |:|..:|     .|.:|:..|..|.  ....|.|....:....|..:|.:.
Mouse  3132 SGFRKD-SSLYKAP-----WARVLVYGLGHKVKRTGQLNLIEAACYPRDASPANTGLAPPPTADQ 3190

  Fly   947 --SIVLCQSGLF--------SSAIILAKIRGVCLDTFNALISVVAQEFGWYNELNVCLYNLSE-- 999
              |:||....:.        ..|:::  :..:.|: |...::...|...|.:|.:   ...||
Mouse  3191 YPSVVLSTDKVHIKLGVSPPPGAVLV--LHSLPLE-FPLAMAFAEQLLSWKSEDS---DGKSEDE 3249

  Fly  1000 ------NIFLETITYLPHV--SMDYFAFIQEKLHHIRPCVLQRLSKQLNPFSPALRPIVSHNSDC 1056
                  ::.|..:..|.:.  :.|..|.::|.:.|:    |..|.:.::.......| ...:|..
Mouse  3250 PDSIPASVLLHVVELLGNFLWTTDMAACVKELVFHL----LAELLRTVHTLEQRKHP-AGLSSSI 3309

  Fly  1057 AMSNDNNPQLFEFCKSLIETYLAVLIHMESQRVK-YDSIVNALSNFRINYEDNQFAIESSR---- 1116
            |:  ..||     |       ||:|:.::|:..| ||             |:.|..:.||.
Mouse  3310 AL--QLNP-----C-------LAMLMALQSELHKLYD-------------EETQSWVSSSACGGS 3347

  Fly  1117 --------------FKPISAGCAYCACVVDGTAYFWGSSGIPS----YYSAQKSTEPPEPAHAVK 1163
                          |..:..||...|.|...|.....:||:.|    ..|...|:....|....:
Mouse  3348 GAAAVGDQGRFSTYFHALMEGCLAVAEVTLPTNISVTASGVTSTTTPNLSDSSSSSSSSPGQTPQ 3412

  Fly  1164 SLDLLSQLNLQVHAIKCGRQHTLILTNNGLYSLGNNNLCQLGIGR---------HMQMALQPML- 1218
            |..|||:..    .:|..|:..............:.:...|.||.         |..:.|..:|
Mouse  3413 SPSLLSKRK----KVKMKREKASSSNKRQSSRASDADSTVLSIGGSKPEDMLWFHRALTLLIILR 3473

  Fly  1219 -VTALD--GMNITMLEAGQYHNAAVADGKLYMWGWGIYGQLGQGSCENIATPQLVSFFKFKKILQ 1280
             :|..|  |:.:|        :.|:||                 :|:.:..|
Mouse  3474 HLTKKDPQGLGVT--------SDAIAD-----------------ACQALVGP------------- 3500

  Fly  1281 ISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDT-KTNLPVRLEVGDCSL 1344
              ..|:..||:.|.| :|::      |..|.|:     :....:.||.. |..:.:.|:
Mouse  3501 --TAHSRLLVISGIP-THLD------EAVVRGA-----IRKACNAHGGVFKDEIYIPLQ------ 3545

  Fly  1345 RLIHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEENQQRELLSKQLEATLLPA 1409
                         ||..:                     ..|.|.|.:..:....|.|....:.:
Mouse  3546 -------------DEDPK---------------------KPKDKAEGSDSKVESEKLLGFPSVDS 3576

  Fly  1410 PIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKDCQDVQNEAAPSDATETIAPASAKAAPPPVPVA 1474
            ...|||:.:.|..|.:|  :.||.::||..:: |           .::|.:..|....|..:.:.
Mouse  3577 LEGSTSSSLAPAMSISA--SASTSQASVCSSQ-C-----------VSQTASDLSVDPLPSGLELP 3627

  Fly  1475 SPPVLVPEPDPTEHLTPHLVDTSEVAGRILQISSGLFHFCLISSSCTLYTWGKNLEHQLGTEDKD 1539
            .||||         |.||:|.:.|    .|.||     .|...|..:|.:.|:
Mouse  3628 VPPVL---------LEPHVVSSQE----SLDIS-----LCSTGSLGSLGSLGE------------ 3662

  Fly  1540 RRAVLKPSPIDSIERPMYVDCGSDFTL 1566
                    |:|:.|.....|.||.:|:
Mouse  3663 --------PLDNPETASVSDVGSMYTV 3681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	79/423 (19%)
		RCC1_2	1175..1200	CDD:290274	2/24 (8%)
		RCC1	1193..1240	CDD:278826	10/59 (17%)
		RCC1	1242..1291	CDD:278826	5/48 (10%)
		RCC1_2	1503..1532	CDD:290274	7/28 (25%)
		RCC1	1522..1568	CDD:278826	9/45 (20%)
		RCC1_2	1558..1584	CDD:290274	4/9 (44%)
Hectd4	XP_006530414.1	CCDC154	149..>233	CDD:373856
		SPRY_HECT_like	2507..2662	CDD:293970	19/154 (12%)
		HECTc	4127..4520	CDD:391658
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900