DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and HERC4

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	XP_011537894.1	Gene:	HERC4 / 26091	HGNCID:	24521	Length:	1081	Species:	Homo sapiens

Alignment Length:	907	Identity:	182/907 - (20%)
Similarity:	285/907 - (31%)	Gaps:	367/907 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1171 LNLQVHAIKCGRQHTLILTNNG-LYSLGNNNLCQLGIGRHMQMALQPMLVTALDGMNITMLEAGQ 1234
            :|.:|..:.||.:||:.:.::| :|:.|.|:|.|||   |.:...:|..|.|||..||..:..|:
Human    32 INKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG---HEKSRKKPEQVVALDAQNIVAVSCGE 93

  Fly  1235 YHNAAVAD-GKLYMWGWGIYGQLG-QGSCENIATPQL----------------VSFFKFK----- 1276
            .|..|:.| |::|.||....|||| .||.|.|..|..                :|:.:.:
Human    94 AHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPSCFPKIMCVDSLVRICSGLSYGRIRNIKSL 158

  Fly  1277 ---KILQISLGHAHTLVLCGAPNSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTKTNLPVRLE 1338
               :|:|::.|:.|:|.|..|           :|:|.:|.|.:||||.|.
Human   159 SDIQIVQVACGYYHSLALSKA-----------SEVFCWGQNKYGQLGLGT--------------- 197

  Fly  1339 VGDCSLRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEENQQRELLSKQLE 1403
              ||..:                      :|||.|:
Human   198 --DCKKQ----------------------TSPQLLK----------------------------- 209

  Fly  1404 ATLLPAPIPSTSTLVEPTTSYAAVVAGSTPKSSVSDTKDCQDVQNEAAPSDATETIAPASAKAAP 1468
             :||..|
Human   210 -SLLGIP---------------------------------------------------------- 215

  Fly  1469 PPVPVASPPVLVPEPDPTEHLTPHLVDTSEVAGRILQISSGLFHFCLISSSCTLYTWGKNLEHQL 1533
                                              .:|:::|..|..:::.|..::.||:|...||
Human   216 ----------------------------------FMQVAAGGAHSFVLTLSGAIFGWGRNKFGQL 246

  Fly  1534 GTEDKDRRAVLKPSPIDSI--ERPMYVDCGSDFTLVMTTDHVVRAFGGNSNGQCGRDLGPSVERM 1596
            |..|::.|.|  |:.:.|:  ::.:|:.||.|.|..:|.:..|..||....||.|.:
Human   247 GLNDENDRYV--PNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN-------- 301

  Fly  1597 RQRVVCLPATKRLVRFESQCVEVPVEINLPRPRIRLDQDPVRYLKVMPPYQPHFLQPAN--ISF- 1658
                    :|..             ||| ||....|....|..:.....:...|:..:.  .||
Human   302 --------STSH-------------EIN-PRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 344

  Fly  1659 ----DQHCSVGTPNYKS-----STEHAATGQ-----DSDDMLSSLENLSQNDASFSYNAPVLGDA 1709
                .|..:..|.|.||     ...:...||     ||::........|..|.|||
Human   345 LGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEEYFCVKRIFSGGDQSFS--------- 400

  Fly  1710 HSSLDMDYTPEEQSYVPLPEQAVGSGMPANAEQLL----GR------DDDDGSTYTQSTEGMGES 1764
            |.|...:..|.:....|.|.:.:.:...|..::.|    ||      ::.||   |.|:.|....
Human   401 HYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDG---TFSSSGCLNG 462

  Fly  1765 SLQHLRHYIHY-------------CLYAFHGLYNPD--KIGECARPHRNEYRIRICMLNFRFVEA 1814
            |...:.:..||             ....||.|..||  :|.:.......:..|.....:...|||
Human   463 SFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEA 527

  Fly  1815 FR--LCLQSC----------------GSA-----QRTLKLFE---------YFSKDTGYVPLRRT 1847
            .|  |.|..|                |:|     :..||:.|         .|.|   .|.|.:.
Human   528 LRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLENWWSVLEPPLFLK---IVELFKE 589

  Fly  1848 DLKHL--------------IYHLCLHFLERKFDMLECERFFMGDL----DYYLLELAYVFYFNNN 1894
            .:.||              |::..||...:..::|......||.:    .:|:.|:..:....|:
Human   590 VVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKMGQIIQYDKFYIHEVQELIDIRND 654

  Fly  1895 NSTLEQNLNQKFKQLIAAADSNQAATSAGQELEQLQDTDV-------IFDSFTVKFKTILCQ 1949
            .....|       |.....|.|...|       :|.|..|       :||:   :.||.|.|
Human   655 YINWVQ-------QQAYGMDVNHGLT-------ELADIPVTICTYPFVFDA---QAKTTLLQ 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	92/445 (21%)
		RCC1_2	1175..1200	CDD:290274	8/25 (32%)
		RCC1	1193..1240	CDD:278826	17/46 (37%)
		RCC1	1242..1291	CDD:278826	20/74 (27%)
		RCC1_2	1503..1532	CDD:290274	7/28 (25%)
		RCC1	1522..1568	CDD:278826	16/47 (34%)
		RCC1_2	1558..1584	CDD:290274	8/25 (32%)
HERC4	XP_011537894.1	RCC1	2..368	CDD:332518	108/542 (20%)
HERC4	XP_011537894.1	HECTc	733..1079	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920