DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and ZZEF1

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	XP_016879871.1	Gene:	ZZEF1 / 23140	HGNCID:	29027	Length:	2966	Species:	Homo sapiens

Alignment Length:	1214	Identity:	237/1214 - (19%)
Similarity:	389/1214 - (32%)	Gaps:	407/1214 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 YSDGSICFVGLSPNCPMIA-STAIENGSVMRLVICKDKAYDGVMLLITSSLKQQYKLLLEQKAIK 309
            ||:   .|.|....|...| .|.|..||.:      |:|.:.....:.......|     :|..|
Human  1308 YSE---LFKGFIQACRKQAPKTDIVAGSTI------DQAVNATFAALVYRTPDLY-----EKLQK 1358

  Fly   310 YVYPGDSSPTTREGA-----------WQIVM----------SVQDKHQSAATGARQSNSSDPASD 353
            ||..|.....:.|.|           |.:.|          ..::||.|.||.....:.:....:
Human  1359 YVNSGGKIALSEEFAQVYSLADGIRIWMLEMKQKSLMSLGNEAEEKHSSEATEVNPESLAKECIE 1423

  Fly   354 SSQL-----------EEDVFAPPSSDDVVCSGPGAANSDPSTVSASAEAATADV-PPPPAPPSYS 406
            .|.|           :|......::|:.....|  .|....|.|...|...|.| |...|||:
Human  1424 KSLLLLKFLPTGISSKESCEKLETADETSHLQP--LNKRQRTSSVVEEHFQASVSPTEAAPPA-- 1484

  Fly   407 EAVARQSGDQGGVRFQQQQLPAGS---MDGILPAT-------------------RARLASLKSLG 449
                  :|||......|.:||:.|   ...:.|||                   |.||.|.:|:.
Human  1485 ------TGDQSPGLGTQPKLPSSSGLPAADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSME 1543

  Fly   450 SKKL-QAIKMRLSDQRQKFDEFMPDSTMGSFAIMDSPSVTPEPLGTTSGSFYNIQNLRSTFLLSA 513
            ..:| ..:|.:....:...| |:.|.::...:::.                          :||.
Human  1544 EARLVPTVKEKYPVLKDVMD-FIKDQSLSHRSVVK--------------------------VLSL 1581

  Fly   514 LHSNSHSLTVHSIDISLKPLFVYKIPKHTQEILISSN------ILYGIHYVDLHCRSDSDHFTAA 572
            ..:.:.|:           |.|.||.:|..|.|...:      ||:.:..  |.|:.|..::...
Human  1582 RKAQAQSI-----------LEVLKITQHCAESLGQPHCFHPPFILFLLEL--LTCQKDFTNYFGH 1633

  Fly   573 SLLDDPLVANTEKENRDADIEKVDQSDVSAQKSDSTSATTTATSSLDQSDMPSTAINAVSVISSA 637
            .   :...|:..||.||...:.| ...|.|.|..|        |..|:|.:|     |:|.:.:|
Human  1634 L---EGCGADLHKEIRDTYYQLV-LFLVKAVKGFS--------SLNDRSLLP-----ALSCVQTA 1681

  Fly   638 MASLHTSDED-RFNNLAQLGLFRFENETVLHLYQMAQYRNPSAEPETLTK-EEKAKAFELKDIHT 700
            :  ||..|.. ..|:||    |..:.:....|.:|:| .|.|.....::: .|:.:..:.|....
Human  1682 L--LHLLDMGWEPNDLA----FFVDIQLPDLLMKMSQ-ENISVHDSVISQWSEEDELADAKQNSE 1739

  Fly   701 PMDYIQ------FYETADVSSEFSLRQMEIMQSEF-----PKINYDPSYVITNKNVYTIQLKKEP 754
            .||..|      :||..........|:|.:..:.:     ..|:.|....|...:.|.. |:...
Human  1740 WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVDISCDGCDEIAPWHRYRC-LQCSD 1803

  Fly   755 FEL----FL----------DAALQN-EF--NQCR----------DFCNTFDLSFEQCIEFAGDYL 792
            .:|    ||          |..:.| ||  :.|:          :.|:.|||.:       |.|
Human  1804 MDLCKTCFLGGVKPEGHGDDHEMVNMEFTCDHCQGLIIGRRMNCNVCDDFDLCY-------GCY- 1860

  Fly   793 LRRKKITQALLTYNKARVKPIRTALKLA-------MYGHTYALMQLSAMALKSTYL--------- 841
             ..||.:...|..:.....|:.| ::::       .|.|.|:.:..:|:||.|.:|
Human  1861 -AAKKYSYGHLPTHSITAHPMVT-IRISDRQRLIQPYIHNYSWLLFAALALYSAHLASAEDVDGE 1923

  Fly   842 ------------LRS---RYLGHPLLK-------------GIL--GDITYRHSEDVRVILPEKHE 876
                        |||   :.:|..|:|             |:|  ||.:. ..:.:.|.:|....
Human  1924 KLDPQTRSSATTLRSQCMQLVGDCLMKAHQGKGLKALALLGVLPDGDSSL-EDQALPVTVPTGAS 1987

  Fly   877 EEDVN----SGVFCSDYHYG------------------VDESISALQMSPSSQFHLANLLLIT-- 917
            ||.:.    .|...|:...|                  .|:.:| |...||.|..:::.....
Human  1988 EEQLEKKAVQGAELSEAGNGKRAVHEEIRPVDFKQRNKADKGVS-LSKDPSCQTQISDSPADASP 2051

  Fly   918 -----------------LAEKAVND------------------------------------KNYI 929
                             :.||||..                                    ::.:
Human  2052 PTGLPDAEDSEVSSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGPTVPLIDLEHVL 2116

  Fly   930 PLWNFLVTNSKYHTNMT-SIVLCQSGLFSSAII----------LAKIRGVCLDTFNALISVVAQE 983
            ||...:|.::..|.|.| .:.|   ||....||          :.|:.....:.|.|..|.:..:
Human  2117 PLMFQVVISNAGHLNETYHLTL---GLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDSSIVPD 2178

  Fly   984 FGWYNELNVCLYNLSENIFLETITYLPHVSMDYFAFIQEKLHHIRPCVLQR---------LSKQL 1039
             ||  :....|::|.. :.|::     .|.:|:...:.|.|..:....|.|         ..|||
Human  2179 -GW--KTTHLLFSLGA-VCLDS-----RVGLDWACSMAEILRSLNSAPLWRDVIATFTDHCIKQL 2234

  Fly  1040 NPFS------------PALRPIVSHNSDCA-MSNDNNPQLFEFCKSLIETYLAVLIHMESQR--- 1088
             ||.            .....::...:.|. |.|.|.|......|...|...||::.:::::
Human  2235 -PFQLKHTNIFTLLVLVGFPQVLCVGTRCVYMDNANEPHNVIILKHFTEKNRAVIVDVKTRKRKT 2298

  Fly  1089 VKYDSIVN-------ALSNFRINYEDNQFAIESSRFKPISAGCAYCACVVDGTAYFWG-SSGIPS 1145
            ||...:|.       ..|..:::.....||..:|.....|.. ::|...|:.|   |. |..:..
Human  2299 VKDYQLVQKGGGQECGDSRAQLSQYSQHFAFIASHLLQSSMD-SHCPEAVEAT---WVLSLALKG 2359

  Fly  1146 YYSAQKSTEPPEPAHAVKSL-------DLLSQLNLQVHAIKCGR 1182
            .|...|       ||..:.:       |||..|     ..||.:
Human  2360 LYKTLK-------AHGFEEIRATFLQTDLLKLL-----VKKCSK 2391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	8/32 (25%)
		RCC1_2	1175..1200	CDD:290274	2/8 (25%)
		RCC1	1193..1240	CDD:278826
		RCC1	1242..1291	CDD:278826
		RCC1_2	1503..1532	CDD:290274
		RCC1	1522..1568	CDD:278826
		RCC1_2	1558..1584	CDD:290274
ZZEF1	XP_016879871.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900