Protein Alignment ca and ZZEF1

DIOPT Version :10

• Sequence 1: NP_733309.3
• Gene: ca / 43518
• FlyBaseID: FBgn0000247
• Length: 1961
• Species: Drosophila melanogaster
• Sequence 2: XP_016879871.1
• Gene: ZZEF1 / 23140
• HGNCID: 29027
• Length: 2966
• Species: Homo sapiens
• Alignment Length: 1214
• Identity: 237/1214 - (19%)
• Similarity: 389/1214 - (32%)
• Gaps: 407/1214 - (33%)

  Fly   246 YSDGSICFVGLSPNCPMIA-STAIENGSVMRLVICKDKAYDGVMLLITSSLKQQYKLLLEQKAIK 309
            ||:   .|.|....|...| .|.|..||.:      |:|.:.....:.......|     :|..|
Human  1308 YSE---LFKGFIQACRKQAPKTDIVAGSTI------DQAVNATFAALVYRTPDLY-----EKLQK 1358

  Fly   310 YVYPGDSSPTTREGA-----------WQIVM----------SVQDKHQSAATGARQSNSSDPASD 353
            ||..|.....:.|.|           |.:.|          ..::||.|.||.....:.:....:
Human  1359 YVNSGGKIALSEEFAQVYSLADGIRIWMLEMKQKSLMSLGNEAEEKHSSEATEVNPESLAKECIE 1423

  Fly   354 SSQL-----------EEDVFAPPSSDDVVCSGPGAANSDPSTVSASAEAATADV-PPPPAPPSYS 406
            .|.|           :|......::|:.....|  .|....|.|...|...|.| |...|||:
Human  1424 KSLLLLKFLPTGISSKESCEKLETADETSHLQP--LNKRQRTSSVVEEHFQASVSPTEAAPPA-- 1484

  Fly   407 EAVARQSGDQGGVRFQQQQLPAGS---MDGILPAT-------------------RARLASLKSLG 449
                  :|||......|.:||:.|   ...:.|||                   |.||.|.:|:.
Human  1485 ------TGDQSPGLGTQPKLPSSSGLPAADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSME 1543

  Fly   450 SKKL-QAIKMRLSDQRQKFDEFMPDSTMGSFAIMDSPSVTPEPLGTTSGSFYNIQNLRSTFLLSA 513
            ..:| ..:|.:....:...| |:.|.::...:::.                          :||.
Human  1544 EARLVPTVKEKYPVLKDVMD-FIKDQSLSHRSVVK--------------------------VLSL 1581

  Fly   514 LHSNSHSLTVHSIDISLKPLFVYKIPKHTQEILISSN------ILYGIHYVDLHCRSDSDHFTAA 572
            ..:.:.|:           |.|.||.:|..|.|...:      ||:.:..  |.|:.|..::...
Human  1582 RKAQAQSI-----------LEVLKITQHCAESLGQPHCFHPPFILFLLEL--LTCQKDFTNYFGH 1633

  Fly   573 SLLDDPLVANTEKENRDADIEKVDQSDVSAQKSDSTSATTTATSSLDQSDMPSTAINAVSVISSA 637
            .   :...|:..||.||...:.| ...|.|.|..|        |..|:|.:|     |:|.:.:|
Human  1634 L---EGCGADLHKEIRDTYYQLV-LFLVKAVKGFS--------SLNDRSLLP-----ALSCVQTA 1681

  Fly   638 MASLHTSDED-RFNNLAQLGLFRFENETVLHLYQMAQYRNPSAEPETLTK-EEKAKAFELKDIHT 700
            :  ||..|.. ..|:||    |..:.:....|.:|:| .|.|.....::: .|:.:..:.|....
Human  1682 L--LHLLDMGWEPNDLA----FFVDIQLPDLLMKMSQ-ENISVHDSVISQWSEEDELADAKQNSE 1739

  Fly   701 PMDYIQ------FYETADVSSEFSLRQMEIMQSEF-----PKINYDPSYVITNKNVYTIQLKKEP 754
            .||..|      :||..........|:|.:..:.:     ..|:.|....|...:.|.. |:...
Human  1740 WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVDISCDGCDEIAPWHRYRC-LQCSD 1803

  Fly   755 FEL----FL----------DAALQN-EF--NQCR----------DFCNTFDLSFEQCIEFAGDYL 792
            .:|    ||          |..:.| ||  :.|:          :.|:.|||.:       |.|
Human  1804 MDLCKTCFLGGVKPEGHGDDHEMVNMEFTCDHCQGLIIGRRMNCNVCDDFDLCY-------GCY- 1860

  Fly   793 LRRKKITQALLTYNKARVKPIRTALKLA-------MYGHTYALMQLSAMALKSTYL--------- 841
             ..||.:...|..:.....|:.| ::::       .|.|.|:.:..:|:||.|.:|
Human  1861 -AAKKYSYGHLPTHSITAHPMVT-IRISDRQRLIQPYIHNYSWLLFAALALYSAHLASAEDVDGE 1923

  Fly   842 ------------LRS---RYLGHPLLK-------------GIL--GDITYRHSEDVRVILPEKHE 876
                        |||   :.:|..|:|             |:|  ||.:. ..:.:.|.:|....
Human  1924 KLDPQTRSSATTLRSQCMQLVGDCLMKAHQGKGLKALALLGVLPDGDSSL-EDQALPVTVPTGAS 1987

  Fly   877 EEDVN----SGVFCSDYHYG------------------VDESISALQMSPSSQFHLANLLLIT-- 917
            ||.:.    .|...|:...|                  .|:.:| |...||.|..:::.....
Human  1988 EEQLEKKAVQGAELSEAGNGKRAVHEEIRPVDFKQRNKADKGVS-LSKDPSCQTQISDSPADASP 2051

  Fly   918 -----------------LAEKAVND------------------------------------KNYI 929
                             :.||||..                                    ::.:
Human  2052 PTGLPDAEDSEVSSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGPTVPLIDLEHVL 2116

  Fly   930 PLWNFLVTNSKYHTNMT-SIVLCQSGLFSSAII----------LAKIRGVCLDTFNALISVVAQE 983
            ||...:|.::..|.|.| .:.|   ||....||          :.|:.....:.|.|..|.:..:
Human  2117 PLMFQVVISNAGHLNETYHLTL---GLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDSSIVPD 2178

  Fly   984 FGWYNELNVCLYNLSENIFLETITYLPHVSMDYFAFIQEKLHHIRPCVLQR---------LSKQL 1039
             ||  :....|::|.. :.|::     .|.:|:...:.|.|..:....|.|         ..|||
Human  2179 -GW--KTTHLLFSLGA-VCLDS-----RVGLDWACSMAEILRSLNSAPLWRDVIATFTDHCIKQL 2234

  Fly  1040 NPFS------------PALRPIVSHNSDCA-MSNDNNPQLFEFCKSLIETYLAVLIHMESQR--- 1088
             ||.            .....::...:.|. |.|.|.|......|...|...||::.:::::
Human  2235 -PFQLKHTNIFTLLVLVGFPQVLCVGTRCVYMDNANEPHNVIILKHFTEKNRAVIVDVKTRKRKT 2298

  Fly  1089 VKYDSIVN-------ALSNFRINYEDNQFAIESSRFKPISAGCAYCACVVDGTAYFWG-SSGIPS 1145
            ||...:|.       ..|..:::.....||..:|.....|.. ::|...|:.|   |. |..:..
Human  2299 VKDYQLVQKGGGQECGDSRAQLSQYSQHFAFIASHLLQSSMD-SHCPEAVEAT---WVLSLALKG 2359

  Fly  1146 YYSAQKSTEPPEPAHAVKSL-------DLLSQLNLQVHAIKCGR 1182
            .|...|       ||..:.:       |||..|     ..||.:
Human  2360 LYKTLK-------AHGFEEIRATFLQTDLLKLL-----VKKCSK 2391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_733309.3	ATS1	1181..1587	CDD:444065	0/2 (0%)
ZZEF1	XP_016879871.1	FRQ1	<95..141	CDD:444056
		APC10-ZZEF1	251..380	CDD:176488
		CUB	<1120..1190	CDD:412131
		ZZ_EF	1782..1829	CDD:239083	9/47 (19%)
		ZZ	1831..1878	CDD:239069	11/55 (20%)