DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and Nek9

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	NP_660120.2	Gene:	Nek9 / 217718	MGIID:	2387995	Length:	984	Species:	Mus musculus

Alignment Length:	994	Identity:	189/994 - (19%)
Similarity:	311/994 - (31%)	Gaps:	338/994 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   845 RYLGHPLLKGILGDIT-YRHSEDVRVI---------LPEKHEEEDVNSGV---------FCSDYH 890
            |.||    :|..|:.| ||.:||..::         |.||...:.:|..|         ..:.|:
Mouse    56 RVLG----RGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYN 116

  Fly   891 YGVDESISALQMSPSSQFHLANLLLITLAEKAVNDKNY---IPLWNFLVTNSKYHTNMTSIVLCQ 952
            :.:|.:...:::...:..:|.:.:|      ...||.:   :.:|        |...:.|.|.|
Mouse   117 HFMDNTTLLIELEYCNGGNLYDKIL------RQKDKLFEEEMVVW--------YLFQIVSAVSC- 166

  Fly   953 SGLFSSAIILAKIRGVCLDTFNALIS----VVAQEFGWYNELNVCLYNLSENIFLETITYLPHVS 1013
              :..:.|:...|:     |.|..::    :...::|...:||      ||....||:...|:
Mouse   167 --IHKAGILHRDIK-----TLNIFLTKANLIKLGDYGLAKKLN------SEYSMAETLVGTPY-- 216

  Fly  1014 MDYFA--FIQEKLHHIRP------CV------LQRLSKQLNPFSPALRPIVSHNSDCAMSNDNNP 1064
              |.:  ..|...::.:.      ||      |:|.....||.:..::.:....   ||..|::
Mouse   217 --YMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIR---AMEVDSS- 275

  Fly  1065 QLFEFCKSLIETYLAVLIHMESQRVKYDSIVN--ALSNFRINYEDNQFAIESSRFKPISAGC--A 1125
               ::...||:...|.|.....||...|::::  .|...|...|:....:.:...:|.|:..  |
Mouse   276 ---QYSLELIQLVHACLDQDPEQRPAADALLDLPLLRTRRREMEEKVTLLNAPTKRPRSSTVTEA 337

  Fly  1126 YCACVVDGTA--YFWGSSGIPSYYSAQKSTEPPEPAHAVKS--------------------LDLL 1168
            ..|.|...|:  |.||..         |||  |:....:||                    .:|.
Mouse   338 PIAVVTSRTSEVYVWGGG---------KST--PQKLDVIKSGCSARQVCAGNTHFAVVTVEKELY 391

  Fly  1169 SQLNLQ------------------------------VHAIKCGRQHTLILTNNG-LYSLGNNNLC 1202
            :.:|:|                              :|.:.||...|:.:|:.| ||:.|::...
Mouse   392 TWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYG 456

  Fly  1203 QLGIGR-HMQMALQPMLVTALDGMNITMLEAGQYHNAAVADGK-LYMWGWGIYGQLGQGSCENIA 1265
            .:|:.: .....|:||.:.......:..:..|..|...:...| :|.||.|.||:||..|.|:..
Mouse   457 CMGVDKVSGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYY 521

  Fly  1266 TPQLVSFFKFKKILQISLGHAHTLVL--------CG----------------------------- 1293
            |||.|...|...|:.:..|...|.:|        ||
Mouse   522 TPQRVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTT 586

  Fly  1294 ----------------AP-NSHMEANHCGNELFVFGSNHFGQLGTGNSDHGDTKTNLPVRLEVGD 1341
                            || .:|..|......|..||.|..||||.||     .|..|.:.|..|.
Mouse   587 SFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGN-----YKKRLGINLLGGP 646

  Fly  1342 CS----LRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRANAKQKMEE---------NQ 1393
            ..    :|:.....||..|.|: :.:|.||:.... |||.....|.:.......         :.
Mouse   647 LGGKQVIRVSCGDEFTIAATDD-NHIFAWGNGGNG-RLAMTPTERPHGSDICTSWPRPIFGSLHH 709

  Fly  1394 QRELLSKQLEATLLPAPIPSTSTLVEPTT--SYAAVVAGSTPKSSV-----------SDTKDCQD 1445
            ..:|..:.....|:...:.::.|:...::  |...||..|:|...:           .:.:|.|.
Mouse   710 VPDLSCRGWHTILIVEKVLNSKTIRSNSSGLSIGTVVQSSSPGGGIGGGGGGGGGGGGEEEDSQQ 774

  Fly  1446 VQNEAAPS-----------------DATETI------------------------------APAS 1463
            ......||                 ..||.:                              ||.|
Mouse   775 ESETPDPSGGFRGTMEADRGMEGLISPTEAVGNSCGASSSCPGWLRKELENAEFIPMPDSPAPLS 839

  Fly  1464 A------------------KAAP--PPVPVASPPVLVPEPDPTEHLTPHLVDTSEVAGRILQIS- 1507
            |                  |.|.  ||.|..:.....|..||........:.::..|...||:.
Mouse   840 AAFSQSEKDTLPYEELQGLKVASEVPPEPQRAAGAWPPRLDPAVPCVGKALTSAACACSALQVEV 904

  Fly  1508 ---SGLFHFCL----------ISSSCTLYTWGKNLE-------HQLGTEDKDRRAVLKPSPIDSI 1552
               ..|...||          :.....|....|.||       |..||:.......:.|.|
Mouse   905 DRLQALVLKCLEEQQKLQQENLQMFTQLQKLNKKLEGGQQVGMHSRGTQTAKEEMEMDPKP---- 965

  Fly  1553 ERPMYVDCGSDFTLVMTTD 1571
                  |..|:...::.||
Mouse   966 ------DLDSESWCLLGTD 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	117/635 (18%)
		RCC1_2	1175..1200	CDD:290274	9/25 (36%)
		RCC1	1193..1240	CDD:278826	9/47 (19%)
		RCC1	1242..1291	CDD:278826	19/49 (39%)
		RCC1_2	1503..1532	CDD:290274	9/49 (18%)
		RCC1	1522..1568	CDD:278826	11/52 (21%)
		RCC1_2	1558..1584	CDD:290274	4/14 (29%)
Nek9	NP_660120.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..43
		STKc_Nek9	51..296	CDD:270860	53/282 (19%)
		S_TKc	52..296	CDD:214567	53/282 (19%)
		RCC1 1	388..444		8/55 (15%)
		RCC1	389..441	CDD:278826	7/51 (14%)
		RCC1	444..495	CDD:278826	10/50 (20%)
		RCC1 2	445..498		10/52 (19%)
		RCC1 3	499..550		20/50 (40%)
		RCC1	500..547	CDD:278826	18/46 (39%)
		RCC1 4	551..615		6/63 (10%)
		RCC1 5	616..668		18/56 (32%)
		RCC1	616..664	CDD:278826	17/52 (33%)
		RCC1 6	669..726		9/57 (16%)
		Interaction with NEK6. /evidence=ECO:0000250	732..896		24/163 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..790		8/45 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..984		10/49 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910