DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ca and Rpgr

DIOPT Version :9

Sequence 1:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster
Sequence 2:	NP_001171421.1	Gene:	Rpgr / 19893	MGIID:	1344037	Length:	1039	Species:	Mus musculus

Alignment Length:	822	Identity:	174/822 - (21%)
Similarity:	277/822 - (33%)	Gaps:	257/822 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1120 ISAGCAYCACVVDGTAYF------WGSSGIPSYYSAQKSTEPPEPAHAVKSLDLLSQLNLQVHAI 1178
            :|.|..:.|.|......:      ||..|:.|..:..|.|       .:|:|.     ..:|...
Mouse    78 LSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPT-------CIKALK-----PEKVKLA 130

  Fly  1179 KCGRQHTLILTN-NGLYSLGNNNLCQLGIGR-------HMQMALQPMLVTALDGMNITMLEAGQY 1235
            .|||.|||:.|: .|:|:.|.||..|||:|.       |     |.:..|..|  .|..|.||..
Mouse   131 ACGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFH-----QIVFFTPAD--TIKQLSAGAN 188

  Fly  1236 HNAAVA-DGKLYMWGWGIYGQLGQGSCENIATPQLVSFFKFKKILQISLGHAHTLVL-------- 1291
            .:||:. ||||:|||....||:|.....|:..|..|:.  .|.|..||.|:.|:..:
Mouse   189 TSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEVTV--GKPISWISCGYYHSAFVTMDGELYT 251

  Fly  1292 --------CGAPNSHMEANH-----------------CG---------NELFVFGSNHFGQLGTG 1322
                    .|.|| .:..||                 ||         ..::.||...|||||.|
Mouse   252 FGEPENGKLGLPN-ELLMNHRSPQRVLGIPERVIQVACGGGHTVVLTEKVVYAFGLGQFGQLGLG 315

  Fly  1323 NSDHGDTKTNLPVRL---EVGDCSLRLIHTKFFTNLAVDEQDRLFTWGSSPQALRLANQIKRRAN 1384
            ......::..:..|:   ::...|....||...|.|.:     |:|:|..           |...
Mouse   316 TFLFETSEPKIIERIKDQKICHISCGENHTALMTELGL-----LYTFGDG-----------RHGK 364

  Fly  1385 AKQKMEE--NQQRELL-------SKQLEAT----LLPAPIPSTSTLVEP-----------TTSYA 1425
            ....||.  ||....|       :.||.|.    :|....|...|:.||           |.|::
Mouse   365 LGLGMENFTNQFFPTLCSNFLRFAVQLIACGGCHMLVFATPRLGTIDEPKFEDVYEPYISTGSFS 429

  Fly  1426 AVVAGSTPKSSVSDTKDC--QDVQNEAAPSDAT--ETIAP-----ASAKAAPPPVPVASPPVLV- 1480
              :...:|:||::.:...  :..:.|..|..|:  .|:.|     ||..|...|   :|||..:
Mouse   430 --INDLSPRSSLNRSLSARLRRRERERPPCSASMVGTLPPLEGTSASTSAYFYP---SSPPFHLS 489

  Fly  1481 ----PEPDPTEHLTP-------------------------------------HLVDTSEVAGRIL 1504
                ||..|:|.:.|                                     |::.||.
Mouse   490 VNNYPEKSPSESMEPLDSDYFEDKMNKDTETENSSAVDSENFGETNDILNMTHMMTTSS------ 548

  Fly  1505 QISSGLFHFCLISSSCTLYTWGKNLEHQLGTEDKDRRAVLKPSPIDSIE-------------RPM 1556
              :..|..|..|.......|:.|.:|....||::|.....:.|.|..:.             ||.
Mouse   549 --NEKLLDFSPIQKQQNQDTFEKVMESTPCTENEDSYEYEEMSKIKEVTVYKQYLAKGIYMIRPA 611

  Fly  1557 YV-DCGSDFTLVMTTDHV--VRAF---GGNSNGQCGRDLGPS-VERMRQRVVCLPATKRLVRFES 1614
            .: :..||..:....|.|  .|.|   .|..:.|.|::.... |...:..|:.:...|::...|.
Mouse   612 EILEAFSDEEVGNGLDQVEEPRVFTDGKGLQSKQVGKESDEEIVSEKKTEVMEVADVKKIRESEE 676

  Fly  1615 QCVEVPVEINLPRPRIRLDQDPVRYLKVMPPYQPHFLQPANISFDQHCSVGTPNYKSSTEHAATG 1679
            ......:..:||...:..:.:..:                :|:.::..|.....:.|.||..
Mouse   677 NSKSDSLFDDLPDKTMNSESEDNK----------------DIAEERRSSEQNMTFDSETELV--- 722

  Fly  1680 QDSDDMLSSLENLSQNDASFSYNAPVLGDAHSSLDMDYTPEEQSYVPLPEQAVGSGMPANAEQLL 1744
             :..|.....|..|:.|::.....|.|        ::|:.||:                  ::..
Mouse   723 -EEPDSYMECERHSEQDSAEELEQPKL--------VEYSSEEK------------------DEKD 760

  Fly  1745 GRDDDDGST----YTQS-TEGMGESSLQHLRHYIHYCLYAFH 1781
            .:|||:..|    |.:: ||...|:..:..|.:..:.|...|
Mouse   761 EKDDDEVETENLWYDRNCTEQETENVFRATRFFPKFDLKHDH 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	133/577 (23%)
		RCC1_2	1175..1200	CDD:290274	11/25 (44%)
		RCC1	1193..1240	CDD:278826	17/53 (32%)
		RCC1	1242..1291	CDD:278826	19/48 (40%)
		RCC1_2	1503..1532	CDD:290274	6/28 (21%)
		RCC1	1522..1568	CDD:278826	12/59 (20%)
		RCC1_2	1558..1584	CDD:290274	7/31 (23%)
Rpgr	NP_001171421.1	RCC1_2	78..104	CDD:290274	5/25 (20%)
		RCC1	93..139	CDD:278826	14/57 (25%)
		RCC1	144..193	CDD:278826	18/55 (33%)
		RCC1_2	180..209	CDD:290274	13/28 (46%)
		RCC1	196..243	CDD:278826	19/48 (40%)
		RCC1	246..296	CDD:278826	7/50 (14%)
		RCC1	301..348	CDD:278826	12/46 (26%)
		RCC1	352..398	CDD:278826	12/61 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833519
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840