Protein Alignment ca and Zzef1

DIOPT Version :10

• Sequence 1: NP_733309.3
• Gene: ca / 43518
• FlyBaseID: FBgn0000247
• Length: 1961
• Species: Drosophila melanogaster
• Sequence 2: XP_006532664.1
• Gene: Zzef1 / 195018
• MGIID: 2444286
• Length: 2953
• Species: Mus musculus
• Alignment Length: 2272
• Identity: 396/2272 - (17%)
• Similarity: 675/2272 - (29%)
• Gaps: 914/2272 - (40%)

  Fly    42 LVSEENEILLRYIS--AASGQEVVKMISWFRNRVIHDV----C-----------FDPAGVWLLVL 89
            |||..:..|||::.  ...|:|.|.:..:   |.:.:.    |           ||..|
Mouse    72 LVSRHHGALLRWLEERLGRGEESVTLEQF---RELLEARGAGCSGEQFEEAFAQFDAEG------ 127

  Fly    90 CFDNTLHIVPALALVDKAHG-------------LSACSL-----------------YST------ 118
              |.|:.....|..:..:.|             |.||||                 :|:
Mouse   128 --DGTVDAENMLEALKNSSGANLQGELSHVIRQLQACSLVPGFIDIFSESKEGLGIHSSMILRFL 190

  Fly   119 --TQVTSYIIPFVGPHECPNSKKCPNHSTGLEESTAEPMDQLAENLEQA---------------- 165
              .:::|.:||:.....|.|  .|...|:.|:||    :|||.:..:::
Mouse   191 HRNRISSMVIPYPMLDHCNN--MCTMRSSVLKES----LDQLVQKEKESPGDLARSPEMDKLKSV 249

  Fly   166 -----------------RLQEGEEEEPLGHD----------------LPEHMLVRNSGTEDAVQP 197
                             |:..||.......|                :..|:.:..:.|:.:..|
Mouse   250 TKCYAYIETSSNPADIYRMTNGETSSYWQSDGSARSHWIRLKMKPDVVLRHLSIAVAATDQSYMP 314

  Fly   198 LPQQQQTI-------------------DTTG------NSQV------------------------ 213
               ||.|:                   :.||      |:.:
Mouse   315 ---QQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDTRIHGL 376

  Fly   214 MAASFMASKTCPYPL---SVVWW------------KTNSG-------------QNRAIIGYSDGS 250
            .|..|...|.....:   |.:|:            :||..             |:...:..|.||
Mouse   377 RAVGFQRVKKSGVSVSDASAIWYWSLLTSLVTASMETNPAFVQTVLHNTQKALQHMPPLSLSPGS 441

  Fly   251 ICF-VGLSPN---------------C--PMIAST----AIENGSVMRLV--ICK-----DKAYDG 286
            ..| ..||||               |  |.:..|    |:..||:.:::  :|.     |..||
Mouse   442 TDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAFALARGSIAKVMSSLCTITDHLDTQYD- 505

  Fly   287 VMLLITSSLKQQYKLLLEQKAIKYVYPGDSSPTTREGAWQIVMSVQDKHQSAATGARQSNSSDPA 351
            ...||:|....:..|||     ||..|             :.:::|     |.....:.:.|.|
Mouse   506 ASSLISSMASVRQNLLL-----KYGKP-------------LQLTLQ-----ACDVKGKEDKSGP- 546

  Fly   352 SDSSQLEEDVFAPPSSDD--VVCSGPGAANSDPSTVSASAEAATADVPPPPAPPSYSEAVARQSG 414
                   |::...|.:.|  :..:|...|::..||.|.||...|.               .|...
Mouse   547 -------ENLLVEPWTRDGFLTETGKTRASTIFSTGSDSAFQVTQ---------------IRIMV 589

  Fly   415 DQGGVRFQQQQLPAGSMDGILPATRARLASLKSLGSKKLQA----------IKMRLSDQRQ---- 465
            .:||:         |:..|::.|..:        .|.|..|          .|.:|.:.||
Mouse   590 RRGGI---------GAQCGLVFAYNS--------PSNKFHAEEHFKRFEKYDKWKLQELRQFVKS 637

  Fly   466 ----KFDEFMPDSTMGSFAI---MDSPSVTPEPLGTTSGSFYNIQNLR-STFL----LSALHSNS 518
                ..|:...|..:|.|.:   .|...|             .:|..| :.||    |.....::
Mouse   638 RIGCSSDDLGEDDPIGWFELEEEWDEADV-------------KLQQCRVAKFLMVKFLCTRQESA 689

  Fly   519 HSLTVHSIDISLKPLFVYKIPKHTQEILISSNILYGIHYVDLHCRSDSDHFTAASL--------- 574
            ..|.|..:.||     .|..|...:   ...:|||.      |||.|:::...|:|
Mouse   690 ERLGVQGLSIS-----GYLRPARAE---AEQSILYA------HCRRDTENIHGATLLLRTLQFIQ 740

  Fly   575 -LDDPLVANTE--------------------------KENRDAD-------IEKVDQSDVSAQKS 605
             |...|:...|                          |:||..:       :.|:.||..|..:.
Mouse   741 QLSHDLMQQKESGLKHKSFLDFAGLDLQIFWKFYSKLKQNRREECICAQTLLLKLLQSCFSVLQG 805

  Fly   606 DSTSATTTATSSLDQSDMPSTAINAVSVISSAMASLHTSDEDRFNNLAQLGLFRFENETVLH--- 667
            |..:|:.....:..:|:    .|.|...:.:.:.::  .|:...|::....|.:....|:|:
Mouse   806 DPQAASEEEKPTAQRSE----GIQAAKELYTHLCNV--VDKPNGNSMPMEILKQEVRNTLLNGAA 864

  Fly   668 -LYQMAQYRNPS--AEPETLTKEEKAKAFEL-----------KDIHTPMDYIQFYETADVSSEFS 718
             .:...|.|...  ...:::|:.|:.::.:|           ||   |...:...|.:|:::..:
Mouse   865 IFFPDRQTRRSQLFTMMKSVTEHERKQSLQLTFHSLCTYFSDKD---PGGLLLLPEKSDLATMNT 926

  Fly   719 LRQMEIMQS-------EFPKINYDPSYVITNKNVYT--------------IQLKKEPFELFLDAA 762
            ...:.:|.:       |...:..:.|:......:::              :|||.      .|||
Mouse   927 SEVLAVMNTLLSVAARECELLMLNRSHGAVGSVLFSLFWSVQGSLLSWCFLQLKS------TDAA 985

  Fly   763 LQNEFNQCRDFCNTFDLSFEQCIEFAGDYLLRRKKITQALLTYNKARV---KPIRTALKLAMYGH 824
            .:             :|:.:...::.|.:|...:.|.::||:....:.   |...:...:|....
Mouse   986 AK-------------ELAMDLIEKYVGQFLASMRVILESLLSQYSGKTIVEKLCNSVFSMAARQL 1037

  Fly   825 TYALMQLSAMALKSTYLLRSRYLGHPLLKGILGD----------ITYRHSEDVRVILPEKHEEED 879
            ...|:....:.:....|||.......|||.:..|          .|::..:.  |:|....:|..
Mouse  1038 VIFLLDFCTLDVSHCTLLREFSTLTELLKKLCSDPEGGLSKLDVETWQQEQP--VVLHTWTKEST 1100

  Fly   880 VNSGVFCSDYHYGVDESISALQMSPSSQFHLANLLLITLAEKAVNDKNYIPLWNFL-VTNS---- 939
            .|....|.:.         ::.:||.     |....:...|:...:|.|    ::| .|:|
Mouse  1101 HNYENNCHEV---------SVFISPG-----ATYFEVEFDERCETEKRY----DYLEFTDSRGGK 1147

  Fly   940 -KYHTNMTSI-----VLCQSG-----LFSSAIILAKIRGVCLDTFNALISVVAQEFGWYNELNVC 993
             :|.|.:.:.     |..:.|     ||.|            |:.|       .|:|:  :..|.
Mouse  1148 TRYDTKVGTYKWPKKVTFKDGPRLQFLFHS------------DSSN-------NEWGY--KFTVT 1191

  Fly   994 LYNLSENIFLETITYLPHVSMDYFAFIQEKLHHIRPCVLQRLSKQLNPFSPALRPIVSHNSDCAM 1058
            .|.            ||.|::.:...:|        .::.||..:|.....||:.:....|:.|:
Mouse  1192 AYG------------LPDVAVSWGLDLQ--------LLVSRLMGRLASQCMALKSVHQLGSNMAV 1236

  Fly  1059 SND------NNP---QLF--EFCKSL-IETYLAVLIHMESQRVKY---DSIVNALSNFRINYEDN 1108
            |..      |:|   .:|  :.|..| :|.......|.:.:.||.   |...:.|.:|..:....
Mouse  1237 SQAKLTSVLNSPLWKPVFRHQICPELELEASWPTHPHKDGKEVKNIPDDPCRHFLLDFAQSEPAQ 1301

  Fly  1109 QF-AIESSRFKPISAGCAYCACVVDGTAYFWGSSGIPSYYSAQKSTEPPEPAHAVKSLDLLSQLN 1172
            .| ...|..||.....|...|...|..|   ||       :..::......|...::.||..:|.
Mouse  1302 NFCGPYSELFKGFIQACRKQAPKTDIVA---GS-------TIDQAVNATFAALVYRTPDLYEKLQ 1356

  Fly  1173 LQVHAIKCGRQHTLILTNNGLYSLGNNNLCQLGIGRHMQMALQPMLVTALDGMNITMLEAGQYHN 1237
            ..|::   |.:..|....:.:|||.                         ||:.|.|||..|...
Mouse  1357 KYVNS---GGKIALTEEFSQVYSLA-------------------------DGIRIWMLEMKQKSL 1393

  Fly  1238 AAVADGKLYMWGWGIYGQLGQGSCENIATPQLVSFFKFKKILQISLGHAHTLVLCGAPNSHMEAN 1302
            .::.:......|.    :..:.:.|::|          |:.:|.||     |:|...|.|.....
Mouse  1394 LSLGNDSEEKRGL----EAAEVNPESLA----------KECIQKSL-----LLLKFLPMSKSSKE 1439

  Fly  1303 HCGNELFVFGSNHFGQLGTGNSDHGDTKTNLPVRLEVGDCSLRLIHTKFFTNLAVDEQDRLFTWG 1367
            :|.                              :||                 .|||.|.|
Mouse  1440 NCD------------------------------KLE-----------------TVDETDHL---- 1453

  Fly  1368 SSPQALRLANQIKRRANAKQKMEENQQRELLSKQLEATLLPAPIPSTSTLVEPTTSYAAVVAGST 1432
                     ..:.||......:||:.|..                     ..||.:       :|
Mouse  1454 ---------QPLDRRQRTSSVVEEHFQGS---------------------ASPTEA-------AT 1481

  Fly  1433 PKSSVSDTKDCQDVQNEAAPSDATETIAPASA--KAAPPPVPVASPP-------------VLVPE 1482
            |  :..|.....::|.:..||.. ..:|..|.  :.:||..|...||             :....
Mouse  1482 P--AAGDRSPALEIQPKLLPSSG-PCVAEVSTAEEPSPPSTPTRRPPFTRGRLRLLSFRSMEETR 1543

  Fly  1483 PDPT-EHLTPHLVDTSEVAGRILQISSGLFHFCLISSSCTLYTWGKNLEHQ-----LGTEDKDRR 1541
            |.|| :...|.|.|..:                        :...::|.|:     |.......:
Mouse  1544 PVPTVKEKYPVLKDVMD------------------------FIKDQSLSHESVVKVLSLRKAQGQ 1584

  Fly  1542 AVLKPSPI-----DSIER-----PMYV-------DCGSDFTLVMTTDHVVRAFGGNSNGQCGRDL 1589
            ::|:...|     :|:.:     |.|:       .|..|||          .:.|:..| ||.||
Mouse  1585 SILEVLRIIQYCTESLGQPHCFHPPYILFLLELLTCQKDFT----------NYFGHLEG-CGADL 1638

  Fly  1590 GPSVERMRQRVVCLPATKRLVRFES----------QCVEVP-----------------VEINLPR 1627
            ...:.....::| |...|.:.||.|          .||:..                 |:|.||.
Mouse  1639 HREIRDTYYQLV-LFLVKAIKRFSSINDRSLLPALSCVQTALLHLLDMGWEPSDLAFFVDIQLPD 1702

  Fly  1628 PRIRLDQDPVRYLKVMPPYQPHFLQPANISFDQHCSVGTPNYKSSTEHAATGQDS-------DDM 1685
            ..:.:.|:                   |||.  |.|| ...:....|.|...|:|       |.|
Mouse  1703 LLMNMSQE-------------------NISV--HDSV-ISQWSEEDELADAKQNSEWMDECQDGM 1745

  Fly  1686 LSS-LENLSQNDASFSYNAPVLGDAHSSLDMDYTPEEQSYVPLPEQAVGSGMPANAEQLLGRDDD 1749
            ..: .|.::|.|                      ||:|..:.:        ..|....||..|
Mouse  1746 FEAWYEKIAQED----------------------PEKQRKMHM--------FIARYCDLLNVD-- 1778

  Fly  1750 DGSTYTQSTEGMGESSLQHLRHYIH-----YCLYAFHGLYNPDKIGECARPHRNEYRIRICM--- 1806
                  .|.:|..|.:..|....:.     .|...|.|...|:..|:.......|:....|.
Mouse  1779 ------ISCDGCDEIAPWHRYRCLQCSDMDLCKTCFLGGVKPEGHGDDHEMVNMEFTCDHCQGLI 1837

  Fly  1807 ----LNFRFVEAFRLCLQSCGSAQRTLKLFEYFSKDTGYVP-----------LRRTDLKHLI 1853
                :|....:.|.|| ..|    .|.|.:.|     |::|           :|.:|.:.||
Mouse  1838 IGRRMNCNVCDDFDLC-YGC----YTAKKYSY-----GHLPTHSITAHPMVTIRISDRQRLI 1889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ca	NP_733309.3	ATS1	1181..1587	CDD:444065	72/443 (16%)
Zzef1	XP_006532664.1	FRQ1	<95..141	CDD:444056	9/56 (16%)
		APC10-ZZEF1	250..380	CDD:176488	14/132 (11%)
		CUB	<1119..1189	CDD:412131	17/94 (18%)
		ZZ_EF	1779..1826	CDD:239083	9/46 (20%)
		ZZ	1828..1875	CDD:239069	11/56 (20%)